Title:
LACTOBILLUS FOR USE AS PROBIOTIC AND BLOOD CELL POPULATIONS USED FOR EVALUATING IMMUNE RESPONSE TO AGENTS, E.G. PROBIOTICS
Document Type and Number:
WIPO Patent Application WO/2016/083450
Kind Code:
A3
Abstract:
Probiotic formulation comprising Lactobacillus plantarum TIFN 101, deposited under CBS138100, or a bacterial strain comprising a polynucleotide with at least 85% sequence identity to a polynucleotide from L.plantarum and use of the formulation in therapy and the probiotic strain as such. Method for the detection of a response, preferably an immune response, to an agent, comprising: a) stimulating peripheral blood mononuclear cells (PBMC) with at least one antigen; b) identifying a sub-population of PBMC; c) comparing the subpopulations of PBMC with a reference sample which has not been stimulated with at least one antigen of (a). The PBMC subpopulation may be CD3+/CD4+ (Thelper cells).
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Inventors:
DE VOS PAULUS (NL)
TROOST FREDERIK JAN (NL)
MUJAGIC ZLATAN (NL)
FAAS MARIA MARGARETHA (NL)
TROOST FREDERIK JAN (NL)
MUJAGIC ZLATAN (NL)
FAAS MARIA MARGARETHA (NL)
Application Number:
PCT/EP2015/077642
Publication Date:
July 21, 2016
Filing Date:
November 25, 2015
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
International Classes:
A61K35/747; C12N1/20; C12Q1/02; C12Q1/68; G01N33/50; G01N33/569; G01N33/94; C12R1/25
Domestic Patent References:
| WO2009035330A1 | 2009-03-19 | |||
| WO2011092261A1 | 2011-08-04 | |||
| WO2014184644A1 | 2014-11-20 |
Foreign References:
| CN102747012A | 2012-10-24 | |||
| US20140335066A1 | 2014-11-13 | |||
| US20060257384A1 | 2006-11-16 | |||
| FR2848115A1 | 2004-06-11 | |||
| US20150240200A1 | 2015-08-27 |
Other References:
ZHANG ZHUO-YANG ET AL: "Complete genome sequence of Lactobacillus plantarum JDM1", JOURNAL OF BACTERIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 191, no. 15, 1 August 2009 (2009-08-01), pages 5020 - 5021, XP002563276, ISSN: 0021-9193, [retrieved on 20090522], DOI: 10.1128/JB.00587-09
KLEEREBEZEM MICHIEL ET AL: "Complete genome sequence of Lactobacillus plantarum WCFS1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 1990 - 1995, XP002285325, ISSN: 0027-8424, DOI: 10.1073/PNAS.0337704100
KLEEREBEZEM MICHIEL ET AL: "Complete genome sequence of Lactobacillus plantarum WCFS1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 1990 - 1995, XP002285325, ISSN: 0027-8424, DOI: 10.1073/PNAS.0337704100
Attorney, Agent or Firm:
NEDERLANDSCH OCTROOIBUREAU (2502 LS The Hague, NL)
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