Title:
LACTOBACILLUS PARACASEI STRAIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/216662
Kind Code:
A1
Abstract:
The present invention pertains to: a novel human-derived probiotic strain that is Lactobacillus paracasei KBL382, Lactobacillus paracasei KBL384, or Lactobacillus paracasei KBL385; and a use of the strain for improving intestinal health and treating or preventing intestinal diseases. The strain according to the present invention has excellent anti-inflammatory and immunomodulatory functions, has a superb strengthening effect on tight junctions of the intestinal tract wall, suppresses enteritis-induced weight loss and colon length reduction, thereby exhibiting a therapeutic effect for enteritis, and significantly alleviates the symptoms of atopic dermatitis. Therefore, the strain can be useful as a probiotic material for enhancing anti-inflammatory effects, strengthening immunity, improving intestinal health functions, and alleviating allergic diseases.
Inventors:
KO GWANG PYO (KR)
KIM WOONKI (KR)
JANG WOU-JIN (KR)
SEO BORAM (KR)
LEE JUNE-CHUL (KR)
NAM TAE-WOOK (KR)
KIM INSU (KR)
LEE JIN- WOO (KR)
KIM WOONKI (KR)
JANG WOU-JIN (KR)
SEO BORAM (KR)
LEE JUNE-CHUL (KR)
NAM TAE-WOOK (KR)
KIM INSU (KR)
LEE JIN- WOO (KR)
Application Number:
PCT/KR2019/005553
Publication Date:
November 14, 2019
Filing Date:
May 09, 2019
Export Citation:
Assignee:
KO BIOLABS INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12N1/20; A23L33/135; A61K35/747; A61P1/00; A61P29/00; A61P37/08; C12R1/225
Domestic Patent References:
| WO1996029083A1 | 1996-09-26 |
Foreign References:
| KR101810138B1 | 2017-12-19 | |||
| KR101614262B1 | 2016-04-20 | |||
| KR100419132B1 | 2004-02-18 | |||
| KR100786364B1 | 2007-12-14 | |||
| EP0554418A1 | 1993-08-11 | |||
| EP0415941A1 | 1991-03-13 | |||
| US7195906B2 | 2007-03-27 |
Other References:
DATABASE NUCLEOTIDE 26 November 2017 (2017-11-26), ANONYMOUS: "Lactobacillus paracasei strain NWAFU1561 16S ribosomal RNA gene, partial sequence", XP055651464, retrieved from NCBI Database accession no. MG551239
DATABASE NUCLEOTIDE 9 August 2014 (2014-08-09), ANONYMOUS: "Lactobacillus paracasei subsp. tolerans strain FX-6 16S ribosomal RNA gene, partial sequence", XP055651470, retrieved from NCBI Database accession no. KF544958
DATABASE NUCLEOTIDE 26 April 2016 (2016-04-26), ANONYMOUS: "Lactobacillus paracasei strain PN3 16S ribosomal RNA gene, partial sequence", XP055651479, retrieved from NCBI Database accession no. KU315074
KIM, W. -K. ET AL.: "Administration of Lactobacillus paracasei strains improves immunomodulalion and changes the composition of gut microbiota leading to improvement of colitis in mice", JOURNAL OF FUNCTIONAL FOODS, vol. 52, 30 November 2018 (2018-11-30) - 2019, pages 565 - 575, XP055651487
KIM K ET AL., EUR J PHARMACOL, vol. 581, 2008, pages 191 - 203
REPORT OF A JOINT FAO/WHO WORKING GROUP ON DRAFTING GUIDELINES FOR THE EVALUATION OF PROBIOTICS IN FOOD, LONDON ONTARIO, CANADA, 2002
SLYTER, L. L., J. ANIMAL SCI., vol. 43, 1976, pages 910 - 926
JOHNSON, D. E ET AL., J. ANIM. SCI., vol. 56, 1983, pages 735 - 739
L. LACHMAN ET AL.: "The Theory and Practice of Industrial Pharmacy", 1986, pages: 365 - 373
H. SUCKER ET AL., PHARMAZEUTISCHE TECHNOLOGIE, THIEME, 1991, pages 355 - 359
"Hagers Handbuchder pharmazeutischen Praxis", vol. 7, 1971, SPRINGERVERLAG, pages: 739 - 742,766-778
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., CO.
MATSUMOTO M, J. IMMUNOL., 1999
DATABASE NUCLEOTIDE 9 August 2014 (2014-08-09), ANONYMOUS: "Lactobacillus paracasei subsp. tolerans strain FX-6 16S ribosomal RNA gene, partial sequence", XP055651470, retrieved from NCBI Database accession no. KF544958
DATABASE NUCLEOTIDE 26 April 2016 (2016-04-26), ANONYMOUS: "Lactobacillus paracasei strain PN3 16S ribosomal RNA gene, partial sequence", XP055651479, retrieved from NCBI Database accession no. KU315074
KIM, W. -K. ET AL.: "Administration of Lactobacillus paracasei strains improves immunomodulalion and changes the composition of gut microbiota leading to improvement of colitis in mice", JOURNAL OF FUNCTIONAL FOODS, vol. 52, 30 November 2018 (2018-11-30) - 2019, pages 565 - 575, XP055651487
KIM K ET AL., EUR J PHARMACOL, vol. 581, 2008, pages 191 - 203
REPORT OF A JOINT FAO/WHO WORKING GROUP ON DRAFTING GUIDELINES FOR THE EVALUATION OF PROBIOTICS IN FOOD, LONDON ONTARIO, CANADA, 2002
SLYTER, L. L., J. ANIMAL SCI., vol. 43, 1976, pages 910 - 926
JOHNSON, D. E ET AL., J. ANIM. SCI., vol. 56, 1983, pages 735 - 739
L. LACHMAN ET AL.: "The Theory and Practice of Industrial Pharmacy", 1986, pages: 365 - 373
H. SUCKER ET AL., PHARMAZEUTISCHE TECHNOLOGIE, THIEME, 1991, pages 355 - 359
"Hagers Handbuchder pharmazeutischen Praxis", vol. 7, 1971, SPRINGERVERLAG, pages: 739 - 742,766-778
"Remington's Pharmaceutical Sciences", 1970, MACK PUBL., CO.
MATSUMOTO M, J. IMMUNOL., 1999
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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