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Title:
LAMININ 511 PRODUCTION PROMOTER, BASAL EPIDERMAL LAYER STABILIZER AND/OR SCREENING METHOD FOR AGENT TO MINIMIZE REDUCTION IN OR PROMOTE INCREASE IN EPIDERMAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2018/074606
Kind Code:
A1
Abstract:
The purpose of this invention is to provide a method with which it is easy to perform screening for an agent that proliferates or an agent that minimizes the reduction in MCSP-positive basal epidermal stem cells. Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation, said agent including at least one extract selected from among a group consisting of brown algae, red algae and green algae.

Inventors:
IRIYAMA SHUNSUKE (JP)
TANNO SAORI (JP)
Application Number:
PCT/JP2017/038079
Publication Date:
April 26, 2018
Filing Date:
October 20, 2017
Export Citation:
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Assignee:
SHISEIDO CO LTD (JP)
International Classes:
C12Q1/68; A61K31/4166; A61K36/03; A61K36/04; A61K36/05; A61P17/00; A61P43/00; C12N15/09; G01N33/68
Domestic Patent References:
WO2011040496A12011-04-07
Foreign References:
JP2016030750A2016-03-07
JP2000080024A2000-03-21
JP2012097049A2012-05-24
JP2016169238A2016-09-23
Other References:
IMANISHI, H. ET AL.: "Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis", MED. MOL. MORPHOL., vol. 47, 2014, pages 38 - 42, XP055479738
MUFFLER, S. ET AL.: "A Stable Niche Supports Long-Term Maintenance of Human Epidermal Stem Cells in Organotypic Cultures", STEM CELLS, vol. 26, 2008, pages 2506 - 2515, XP055479739
See also references of EP 3530750A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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