Title:
LACTOBACILLUS GASSERI KBL697 STRAIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/226003
Kind Code:
A1
Abstract:
The present invention relates to a Lactobacillus gasseri KBL697 strain and a use thereof. The Lactobacillus gasseri KBL697 (accession number KCTC 13520BP) strain according to the present invention attenuates allergic responses of cells, significantly improves symptoms of atopic dermatitis, and exhibits anti-inflammatory and anti-fungal effects and a therapeutic effect for bowel disease such as irritable bowel disease and enteritis. Thus, the single strain alone can achieve all the purposes of alleviating allergy disease and inflammatory disease and improving bowel health, thereby finding advantageous applications as a probiotic substance. In addition, based on the antifungal activity thereof, the strain can be advantageously utilized in a skin topical agent against various skin diseases caused by fungi and in a cosmetic composition and a functional patch for alleviating sensitive skin.
Inventors:
KO WOO RI (KR)
LEE JUNE CHUL (KR)
PARK HYO IN (KR)
NAM TAE WOOK (KR)
KO GWANG PYO (KR)
KIM WOON KI (KR)
HAN DAE HEE (KR)
KIM IN SU (KR)
LEE JIN WOO (KR)
KIM HYE JIN (KR)
LEE JUNE CHUL (KR)
PARK HYO IN (KR)
NAM TAE WOOK (KR)
KO GWANG PYO (KR)
KIM WOON KI (KR)
HAN DAE HEE (KR)
KIM IN SU (KR)
LEE JIN WOO (KR)
KIM HYE JIN (KR)
Application Number:
PCT/KR2019/006232
Publication Date:
November 28, 2019
Filing Date:
May 23, 2019
Export Citation:
Assignee:
KO BIOLABS INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12N1/20; A23L33/135; A61K8/99; A61K35/747; A61P1/00; A61P17/00; A61P29/00; A61P37/08; A61Q19/00; C12R1/225
Domestic Patent References:
| WO1996029083A1 | 1996-09-26 |
Foreign References:
| KR20170049216A | 2017-05-10 | |||
| KR20170054460A | 2017-05-17 | |||
| KR20140040731A | 2014-04-03 | |||
| US9314041B2 | 2016-04-19 | |||
| KR20130115943A | 2013-10-22 | |||
| EP0554418A1 | 1993-08-11 | |||
| EP0415941A1 | 1991-03-13 | |||
| US7195906B2 | 2007-03-27 |
Other References:
DATABASE NUCLEOTIDE 30 May 2017 (2017-05-30), ANONYMOUS: "Lactobacillus gasseri strain 4M13, complete genome", XP055658311, retrieved from NCBI Database accession no. CP021427
KIM K ET AL., EUR J PHARMACOL, vol. 581, 2008, pages 191 - 203
SLYTER, L. L., J. ANIMAL SCI., vol. 43, 1976, pages 910 - 926
JOHNSON, D. E ET AL., J. ANIM. SCI., vol. 56, 1983, pages 735 - 739
L. LACHMAN ET AL.: "The Theory and Practice of Industrial Pharmacy", 1986, pages: 365 - 373
H. SUCKER ET AL.: "Pharmazeutische Technologie", 1991, THIEME, pages: 355 - 359
"Hagers Handbuchder pharmazeutischen Praxis", vol. 7, 1971, SPRINGERVERLAG, pages: 739 - 742,766-778
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., CO., pages: 1689 - 1691
MATSUMOTO M, J. IMMUNOL., 1999
J. LANDY, WORLD J. GASTROENTEROL., 2016
HASEGAWA, S ET AL., CLIN EXP IMMUNOL, vol. 167, 2012, pages 269 - 27
See also references of EP 3798298A4
KIM K ET AL., EUR J PHARMACOL, vol. 581, 2008, pages 191 - 203
SLYTER, L. L., J. ANIMAL SCI., vol. 43, 1976, pages 910 - 926
JOHNSON, D. E ET AL., J. ANIM. SCI., vol. 56, 1983, pages 735 - 739
L. LACHMAN ET AL.: "The Theory and Practice of Industrial Pharmacy", 1986, pages: 365 - 373
H. SUCKER ET AL.: "Pharmazeutische Technologie", 1991, THIEME, pages: 355 - 359
"Hagers Handbuchder pharmazeutischen Praxis", vol. 7, 1971, SPRINGERVERLAG, pages: 739 - 742,766-778
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., CO., pages: 1689 - 1691
MATSUMOTO M, J. IMMUNOL., 1999
J. LANDY, WORLD J. GASTROENTEROL., 2016
HASEGAWA, S ET AL., CLIN EXP IMMUNOL, vol. 167, 2012, pages 269 - 27
See also references of EP 3798298A4
Attorney, Agent or Firm:
LEE & KO IP (KR)
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