Title:
LACTIC-ACID-BACTERIA-CONTAINING COMPOSITION, ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION AND/OR HPV-ASSOCIATED TUMORS, AND MUCOSAL IMMUNITY-INDUCING AGENT
Document Type and Number:
WIPO Patent Application WO/2016/121865
Kind Code:
A1
Abstract:
Provided are: a lactic-acid-bacteria-containing composition having, on the cell surfaces thereof, a polypeptide derived from the E7 protein of human papilloma virus (HPV), wherein the amount of polypeptide derived from the E7 protein of HPV contained in the lactic-acid-bacteria-containing composition is 0.03 μg-1.0 μg per 1 × 108 lactic acid bacteria cells; and an oral pharmaceutical composition for treating HPV infection and/or HPV-associated tumors, as well as a mucosal immunity-inducing agent, that include this lactic-acid-bacteria-containing composition.
Inventors:
KAWANA KEI (JP)
IGIMI SHIZUNOBU (JP)
IGIMI SHIZUNOBU (JP)
Application Number:
PCT/JP2016/052481
Publication Date:
August 04, 2016
Filing Date:
January 28, 2016
Export Citation:
Assignee:
UNIV TOKYO (JP)
JAPAN HEALTH SCIENCE FOUND (JP)
JAPAN HEALTH SCIENCE FOUND (JP)
International Classes:
A61K39/12; A61P15/00; A61P31/20; A61P35/00; C07K14/025; C12N1/20; C12N15/09; C12R1/245
Domestic Patent References:
WO2013191225A1 | 2013-12-27 |
Other References:
POO, HARYOUNG ET AL.: "Oral administration of human papillomavirus type 16 E7 displayed on Lactobacillus casei induces E7-specific antitumor effects in C57/BL6 mice", INT. J. CANCER, vol. 119, no. 7, 2006, pages 1702 - 1709, XP055313052
TOMOMITSU SEWAKI: "Generation of Mucosal Vaccine Utilizing Lactobacillus Display System", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 129, no. 11, 2009, pages 1327 - 1332, XP055292103
KEI KAWANA ET AL.: "Tokushu Gan Men'eki Ryoho no Saizensen 11.HPV Bunshi o Hyoteki to shita Nenmaku Men'eki o Kaishita Gan Men'eki Ryoho no Kaihatsu", OBSTETRICS & GYNECOLOGY, vol. 81, no. 2, 2014, pages 210 - 216, XP009505068
RIBELLES, PEDRO ET AL.: "Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface", APPL. MICROBIOL. BIOTECHNOL., vol. 97, no. 3, 2013, pages 1231 - 1239, XP055470343
BERMUDEZ-HUMARAN, LG. ET AL.: "An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci", J. MED. MICROBIOL., vol. 53, no. Pt 5, 2004, pages 427 - 433, XP055470349
BOSMA, TJIBBE ET AL.: "Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria", APPL. ENVIRON. MICROBIOL., vol. 72, no. 1, 2006, pages 880 - 889, XP002569980
SIMSEK, OEMER ET AL.: "Immobilization of nisin producer Lactococcus lactis strains to chitin with surface-displayed chitin-binding domain", APPL. MICROBIOL. BIOTECHNOL., vol. 97, no. 10, 2013, pages 4577 - 4587, XP035328926
RAHA, A.R. ET AL.: "Cell surface display system for Lactococcus lactis: a novel development for oral vaccine", APPL. MICROBIOL. BIOTECHNOL., vol. 68, no. 1, 2005, pages 75 - 81, XP002374776
KAWANA, KEI ET AL.: "Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients", VACCINE, vol. 32, no. 47, 2014, pages 6233 - 6239, XP029076622
STEEN, ANTON ET AL.: "Cell Wall Attachment of a Widely Distributed Peptidoglycan Binding Domain Is Hindered by Cell Wall Constituents", J. BIOL. CHEM., vol. 278, no. 26, 2003, pages 23874 - 23881, XP002410829
See also references of EP 3254693A4
TOMOMITSU SEWAKI: "Generation of Mucosal Vaccine Utilizing Lactobacillus Display System", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 129, no. 11, 2009, pages 1327 - 1332, XP055292103
KEI KAWANA ET AL.: "Tokushu Gan Men'eki Ryoho no Saizensen 11.HPV Bunshi o Hyoteki to shita Nenmaku Men'eki o Kaishita Gan Men'eki Ryoho no Kaihatsu", OBSTETRICS & GYNECOLOGY, vol. 81, no. 2, 2014, pages 210 - 216, XP009505068
RIBELLES, PEDRO ET AL.: "Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface", APPL. MICROBIOL. BIOTECHNOL., vol. 97, no. 3, 2013, pages 1231 - 1239, XP055470343
BERMUDEZ-HUMARAN, LG. ET AL.: "An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci", J. MED. MICROBIOL., vol. 53, no. Pt 5, 2004, pages 427 - 433, XP055470349
BOSMA, TJIBBE ET AL.: "Novel Surface Display System for Proteins on Non-Genetically Modified Gram-Positive Bacteria", APPL. ENVIRON. MICROBIOL., vol. 72, no. 1, 2006, pages 880 - 889, XP002569980
SIMSEK, OEMER ET AL.: "Immobilization of nisin producer Lactococcus lactis strains to chitin with surface-displayed chitin-binding domain", APPL. MICROBIOL. BIOTECHNOL., vol. 97, no. 10, 2013, pages 4577 - 4587, XP035328926
RAHA, A.R. ET AL.: "Cell surface display system for Lactococcus lactis: a novel development for oral vaccine", APPL. MICROBIOL. BIOTECHNOL., vol. 68, no. 1, 2005, pages 75 - 81, XP002374776
KAWANA, KEI ET AL.: "Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients", VACCINE, vol. 32, no. 47, 2014, pages 6233 - 6239, XP029076622
STEEN, ANTON ET AL.: "Cell Wall Attachment of a Widely Distributed Peptidoglycan Binding Domain Is Hindered by Cell Wall Constituents", J. BIOL. CHEM., vol. 278, no. 26, 2003, pages 23874 - 23881, XP002410829
See also references of EP 3254693A4
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
Koichi Hirota (JP)
Koichi Hirota (JP)
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