Title:
LASOFOXIFENE MODULATION OF MEMBRANE-INITIATED ESTROGEN SIGNALS AND METHODS FOR TUMOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2018/129645
Kind Code:
A1
Abstract:
The present invention found that lasofoxifene is an antagonist of ER-α36. It not only inhibits the growth of ER-α36 positive lung, colon and gastric cancers, and also it can inhibit the growth of acquired or de novo tamoxifen-resistant MCF-7 cells. Our finding also provides methods and compositions for treating cancer comprising lasofoxifene alone or in combination with at least one other agent selected from the group consisting of gefitinib and/or trastuzumab or functional equivalent thereof, and an inhibitor in hormonal or epidermal growth factor signal transduction pathways.
Inventors:
YANG JUN (CN)
XU WENPING (CN)
XU WENPING (CN)
Application Number:
PCT/CN2017/070712
Publication Date:
July 19, 2018
Filing Date:
January 10, 2017
Export Citation:
Assignee:
WANG WEI (CN)
International Classes:
A61K31/40; A61K31/5377; A61K39/395; A61P35/00
Domestic Patent References:
| WO2009126662A1 | 2009-10-15 | |||
| WO2008145075A2 | 2008-12-04 |
Foreign References:
| CN103562226A | 2014-02-05 | |||
| US20110224149A1 | 2011-09-15 | |||
| CZ2008000058W | 2008-05-28 |
Other References:
STEVEN R. CUMMINGS ET AL.: "Lasofoxifene in Postmenopausal Women with Osteoporosis", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 362, no. 8, 25 February 2010 (2010-02-25), pages 686 - 696, XP055438776, ISSN: 0028-4793
LIANG SHI ET AL.: "Expression of ER-a36, a Novel Variant of Estrogen Receptor a, and Resistance to Tamoxifen Treatment in Breast Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 27, no. 21, 20 July 2009 (2009-07-20), pages 3423 - 3429, XP055248230
XIE XIN-CI ET AL.: "Advances in Research of Estrogen Receptor in Tumor Development", PHARMACEUTICAL BIOTECHNOLOGY, vol. 22, no. 2, 31 December 2015 (2015-12-31), pages 156 - 159, XP009515389, ISSN: 1005-8915
WANG Z.Y. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 103, no. 24, 2006, pages 9063 - 8
SHI ET AL., J. CLIN. ONCOL., vol. 27, no. 31, 2009, pages 3423 - 9
MOCELLIN ET AL., J. NATL. CANCER INST., vol. 108, no. 2, 2016, pages 318
CUMMINGS, S. ET AL., NEJM, vol. 362, 2010, pages 686 - 696
SEGAL, E. ET AL., NAT. GENET., vol. 34, 2003, pages 66 - 176
SEGAL, E. ET AL., NAT. GENET., vol. 36, 2004, pages 1090 - 1098
BARRY, W. T. ET AL., BIOINFORMATICS, vol. 21, 2005, pages 1943 - 1949
TIAN, L. ET AL., PROC NAT'L ACAD SCI USA, vol. 102, 2005, pages 13544 - 13549
NOVAK B AJAIN AN, BIOINFORMATICS, vol. 22, 2006, pages 233 - 41
MAGLIETTA R ET AL., BIOINFORMATICS, vol. 23, 2007, pages 2063 - 72
BUSSEMAKER H J, BMC BIOINFORMATICS, vol. 8, 2007, pages S6
GENNARI L.: "Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis", DRUGS TODAY (BARC, vol. 42, no. 6, June 2006 (2006-06-01), pages 355 - 67, XP002755915, DOI: 10.1358/dot.2006.42.6.973583
BOONYARATANAKORNKIT, V.: "Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor", STEROIDS, vol. 76, no. 9, August 2011 (2011-08-01), pages 877 - 84
KANG LZHANG XXIE YTU YWANG DLIU ZWANG ZY: "Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling", MOL ENDOCRINOL, vol. 24, no. 4, April 2010 (2010-04-01), pages 709 - 21
RAO J ET AL., J STEROID BIOCHEM MOL BIOL, vol. 127, no. 3-5, November 2011 (2011-11-01), pages 231 - 7
BUTLER WBKELSEY WHGORAN N: "Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens", CANCER RES, vol. 41, no. 1, January 1981 (1981-01-01), pages 82 - 8
CESARONE GGAROFALO CABRAMS MTIGOUCHEVA OALEXEEV VYOON KSURMACZ E: "Wickstrom E. RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells", J CELL BIOCHEM, vol. 98, no. 2, 15 May 2006 (2006-05-15), pages 440 - 50
RAMCHANDRAN KPATEL JD: "Sex Differences in Susceptibility to Carcinogens", SEMIN ONCOL, vol. 36, 2009, pages 516 - 523
KIYOHARA C ET AL., GENDER MEDICINE, vol. 7, 2010, pages 381 - 401
BOUCHARDY CBENHAMOU SSCHAFFAR RVERKOOIJEN HMFIORETTA GSCHUBERT HVINH-HUNG VSORIA J-CVLASTOS GRAPID E: "Lung cancer mortality risk among breast cancer patients treated with anti-estrogens", CANCER, vol. 117, 2011, pages 1288 - 1295
REVANKAR CMCIMINO DFSKLAR LAARTERBURN JBPROSSNITZ ER: "A transmembrane intracellular estrogen receptor mediates rapid cell signaling", SCIENCE, vol. 307, no. 5715, 11 March 2005 (2005-03-11), pages 1625 - 30, XP002465103, DOI: 10.1126/science.1106943
WANG ZZHANG XSHEN PLOGGIE BWCHANG YDEUEL TF: "Identification, cloning, and expression of human estrogen receptor-a 36, a novel variant of human estrogen receptor- a 66", BIOCHEM BIOPHYS RES COMMUN, vol. 336, 2005, pages 1023 - 1027, XP027230277, DOI: 10.1016/j.bbrc.2005.08.226
KIYOHARA C, OHNO Y: "Sex differences in lung cancer susceptibility: a review", MEDICINE, vol. 7, 2010, pages 381 - 401, XP027478365, DOI: 10.1016/j.genm.2010.10.002
SIPPONEN PCORREA P: "Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis", GASTRIC CANCER, vol. 5, 2002, pages 213 - 219
FERNANDEZ EGALLUS SBOSETTI C ET AL.: "Hormone replacement therapy and cancer risk: a systematic analysis from a network of case-control studies", INT J CANCER, vol. 105, 2003, pages 408 - 412
FRISE SKREIGER NGALLINGER S ET AL.: "Menstrual and reproductive risk factors and risk for gastric adenocarcinoma in women: findings from the canadian national enhanced cancer surveillance system", ANN EPIDEMIOL, vol. 16, 2006, pages 908 - 916, XP025113610, DOI: 10.1016/j.annepidem.2006.03.001
KANEKO STAMAKOSHI AOHNO Y ET AL.: "Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females", CANCER CAUSES CONTROL, vol. 14, 2003, pages 53 - 59
LINDBLAD MGARCIA RODRIGUEZ LACHANDANOS ELAGERGREN J: "Hormone replacement therapy and risks of oesophagea and gastric adenocarcinomas", BR J CANCER, vol. 94, 2006, pages 136 - 141
LINDBLAD M, YE W, RUBIO C AND LAGERGREN J: "Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden ", CANCER EPIDEMIOL BIOMARKERS PREV, vol. 13, 2004, pages 2203 - 2207
CHANDANOS ELINDBLAD MJIA C ET AL.: "Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden", BR J CANCER, vol. 95, 2006, pages 118 - 122
MATSUYAMA YTOMINAGA TNOMURA Y ET AL.: "Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan", ANN ONCOL, vol. 11, 2000, pages 1537 - 1543
DUELL EJ, TRAVIER N, LUJ AN-BARROSO L: "Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition ", AM J EPIDEMIOL, vol. 172, 2010, pages 1384 - 1393
MAUVAIS-JARVIS FCLEGG DJHEVENER AL: "The role of estrogens in control of energy balance and glucose homeostasis", ENDOCR REV, vol. 34, no. 3, June 2013 (2013-06-01), pages 309 - 38
RAO J, JIANG X, WANG Y, CHEN B: "Advances in the understanding of the structure and function of ER-a36, a novel variant of human estrogen receptor-alpha ", MOL BIOL, vol. 127, no. 3-5, November 2011 (2011-11-01), pages 231 - 7
WANG J, LI J, FANG R, XIE S, WANG L, XU C: "Expression of ER-a36 in gastric cancer samples and in their matched normal tissues ", ONCOL LETT, vol. 3, no. 1, January 2012 (2012-01-01), pages 172 - 175
WHITE CLI CYANG JPETRENKO NBMADESH MTHOMPSON CBFOSKETT JK: "The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R", NAT CELL BIOL, vol. 7, no. 10, October 2005 (2005-10-01), pages 1021 - 8
NILSSON BOOLDE BLEEB-LUNDBERG LM: "G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling", BR J PHARMACOL, vol. 163, no. 6, July 2011 (2011-07-01), pages 1131 - 9
MARTENSSON LTESALEHI SAWINDAHL SGOMEZ MFSWARD KDASZKIEWICZ-NILSSON JWENDT AANDERSSON NHELLSTRAND PGRANDE PO: "Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases bloodpressure, and eliminates estradiol-stimulated insulin release in female mice", ENDOCRINOLOGY, vol. 150, no. 2, February 2009 (2009-02-01), pages 687 - 98, XP008113897, DOI: 10.1210/en.2008-0623
MOCELLIN S, PILATI P, BRIARAVA M, NITTI D: "Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials", J NATL CANCER INST, vol. 108, no. 2, 18 November 2015 (2015-11-18), pages 318
LIN SHILINGYAN WANGBEIBEI WANGSANDA MARIA CRETOIUQUN WANGXIANGDONG WANGCHENGSHUI CHEN: "Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 12, 2014, pages 70, XP021180949, DOI: 10.1186/1479-5876-12-70
NEHRA R, RIGGINS RB, SHAJAHAN AN, ZWART A, CRAWFORD AC, CLARKE R: "BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells ", FASEB J, vol. 24, no. 6, June 2010 (2010-06-01), pages 2040 - 55
KE HZ, PARALKAR VM, GRASSER WA, CRAWFORD DT, QI H, SIMMONS HA, PIRIE CM, CHIDSEY-FRINK KL, OWEN TA, SMOCK SL, CHEN HK, JEE WS, CAM: "Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models ", ENDOCRINOLOGY, vol. 139, no. 4, April 1998 (1998-04-01), pages 2068 - 76, XP000893016, DOI: 10.1210/en.139.4.2068
KELLY MJLEVIN ER: "Rapid actions of plasma membrane estrogen receptors", TRENDS ENDOCRINOL METAB, vol. 12, no. 4, May 2001 (2001-05-01), pages 152 - 6
SHIBATA YVOELTZ GK: "Rapoport TA. Rough sheets and smooth tubules", CELL, vol. 126, no. 3, 11 August 2006 (2006-08-11), pages 435 - 9
VERDEJO HEFERREIRA JIGLEWSKI MCHIONG MSIMMEN TZORZANO AHILL JAROTHERMEL BASZABADKAI GLAVANDERO S: "Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress", J CELL SCI., vol. 124, no. 13, 1 July 2011 (2011-07-01), pages 2143 - 52
PROSSNITZ ERBARTON M: "Estrogen biology: new insights into GPER function and clinical opportunities", MOL CELL ENDOCRINOL, vol. 389, no. 1-2, 25 May 2014 (2014-05-25), pages 71 - 83
See also references of EP 3568132A4
LIANG SHI ET AL.: "Expression of ER-a36, a Novel Variant of Estrogen Receptor a, and Resistance to Tamoxifen Treatment in Breast Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 27, no. 21, 20 July 2009 (2009-07-20), pages 3423 - 3429, XP055248230
XIE XIN-CI ET AL.: "Advances in Research of Estrogen Receptor in Tumor Development", PHARMACEUTICAL BIOTECHNOLOGY, vol. 22, no. 2, 31 December 2015 (2015-12-31), pages 156 - 159, XP009515389, ISSN: 1005-8915
WANG Z.Y. ET AL., PROC. NATL. ACAD. SCI. USA., vol. 103, no. 24, 2006, pages 9063 - 8
SHI ET AL., J. CLIN. ONCOL., vol. 27, no. 31, 2009, pages 3423 - 9
MOCELLIN ET AL., J. NATL. CANCER INST., vol. 108, no. 2, 2016, pages 318
CUMMINGS, S. ET AL., NEJM, vol. 362, 2010, pages 686 - 696
SEGAL, E. ET AL., NAT. GENET., vol. 34, 2003, pages 66 - 176
SEGAL, E. ET AL., NAT. GENET., vol. 36, 2004, pages 1090 - 1098
BARRY, W. T. ET AL., BIOINFORMATICS, vol. 21, 2005, pages 1943 - 1949
TIAN, L. ET AL., PROC NAT'L ACAD SCI USA, vol. 102, 2005, pages 13544 - 13549
NOVAK B AJAIN AN, BIOINFORMATICS, vol. 22, 2006, pages 233 - 41
MAGLIETTA R ET AL., BIOINFORMATICS, vol. 23, 2007, pages 2063 - 72
BUSSEMAKER H J, BMC BIOINFORMATICS, vol. 8, 2007, pages S6
GENNARI L.: "Lasofoxifene: a new type of selective estrogen receptor modulator for the treatment of osteoporosis", DRUGS TODAY (BARC, vol. 42, no. 6, June 2006 (2006-06-01), pages 355 - 67, XP002755915, DOI: 10.1358/dot.2006.42.6.973583
BOONYARATANAKORNKIT, V.: "Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor", STEROIDS, vol. 76, no. 9, August 2011 (2011-08-01), pages 877 - 84
KANG LZHANG XXIE YTU YWANG DLIU ZWANG ZY: "Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling", MOL ENDOCRINOL, vol. 24, no. 4, April 2010 (2010-04-01), pages 709 - 21
RAO J ET AL., J STEROID BIOCHEM MOL BIOL, vol. 127, no. 3-5, November 2011 (2011-11-01), pages 231 - 7
BUTLER WBKELSEY WHGORAN N: "Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens", CANCER RES, vol. 41, no. 1, January 1981 (1981-01-01), pages 82 - 8
CESARONE GGAROFALO CABRAMS MTIGOUCHEVA OALEXEEV VYOON KSURMACZ E: "Wickstrom E. RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells", J CELL BIOCHEM, vol. 98, no. 2, 15 May 2006 (2006-05-15), pages 440 - 50
RAMCHANDRAN KPATEL JD: "Sex Differences in Susceptibility to Carcinogens", SEMIN ONCOL, vol. 36, 2009, pages 516 - 523
KIYOHARA C ET AL., GENDER MEDICINE, vol. 7, 2010, pages 381 - 401
BOUCHARDY CBENHAMOU SSCHAFFAR RVERKOOIJEN HMFIORETTA GSCHUBERT HVINH-HUNG VSORIA J-CVLASTOS GRAPID E: "Lung cancer mortality risk among breast cancer patients treated with anti-estrogens", CANCER, vol. 117, 2011, pages 1288 - 1295
REVANKAR CMCIMINO DFSKLAR LAARTERBURN JBPROSSNITZ ER: "A transmembrane intracellular estrogen receptor mediates rapid cell signaling", SCIENCE, vol. 307, no. 5715, 11 March 2005 (2005-03-11), pages 1625 - 30, XP002465103, DOI: 10.1126/science.1106943
WANG ZZHANG XSHEN PLOGGIE BWCHANG YDEUEL TF: "Identification, cloning, and expression of human estrogen receptor-a 36, a novel variant of human estrogen receptor- a 66", BIOCHEM BIOPHYS RES COMMUN, vol. 336, 2005, pages 1023 - 1027, XP027230277, DOI: 10.1016/j.bbrc.2005.08.226
KIYOHARA C, OHNO Y: "Sex differences in lung cancer susceptibility: a review", MEDICINE, vol. 7, 2010, pages 381 - 401, XP027478365, DOI: 10.1016/j.genm.2010.10.002
SIPPONEN PCORREA P: "Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis", GASTRIC CANCER, vol. 5, 2002, pages 213 - 219
FERNANDEZ EGALLUS SBOSETTI C ET AL.: "Hormone replacement therapy and cancer risk: a systematic analysis from a network of case-control studies", INT J CANCER, vol. 105, 2003, pages 408 - 412
FRISE SKREIGER NGALLINGER S ET AL.: "Menstrual and reproductive risk factors and risk for gastric adenocarcinoma in women: findings from the canadian national enhanced cancer surveillance system", ANN EPIDEMIOL, vol. 16, 2006, pages 908 - 916, XP025113610, DOI: 10.1016/j.annepidem.2006.03.001
KANEKO STAMAKOSHI AOHNO Y ET AL.: "Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females", CANCER CAUSES CONTROL, vol. 14, 2003, pages 53 - 59
LINDBLAD MGARCIA RODRIGUEZ LACHANDANOS ELAGERGREN J: "Hormone replacement therapy and risks of oesophagea and gastric adenocarcinomas", BR J CANCER, vol. 94, 2006, pages 136 - 141
LINDBLAD M, YE W, RUBIO C AND LAGERGREN J: "Estrogen and risk of gastric cancer: a protective effect in a nationwide cohort study of patients with prostate cancer in Sweden ", CANCER EPIDEMIOL BIOMARKERS PREV, vol. 13, 2004, pages 2203 - 2207
CHANDANOS ELINDBLAD MJIA C ET AL.: "Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden", BR J CANCER, vol. 95, 2006, pages 118 - 122
MATSUYAMA YTOMINAGA TNOMURA Y ET AL.: "Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan", ANN ONCOL, vol. 11, 2000, pages 1537 - 1543
DUELL EJ, TRAVIER N, LUJ AN-BARROSO L: "Menstrual and reproductive factors, exogenous hormone use, and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition ", AM J EPIDEMIOL, vol. 172, 2010, pages 1384 - 1393
MAUVAIS-JARVIS FCLEGG DJHEVENER AL: "The role of estrogens in control of energy balance and glucose homeostasis", ENDOCR REV, vol. 34, no. 3, June 2013 (2013-06-01), pages 309 - 38
RAO J, JIANG X, WANG Y, CHEN B: "Advances in the understanding of the structure and function of ER-a36, a novel variant of human estrogen receptor-alpha ", MOL BIOL, vol. 127, no. 3-5, November 2011 (2011-11-01), pages 231 - 7
WANG J, LI J, FANG R, XIE S, WANG L, XU C: "Expression of ER-a36 in gastric cancer samples and in their matched normal tissues ", ONCOL LETT, vol. 3, no. 1, January 2012 (2012-01-01), pages 172 - 175
WHITE CLI CYANG JPETRENKO NBMADESH MTHOMPSON CBFOSKETT JK: "The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R", NAT CELL BIOL, vol. 7, no. 10, October 2005 (2005-10-01), pages 1021 - 8
NILSSON BOOLDE BLEEB-LUNDBERG LM: "G protein-coupled oestrogen receptor 1 (GPER1)/GPR30: a new player in cardiovascular and metabolic oestrogenic signalling", BR J PHARMACOL, vol. 163, no. 6, July 2011 (2011-07-01), pages 1131 - 9
MARTENSSON LTESALEHI SAWINDAHL SGOMEZ MFSWARD KDASZKIEWICZ-NILSSON JWENDT AANDERSSON NHELLSTRAND PGRANDE PO: "Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases bloodpressure, and eliminates estradiol-stimulated insulin release in female mice", ENDOCRINOLOGY, vol. 150, no. 2, February 2009 (2009-02-01), pages 687 - 98, XP008113897, DOI: 10.1210/en.2008-0623
MOCELLIN S, PILATI P, BRIARAVA M, NITTI D: "Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials", J NATL CANCER INST, vol. 108, no. 2, 18 November 2015 (2015-11-18), pages 318
LIN SHILINGYAN WANGBEIBEI WANGSANDA MARIA CRETOIUQUN WANGXIANGDONG WANGCHENGSHUI CHEN: "Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 12, 2014, pages 70, XP021180949, DOI: 10.1186/1479-5876-12-70
NEHRA R, RIGGINS RB, SHAJAHAN AN, ZWART A, CRAWFORD AC, CLARKE R: "BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells ", FASEB J, vol. 24, no. 6, June 2010 (2010-06-01), pages 2040 - 55
KE HZ, PARALKAR VM, GRASSER WA, CRAWFORD DT, QI H, SIMMONS HA, PIRIE CM, CHIDSEY-FRINK KL, OWEN TA, SMOCK SL, CHEN HK, JEE WS, CAM: "Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models ", ENDOCRINOLOGY, vol. 139, no. 4, April 1998 (1998-04-01), pages 2068 - 76, XP000893016, DOI: 10.1210/en.139.4.2068
KELLY MJLEVIN ER: "Rapid actions of plasma membrane estrogen receptors", TRENDS ENDOCRINOL METAB, vol. 12, no. 4, May 2001 (2001-05-01), pages 152 - 6
SHIBATA YVOELTZ GK: "Rapoport TA. Rough sheets and smooth tubules", CELL, vol. 126, no. 3, 11 August 2006 (2006-08-11), pages 435 - 9
VERDEJO HEFERREIRA JIGLEWSKI MCHIONG MSIMMEN TZORZANO AHILL JAROTHERMEL BASZABADKAI GLAVANDERO S: "Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress", J CELL SCI., vol. 124, no. 13, 1 July 2011 (2011-07-01), pages 2143 - 52
PROSSNITZ ERBARTON M: "Estrogen biology: new insights into GPER function and clinical opportunities", MOL CELL ENDOCRINOL, vol. 389, no. 1-2, 25 May 2014 (2014-05-25), pages 71 - 83
See also references of EP 3568132A4
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SHANGHAI HUAGONG PATENT AGENCY (CN)
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