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Title:
LACTASE PREPARATION
Document Type and Number:
WIPO Patent Application WO/2011/037058
Kind Code:
A1
Abstract:
Disclosed is a lactase preparation which does not undergo the deactivation of lactase even when the preparation is ingested prior to the ingestion of a lactose-containing food or beverage such as a milk product and therefore can decompose lactose stably and which can prevent the symptoms of lactose tolerance. Specifically disclosed is a lactase preparation comprising lactase and at least one component selected from trisodium citrate, potassium sodium tartrate, calcium carbonate, sodium carbonate and calcium hydrogen phosphate which acts as an antacid. The lactase preparation is characterized by being intended to be ingested prior to the ingestion of a lactose-containing food or beverage to decompose lactose. In the lactose preparation, the antacid is contained at such a content per unit dosage form that the pH value in the stomach can be increased to 4 or higher after the ingestion of the preparation.

Inventors:
GOTO MASATAKA (JP)
HIROSE YOSHIHIKO (JP)
Application Number:
PCT/JP2010/066015
Publication Date:
March 31, 2011
Filing Date:
September 16, 2010
Export Citation:
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Assignee:
AMANO ENZYME INC (JP)
GOTO MASATAKA (JP)
HIROSE YOSHIHIKO (JP)
International Classes:
A61K38/46; A23L1/30; A61K31/194; A61K33/00; A61K33/10; A61K33/42; A61P1/04; A61P1/12; A61P1/14
Domestic Patent References:
WO2007139553A12007-12-06
Foreign References:
JP2002187854A2002-07-05
JP2001506136A2001-05-15
JPS49116291A1974-11-06
JP2003128574A2003-05-08
JP2007510733A2007-04-26
Other References:
WANG, H. ET AL.: "An Acidophilic Beta-Galactosidase from Bispora sp. MEY-1 with High Lactose Hydrolytic Activity under Simulated Gastric Conditions", J AGRIC FOOD CHEM, vol. 57, no. 12, June 2009 (2009-06-01), pages 5535 - 5541, XP008161357
GAO, K.P. ET AL.: "EFFECT OF LACTOSE PREPARATIONS IN ASYMETOMATIC INDIVIDUALS WITH LACTOSE DEFFICIENCY - GASTRIC DIGESTION OF LACTOSE AND BREATH HYDROGEN ANALYSIS", NAGOYA J MED SCI, vol. 65, 2002, pages 21 - 28, XP008161359
K. P. GAO; T. MITSUI; K. FUJIKI; H. ISHIGURO; T. KONDO; NAGOYA J, MED SCI, vol. 65, May 2002 (2002-05-01), pages 21
"FOOD CHEMICALS CODEX", 1 July 1996, NATIONAL ACADEMY PRESS, article "COMMITTEE ON FOOD CHEMICALS CODEX, Food and Nutrition Board Institute of Medicine National Academy of Sciences"
YAMAGATA ET AL., KISO TO RINSHO, vol. 24, no. 10, 1990, pages 1023 - 1028
See also references of EP 2481417A4
Attorney, Agent or Firm:
NISHIO AKIRA (JP)
Nishio Chapter (JP)
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