Title:
β-LACTAM COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2012/157504
Kind Code:
A1
Abstract:
Provided are: a β-lactam compound in which two adjacent carbon atoms present in a β-lactam ring are asymmetric carbon atoms respectively having four different substituents; a method for producing the β-lactam compound; a production intermediate of the β-lactam compound; and a method for producing the production intermediate. A β-lactam compound which is represented by formula (wherein R1 represents a chain alkyl group, a cyclic alkyl chain, an aryl group or an aralkyl group; R2 represents an alkyl group, an aryl group or an aralkyl group; R3 represents an alkyl group, an aryl group, an aralkyl group, an allyl group, a methoxymethyl group or a p-methoxybenzyl group; R4 represents an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an aralkyl group or a halogen atom; and each of E1 and E2 represents a hydrogen atom, an alkoxycarbonyl group, a nitro group or a nitrile group); a method for producing the β-lactam compound; a production intermediate of the β-lactam compound; and a method for producing the production intermediate.
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Inventors:
KAWABATA TAKEO (JP)
YOSHIMURA TOMOYUKI (JP)
YOSHIMURA TOMOYUKI (JP)
Application Number:
PCT/JP2012/061955
Publication Date:
November 22, 2012
Filing Date:
May 10, 2012
Export Citation:
Assignee:
UNIV KYOTO (JP)
KAWABATA TAKEO (JP)
YOSHIMURA TOMOYUKI (JP)
KAWABATA TAKEO (JP)
YOSHIMURA TOMOYUKI (JP)
International Classes:
C07D205/08; C07C231/02; C07C235/28
Other References:
PAN YAN ET AL.: "Fusei Kioku-gata Kyoeki Fuka Hanno o Keiyu suru Tachikan beta-Lactam no Fusei Gosei", DAI 29 KAI ABSTRACTS OF SYMPOSIUM ON MEDICINAL CHEMISTRY, 8 October 2010 (2010-10-08), pages 78 - 79
ASYMMETRIC SYNTHESIS OF MULTISUBSTITUTED BETA-LACTAMS FROM ALPHA-AMINO ACIDS ET AL., ICR ANNUAL REPORT 2009, 2009, pages 9
CLAUDIO PALOMO ET AL.: "The cycloaddition of monoalkylketenes to 2-oxoalkanoic ester-derived imines: a concise stereoselective approach to alpha, beta-disubstituted asparates and 3,4- dialkylsubstituted beta-lactams.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 3, 1993, pages 2461 - 2466
PAULA PEREZ-FAGINAS ET AL.: "Exceptional Stereoselectivity in the Synthesis of 1,3,4- Trisubstituted 4-Carboxy beta-Lactam Derivatives from Amino Acids", ORGANIC LETTERS, vol. 9, 2007, pages 1593 - 1596
PAN YAN ET AL.: "Renzoku suru Yonchikan Fusei Tanso o Motsu beta-Lactam no Fusei Kioku-gata Gosei", DAI 41 KAI CONGRESS OF HETEROCYCLIC CHEMISTRY YOSHISHU, 30 September 2011 (2011-09-30), pages 225 - 226
ASYMMETRIC SYNTHESIS OF MULTISUBSTITUTED BETA-LACTAMS FROM ALPHA-AMINO ACIDS ET AL., ICR ANNUAL REPORT 2009, 2009, pages 9
CLAUDIO PALOMO ET AL.: "The cycloaddition of monoalkylketenes to 2-oxoalkanoic ester-derived imines: a concise stereoselective approach to alpha, beta-disubstituted asparates and 3,4- dialkylsubstituted beta-lactams.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 3, 1993, pages 2461 - 2466
PAULA PEREZ-FAGINAS ET AL.: "Exceptional Stereoselectivity in the Synthesis of 1,3,4- Trisubstituted 4-Carboxy beta-Lactam Derivatives from Amino Acids", ORGANIC LETTERS, vol. 9, 2007, pages 1593 - 1596
PAN YAN ET AL.: "Renzoku suru Yonchikan Fusei Tanso o Motsu beta-Lactam no Fusei Kioku-gata Gosei", DAI 41 KAI CONGRESS OF HETEROCYCLIC CHEMISTRY YOSHISHU, 30 September 2011 (2011-09-30), pages 225 - 226
Attorney, Agent or Firm:
SunCrest Patent and Trademark Attorneys (JP)
Patent business corporation Sun Crest international patent firm (JP)
Patent business corporation Sun Crest international patent firm (JP)
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