LACTOBACILLUS HAVING ABILITY TO INDUCE IL-12 PRODUCTION, AND METHOD FOR CULTURING SAME

Title:

LACTOBACILLUS HAVING ABILITY TO INDUCE IL-12 PRODUCTION, AND METHOD FOR CULTURING SAME

Document Type and Number:

WIPO Patent Application WO/2014/088183

Kind Code:

A1

Abstract:

The present invention provides a novel technology which is capable of producing a large volume of Lactobacillus bacteria and increasing the activity of the obtained Lactobacillus. The Lactobacillus is prepared by culturing in a culture medium and adding an alkaline chemical while controlling the pH, and sterilizing the Lactobacillus by applying stress in the later stage of the cultivation so as to produce Lactobacillus having the ability to induce IL-12 production. Applying stress is preferably selected from the group consisting of: (a) cultivating without adding an alkaline chemical; (b) cultivating at a temperature range in which propagation is suppressed; (c) cultivating by adding 1 wt% or more of salt; and/or (d) cultivating at pH of 5 or below.

Inventors:

KAN TATSUHIKO (JP)
OHWAKI MAKOTO (JP)

Application Number:

PCT/KR2013/006528

Publication Date:

June 12, 2014

Filing Date:

July 22, 2013

Export Citation:

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Assignee:

BIOGENICS KOREA CO LTD (KR)
BIO LAB LTD (JP)
JAPANESE ASS OF CLINICAL RES ON SUPPLEMENTS (JP)

International Classes:

C12N1/20; C12N1/04

Domestic Patent References:

WO2007138993A1

2007-12-06

Foreign References:

KR20090024175A	2009-03-06
KR20110009560A	2011-01-28
KR20070110115A	2007-11-15
KR20070078107A	2007-07-31
JP2010132579A	2010-06-17
JP4621218B2	2011-01-26
JP2004041099A	2004-02-12

Other References: