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Title:
LACTAM COMPOUND DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/084627
Kind Code:
A1
Abstract:
The present invention relates to a lactam compound derivative, a medicine composition comprising the lactam compound derivative, and uses of the composition and the lactam compound derivative in preparation of a medicine for preventing or treating schizophrenia, the lactam compound derivative having a structure as shown in Formula I.

Inventors:
CHEN YIN (CN)
DOU FEI (CN)
QIU YINLI (CN)
YU MINQUAN (CN)
ZHANG GUISEN (CN)
Application Number:
PCT/CN2016/106591
Publication Date:
May 26, 2017
Filing Date:
November 21, 2016
Export Citation:
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Assignee:
NHWA PHARMA CORP (CN)
International Classes:
C07D413/14; A61K31/4725; A61K31/496; A61K31/506; A61K31/517; C07D217/24; C07D239/88; C07D239/90; C07D401/12; C07D405/12; C07D417/12
Domestic Patent References:
WO2012003418A22012-01-05
WO2006112464A12006-10-26
WO2007026959A22007-03-08
Other References:
"Handbook of Chemistry and Physics", 1994
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITH; JERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
S.M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
"Remington' s Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
STAHL; WERMUTH: "Handbook of Pharmaceutical Salts:Properties, Selection, and Use", 2002, WILEY-VCH
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", vol. 14, A.C.S. SYMPOSIUM SERIES
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP002579584
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", J. MED. CHEM., vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: doi:10.1021/jm701260b
See also references of EP 3381915A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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