Title:
LACTOBACILLUS MIXED WITH XYLOOLIGOSACCHARIDES, CELLOBIOSE AND/OR GENTIOOLIGOSACCHARIDES
Document Type and Number:
WIPO Patent Application WO/2019/102218
Kind Code:
A3
Abstract:
The present invention relates to a Lactobacillus spp. selective prebiotic composition comprising one, or a mixture of two or more, of: xylooligosaccharides, cellobiose and/or gentiooligosaccharides. The present invention also relates to a synbiotic composition comprising a probiotic component comprising one or more strains of Lactobacillus rhamnosus and/or one or more strains of Lactobacillus plantarum and a prebiotic component comprising a growth medium which is specific for the growth of the probiotic component, wherein the prebiotic growth medium comprises one or more, or a mixture of two of more, components selected from: xylooligosaccharides, cellobiose and/or gentiooligosaccharides. The present invention also relates to methods of producing and selecting such compositions.
Inventors:
O'HARA STEPHEN (GB)
KOLIDA SOFIA (GB)
KOLIDA SOFIA (GB)
Application Number:
PCT/GB2018/053402
Publication Date:
August 01, 2019
Filing Date:
November 23, 2018
Export Citation:
Assignee:
OPTIBIOTIX LTD (GB)
International Classes:
A61P1/00; A23L33/135; A61K31/702; A61K35/741; A61K35/747
Foreign References:
| CN107242351A | 2017-10-13 | |||
| US20130330299A1 | 2013-12-12 | |||
| JP2005008616A | 2005-01-13 | |||
| US20040005677A1 | 2004-01-08 |
Other References:
MARIA ANANIEVA ET AL: "Gene expression of enzymes involved in utilization of xylooligosaccharides by Lactobacillusstrains", BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, DIAGNOSIS PRESS, SOFIA, BG, vol. 28, no. 5, 3 September 2014 (2014-09-03), pages 941 - 948, XP009511267, ISSN: 1310-2818, DOI: 10.1080/13102818.2014.948257
YU XIUHUA ET AL: "Prebiotic Potential of Xylooligosaccharides Derived from Corn Cobs and Their In Vitro Antioxidant Activity When Combined with Lactobacillus", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, KOREAN SOCIETY FOR APPLIED MICROBIOLOGY, SEOUL, KR, vol. 25, no. 7, 30 June 2015 (2015-06-30), pages 1084 - 1092, XP009511266, ISSN: 1017-7825, DOI: 10.4014/JMB.1501.01022
CHUNCHAI TITIKORN ET AL: "PREBIOTICS, PROBIOTICS OR SYNBIOTICS THERAPY RESTORES COGNITIVE DECLINE IN OBESE RATS", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'SASSOCIATION, vol. 13, no. 7, 1 July 2017 (2017-07-01), XP085217651, ISSN: 1552-5260, DOI: 10.1016/J.JALZ.2017.06.1892
LI ZHAOPING ET AL: "In vitro study of the prebiotic xylooligosaccharide (XOS) on the growth of Bifidobacterium spp and Lactobacillus spp", INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, CARFAX PUBLISHING LTD, GB, vol. 66, no. 8, 17 November 2015 (2015-11-17), pages 919 - 922, XP009511262, ISSN: 0963-7486, DOI: 10.3109/09637486.2015.1064869
CELEBIOGLU HASAN UFUK ET AL: "Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacteriumLactobacillus acidophilusNCFM", JOURNAL OF PROTEOMICS, ELSEVIER, AMSTERDAM, NL, vol. 163, 19 May 2017 (2017-05-19), pages 102 - 110, XP085062526, ISSN: 1874-3919, DOI: 10.1016/J.JPROT.2017.05.015
UMEKI MIKI ET AL: "Effect of Lactobacillusrhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats", JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, UNIVERSITY OF TOKYO PRESS, TOKYO, JP, vol. 50, no. 5, 30 September 2004 (2004-09-30), pages 330 - 334, XP009511206, ISSN: 0301-4800, [retrieved on 20090428], DOI: 10.3177/JNSV.50.330
HOLT S M ET AL: "Growth of various intestinal bacteria on alternansucrase-derived oligosaccharides", LETTERS IN APPLIED MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 40, no. 5, 1 May 2005 (2005-05-01), pages 385 - 390, XP009513775, ISSN: 0266-8254, [retrieved on 20050322], DOI: 10.1111/J.1472-765X.2005.01681.X
ANAS MAMI ET AL: "Screening of autochthonous Lactobacillus species from Algerian raw goats' milk for the production of bacteriocin-like compounds against Staphylococcus aureus", AFRICAN JOURNAL OF BIOTECHNOLOGY, ACADEMIC JOURNALS, NAIROBI, KENYA, vol. 11, no. 20, 8 March 2012 (2012-03-08), pages 4595 - 4606, XP009513778, ISSN: 1684-5315, Retrieved from the Internet DOI: 10.5897/AJB11.3542
VAN ZANTEN GABRIELLA C ET AL: "The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 7, no. 10, 1 January 2012 (2012-01-01), pages e47212 - 1, XP009513777, ISSN: 1932-6203, [retrieved on 20121017], DOI: 10.1371/JOURNAL.PONE.0047212
YU XIUHUA ET AL: "Prebiotic Potential of Xylooligosaccharides Derived from Corn Cobs and Their In Vitro Antioxidant Activity When Combined with Lactobacillus", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, KOREAN SOCIETY FOR APPLIED MICROBIOLOGY, SEOUL, KR, vol. 25, no. 7, 30 June 2015 (2015-06-30), pages 1084 - 1092, XP009511266, ISSN: 1017-7825, DOI: 10.4014/JMB.1501.01022
CHUNCHAI TITIKORN ET AL: "PREBIOTICS, PROBIOTICS OR SYNBIOTICS THERAPY RESTORES COGNITIVE DECLINE IN OBESE RATS", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'SASSOCIATION, vol. 13, no. 7, 1 July 2017 (2017-07-01), XP085217651, ISSN: 1552-5260, DOI: 10.1016/J.JALZ.2017.06.1892
LI ZHAOPING ET AL: "In vitro study of the prebiotic xylooligosaccharide (XOS) on the growth of Bifidobacterium spp and Lactobacillus spp", INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, CARFAX PUBLISHING LTD, GB, vol. 66, no. 8, 17 November 2015 (2015-11-17), pages 919 - 922, XP009511262, ISSN: 0963-7486, DOI: 10.3109/09637486.2015.1064869
CELEBIOGLU HASAN UFUK ET AL: "Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacteriumLactobacillus acidophilusNCFM", JOURNAL OF PROTEOMICS, ELSEVIER, AMSTERDAM, NL, vol. 163, 19 May 2017 (2017-05-19), pages 102 - 110, XP085062526, ISSN: 1874-3919, DOI: 10.1016/J.JPROT.2017.05.015
UMEKI MIKI ET AL: "Effect of Lactobacillusrhamnosus KY-3 and cellobiose as synbiotics on lipid metabolism in rats", JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, UNIVERSITY OF TOKYO PRESS, TOKYO, JP, vol. 50, no. 5, 30 September 2004 (2004-09-30), pages 330 - 334, XP009511206, ISSN: 0301-4800, [retrieved on 20090428], DOI: 10.3177/JNSV.50.330
HOLT S M ET AL: "Growth of various intestinal bacteria on alternansucrase-derived oligosaccharides", LETTERS IN APPLIED MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 40, no. 5, 1 May 2005 (2005-05-01), pages 385 - 390, XP009513775, ISSN: 0266-8254, [retrieved on 20050322], DOI: 10.1111/J.1472-765X.2005.01681.X
ANAS MAMI ET AL: "Screening of autochthonous Lactobacillus species from Algerian raw goats' milk for the production of bacteriocin-like compounds against Staphylococcus aureus", AFRICAN JOURNAL OF BIOTECHNOLOGY, ACADEMIC JOURNALS, NAIROBI, KENYA, vol. 11, no. 20, 8 March 2012 (2012-03-08), pages 4595 - 4606, XP009513778, ISSN: 1684-5315, Retrieved from the Internet
VAN ZANTEN GABRIELLA C ET AL: "The effect of selected synbiotics on microbial composition and short-chain fatty acid production in a model system of the human colon", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 7, no. 10, 1 January 2012 (2012-01-01), pages e47212 - 1, XP009513777, ISSN: 1932-6203, [retrieved on 20121017], DOI: 10.1371/JOURNAL.PONE.0047212
Attorney, Agent or Firm:
APPLEYARD LEES IP LLP (GB)
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