Title:
LACTOBACILLUS REUTERI JH53 STRAIN HAVING EXCELLENT ORGANIC ACID RESISTANCE AND CONVERSION OF 1,3-PROPANDIOL FROM GLYCEROL, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/225257
Kind Code:
A1
Abstract:
The present invention relates to a Lactobacillus reuteri JH53 strain having excellent organic acid resistance and conversion of 1,3-propandiol from glycerol, and a use thereof. Since the strain of the present invention has better organic acid resistance and conversion of 1,3-propandiol from glycerol than a parental strain, when the strain of the present invention, which is safe for the human body (GRAS, generally recognized as safe), is used in the process for producing 1,3-propandiol from waste glycerol, unlike conventional GMO strains, the advantages of being safe and eco-friendly and the recycling of resources can be provided, and thus the present invention is very useful in related industries.
Inventors:
KIM CHUL HO (KR)
OH BAEK ROCK (KR)
HEO SUN-YEON (KR)
JU JUNG-HYUN (KR)
OH BAEK ROCK (KR)
HEO SUN-YEON (KR)
JU JUNG-HYUN (KR)
Application Number:
PCT/KR2022/005399
Publication Date:
October 27, 2022
Filing Date:
April 14, 2022
Export Citation:
Assignee:
ACTIVON CO LTD (KR)
International Classes:
C12N1/20; A61K8/99; A61Q17/00; A61Q19/00; C12P7/18; C12R1/225
Foreign References:
| KR20180060605A | 2018-06-07 |
Other References:
JU JUNG-HYUN, WANG DEXIN, HEO SUN-YEON, KIM MIN-SOO, SEO JEONG-WOO, KIM YOUNG-MIN, KIM DAE-HYUK, KANG SOON-AH, KIM CHUL-HO, OH BAE: "Enhancement of 1,3-propanediol production from industrial by-product by Lactobacillus reuteri CH53", MICROBIAL CELL FACTORIES, vol. 19, no. 1, 1 December 2020 (2020-12-01), pages 1 - 10, XP055978213, DOI: 10.1186/s12934-019-1275-x
JYOTSNA JOLLY, BERND HITZMANN, SUBRAMANIAN RAMALINGAM, KADATHUR B. RAMACHANDRAN: "Biosynthesis of 1,3-propanediol from glycerol with Lactobacillus reuteri: Effect of operating variables", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 118, no. 2, 11 February 2014 (2014-02-11), NL , pages 188 - 194, XP055602854, ISSN: 1389-1723, DOI: 10.1016/j.jbiosc.2014.01.003
HEMA VAIDYANATHAN, VIJAYALAKSHMI KANDASAMY, GOPI GOPAL RAMAKRISHNAN, KB RAMACHANDRAN, GUHAN JAYARAMAN, SUBRAMANIAN RAMALINGAM: "Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri", AMB EXPRESS, vol. 1, no. 1, 1 January 2011 (2011-01-01), pages 1 - 8, XP055143214, ISSN: 21910855, DOI: 10.1186/2191-0855-1-37
MARIA ANTONIETTA RICCI, ANNAMARIA RUSSO, ISABELLA PISANO, LUIGI PALMIERI, MARIA DE ANGELIS, GENNARO AGRIMI: "Improved 1,3-Propanediol Synthesis from Glycerol by the Robust Lactobacillus reuteri Strain DSM 20016", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 25, no. 6, 28 June 2015 (2015-06-28), Korea, pages 893 - 902, XP055606921, ISSN: 1017-7825, DOI: 10.4014/jmb.1411.11078
JU JUNG-HYUN; HEO SUN-YEON; CHOI SANG-WHA; KIM YOUNG-MIN; KIM MIN-SOO; KIM CHUL-HO; OH BAEK-ROCK: "Effective bioconversion of 1,3-propanediol from biodiesel-derived crude glycerol using organic acid resistance–enhanced Lactobacillus reuteri JH83", BIORESOURCE TECHNOLOGY, vol. 337, 1 October 2021 (2021-10-01), AMSTERDAM, NL , pages 1 - 8, XP086698792, ISSN: 0960-8524, DOI: 10.1016/j.biortech.2021.125361
JYOTSNA JOLLY, BERND HITZMANN, SUBRAMANIAN RAMALINGAM, KADATHUR B. RAMACHANDRAN: "Biosynthesis of 1,3-propanediol from glycerol with Lactobacillus reuteri: Effect of operating variables", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 118, no. 2, 11 February 2014 (2014-02-11), NL , pages 188 - 194, XP055602854, ISSN: 1389-1723, DOI: 10.1016/j.jbiosc.2014.01.003
HEMA VAIDYANATHAN, VIJAYALAKSHMI KANDASAMY, GOPI GOPAL RAMAKRISHNAN, KB RAMACHANDRAN, GUHAN JAYARAMAN, SUBRAMANIAN RAMALINGAM: "Glycerol conversion to 1, 3-Propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri", AMB EXPRESS, vol. 1, no. 1, 1 January 2011 (2011-01-01), pages 1 - 8, XP055143214, ISSN: 21910855, DOI: 10.1186/2191-0855-1-37
MARIA ANTONIETTA RICCI, ANNAMARIA RUSSO, ISABELLA PISANO, LUIGI PALMIERI, MARIA DE ANGELIS, GENNARO AGRIMI: "Improved 1,3-Propanediol Synthesis from Glycerol by the Robust Lactobacillus reuteri Strain DSM 20016", JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, vol. 25, no. 6, 28 June 2015 (2015-06-28), Korea, pages 893 - 902, XP055606921, ISSN: 1017-7825, DOI: 10.4014/jmb.1411.11078
JU JUNG-HYUN; HEO SUN-YEON; CHOI SANG-WHA; KIM YOUNG-MIN; KIM MIN-SOO; KIM CHUL-HO; OH BAEK-ROCK: "Effective bioconversion of 1,3-propanediol from biodiesel-derived crude glycerol using organic acid resistance–enhanced Lactobacillus reuteri JH83", BIORESOURCE TECHNOLOGY, vol. 337, 1 October 2021 (2021-10-01), AMSTERDAM, NL , pages 1 - 8, XP086698792, ISSN: 0960-8524, DOI: 10.1016/j.biortech.2021.125361
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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