SHIEH PEYTON (US)
BROWN CHRISTOPHER (US)
CLAIMS What is claimed is: 1. A first monomer, wherein the first monomer is of Formula (A1): (A1), or salt thereof, wherein: Z is C(RP)2 or O; each instance of RP is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of is independently a single bond or double bond; each instance of RH is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –ORa, –OCN, –OC(=O)Ra, –OC(=S)Ra, – OC(=O)ORa, –OC(=O)N(Ra)2,–OS(=O)Ra, –OS(=O)ORa, –OS(=O)N(Ra)2, –OS(=O)2Ra, – OS(=O)2ORa, –OS(=O)2N(Ra)2, –OSi(Ra)3, –OSi(Ra)2(ORa), –OSi(Ra)(ORa)2, –OSi(ORa)3, oxo, – N(Ra)2, –N=C(Ra)2, =NRa, –NC, –NCO, –N3, –NO2, –NRaC(=O)Ra, –NRaC(=O)ORa, – NRaC(=O)N(Ra)2, –NRaS(=O)Ra, –NRaS(=O)ORa, –NRaS(=O)N(Ra)2, –NRaS(=O)2Ra, – NRaS(=O)2ORa, –NRaS(=O)2N(Ra)2, –SRa, –SCN, –S(=O)Ra, –S(=O)ORa, –S(=O)N(Ra)2, – S(=O)2Ra, –S(=O)2ORa, –S(=O)2N(Ra)2, –SeRa, –CN, –C(=NRa)Ra, –C(=NRa)ORa, – C(=NRa)N(Ra)2, –C(=O)Ra, –C(=O)ORa, –C(=O)SRa, –C(=S)ORa, –C(=O)N(Ra)2, or a latent- fluoride moiety; or the two instances of RH are joined with the intervening carbon atoms to form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent of the substituted monocyclic carbocyclic ring, substituted monocyclic heterocyclic ring, substituted monocyclic aryl ring, or substituted monocyclic heteroaryl ring is a latent-fluoride moiety; each instance of Ra is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl; and each instance of the latent-fluoride moiety comprises one or more through covalent bonds a, wherein each covalent bond a is cleavable in the presence of a degradation composition comprising one or more nucleophiles, one or more bases, or a combination thereof; provided that the first monomer comprises at least one instance of the latent-fluoride moiety. 2. A second monomer, wherein the second monomer is of Formula (B1): or a salt thereof, wherein: Y is O or C(RQ)2; each instance of RQ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RY is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RZ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; RK1 is hydrogen, halogen, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, –LK1–(substituted or unsubstituted carbocyclyl), –LK1–(substituted or unsubstituted heterocyclyl), –LK1–(substituted or unsubstituted aryl), –LK1–(substituted or unsubstituted heteroaryl), –ORN1, a latent-fluoride moiety, or –LK1–(a latent-fluoride moiety); LK1 is a single bond, –O–, substituted or unsubstituted, C1-10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; RN1 is hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; RK2 is hydrogen, halogen, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, –LK2–(substituted or unsubstituted carbocyclyl), –LK2–(substituted or unsubstituted heterocyclyl), –LK2–(substituted or unsubstituted aryl), –LK2–(substituted or unsubstituted heteroaryl), –ORN2, a latent-fluoride moiety, or –LK2–(a latent-fluoride moiety); LK2 is a single bond, –O–, substituted or unsubstituted, C1-10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; RN2 is hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; or RK1 and RK2 are joined with the intervening atom to form substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, optionally wherein at least one substituent of the substituted carbocyclyl or substituted heterocyclyl is a latent-fluoride moiety; j is 1, 2, or 3; k is 0, 1, 2, or 3; and each instance of the latent-fluoride moiety comprises one or more through covalent bonds a, wherein each covalent bond a is cleavable in the presence of a degradation composition comprising one or more nucleophiles, one or more bases, or a combination thereof; provided that the second monomer comprises at least one instance of the latent-fluoride moiety. 3. A copolymer prepared by a method comprising polymerizing: one or more instances of a first monomer, wherein each instance of the first monomer independently comprises at least one C=C and/or at least one C≡C and optionally comprises one or more instances of a latent-fluoride moiety; one or more instances of a second monomer, wherein each instance of the second monomer is of Formula (B): (B), or a salt thereof; and optionally one or more instances of a third monomer; in the presence of a metathesis catalyst; wherein: each instance of Y is independently O or C(RQ)2; each instance of RQ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RY is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RZ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RK1 is independently hydrogen, halogen, substituted or unsubstituted, C1- 10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, – LK1–(substituted or unsubstituted carbocyclyl), –LK1–(substituted or unsubstituted heterocyclyl), –LK1–(substituted or unsubstituted aryl), –LK1–(substituted or unsubstituted heteroaryl), –ORN1, a latent-fluoride moiety, or –LK1–(a latent-fluoride moiety); each instance of LK1 is independently a single bond, –O–, substituted or unsubstituted, C1- 10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; each instance of RN1 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; each instance of RK2 is independently hydrogen, halogen, substituted or unsubstituted, C1- 10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, – LK2–(substituted or unsubstituted carbocyclyl), –LK2–(substituted or unsubstituted heterocyclyl), –LK2–(substituted or unsubstituted aryl), –LK2–(substituted or unsubstituted heteroaryl), –ORN2, a latent-fluoride moiety, or –LK2–(a latent-fluoride moiety); each instance of LK2 is independently a single bond, –O–, substituted or unsubstituted, C1- 10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; each instance of RN2 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; or at least one instance of RK1 and at least one instance of RK2 that are attached to the same instance of Si are joined with the intervening atom to form substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, optionally wherein at least one substituent of the substituted carbocyclyl or substituted heterocyclyl is a latent-fluoride moiety; each instance of j is independently 1, 2, or 3; each instance of k is independently 0, 1, 2, or 3; and each instance of the latent-fluoride moiety comprises one or more through covalent bonds a, wherein each covalent bond a is cleavable in the presence of a degradation composition comprising one or more nucleophiles, one or more bases, or a combination thereof; provided that: at least one instance of the first monomer and/or at least one instance of the second monomer comprises at least one instance of the latent-fluoride moiety; and any two instances of the first monomer are the same as or different from each other, any two instances of the second monomer are the same as or different from each other, any two instances of the third monomer are the same as or different from each other, and each instance of the first monomer, the second monomer, and the third monomer if present, is different from each other. 4. A method of preparing a copolymer comprising polymerizing: one or more instances of a first monomer, wherein each instance of the first monomer independently comprises at least one C=C and/or at least one C≡C and optionally comprises one or more instances of a latent-fluoride moiety; one or more instances of a second monomer, wherein each instance of the second monomer is of Formula (B): (B), or a salt thereof; and optionally one or more instances of a third monomer; in the presence of a metathesis catalyst; wherein: each instance of Y is independently O or C(RQ)2; each instance of RQ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RY is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RZ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of RK1 is independently hydrogen, halogen, substituted or unsubstituted, C1- 10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, – LK1–(substituted or unsubstituted carbocyclyl), –LK1–(substituted or unsubstituted heterocyclyl), –LK1–(substituted or unsubstituted aryl), –LK1–(substituted or unsubstituted heteroaryl), –ORN1, a latent-fluoride moiety, or –LK1–(a latent-fluoride moiety); each instance of LK1 is independently a single bond, –O–, substituted or unsubstituted, C1- 10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; each instance of RN1 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; each instance of RK2 is independently hydrogen, halogen, substituted or unsubstituted, C1- 10 alkyl, substituted or unsubstituted, C2-10 alkenyl, substituted or unsubstituted, C2-10 alkynyl, – LK2–(substituted or unsubstituted carbocyclyl), –LK2–(substituted or unsubstituted heterocyclyl), –LK2–(substituted or unsubstituted aryl), –LK2–(substituted or unsubstituted heteroaryl), –ORN2, a latent-fluoride moiety, or –LK2–(a latent-fluoride moiety); each instance of LK2 is independently a single bond, –O–, substituted or unsubstituted, C1- 10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof; each instance of RN2 is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group; or at least one instance of RK1 and at least one instance of RK2 that are attached to the same instance of Si are joined with the intervening atom to form substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl, optionally wherein at least one substituent of the substituted carbocyclyl or substituted heterocyclyl is a latent-fluoride moiety; each instance of j is independently 1, 2, or 3; each instance of k is independently 0, 1, 2, or 3; and each instance of the latent-fluoride moiety comprises one or more through covalent bonds a, wherein each covalent bond a is cleavable in the presence of a degradation composition comprising one or more nucleophiles, one or more bases, or a combination thereof; provided that: at least one instance of the first monomer and/or at least one instance of the second monomer comprises at least one instance of the latent-fluoride moiety; and any two instances of the first monomer are the same as or different from each other, any two instances of the second monomer are the same as or different from each other, any two instances of the third monomer are the same as or different from each other, and each instance of the first monomer, the second monomer, and the third monomer if present, is different from each other. 5. The copolymer or method of any one of the preceding claims, wherein the at least one C=C and/or the at least one C≡C is a non-aromatic bond. 6. The copolymer or method of any one of the preceding claims, wherein at least one instance of the first monomer is of Formula (A): (A), or salt thereof, wherein each instance of Z is independently C(RP)2 or O; each instance of RP is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of is independently a single bond or double bond; each instance of RH is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –ORa, –OCN, –OC(=O)Ra, –OC(=S)Ra, – OC(=O)ORa, –OC(=O)N(Ra)2,–OS(=O)Ra, –OS(=O)ORa, –OS(=O)N(Ra)2, –OS(=O)2Ra, – OS(=O)2ORa, –OS(=O)2N(Ra)2, –OSi(Ra)3, –OSi(Ra)2(ORa), –OSi(Ra)(ORa)2, –OSi(ORa)3, oxo, – N(Ra)2, –N=C(Ra)2, =NRa, –NC, –NCO, –N3, –NO2, –NRaC(=O)Ra, –NRaC(=O)ORa, – NRaC(=O)N(Ra)2, –NRaS(=O)Ra, –NRaS(=O)ORa, –NRaS(=O)N(Ra)2, –NRaS(=O)2Ra, – NRaS(=O)2ORa, –NRaS(=O)2N(Ra)2, –SRa, –SCN, –S(=O)Ra, –S(=O)ORa, –S(=O)N(Ra)2, – S(=O)2Ra, –S(=O)2ORa, –S(=O)2N(Ra)2, –SeRa, –CN, –C(=NRa)Ra, –C(=NRa)ORa, – C(=NRa)N(Ra)2, –C(=O)Ra, –C(=O)ORa, –C(=O)SRa, –C(=S)ORa, –C(=O)N(Ra)2, or a latent- fluoride moiety; or the two instances of RH of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent of at least one instance of the substituted monocyclic carbocyclic ring, substituted monocyclic heterocyclic ring, substituted monocyclic aryl ring, or substituted monocyclic heteroaryl ring is a latent-fluoride moiety; each instance of Ra is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl; and each instance of the latent-fluoride moiety comprises one or more through covalent bonds a, wherein each covalent bond a is cleavable in the presence of a degradation composition comprising one or more nucleophiles, one or more bases, or a combination thereof. 7. The first monomer, copolymer, or method of any one of the preceding claims, wherein the two instances of RH of one or more instances of are joined with the intervening carbon atoms to independently form a substituted monocyclic heterocyclic ring, wherein at least one substituent of at least one instance of the substituted monocyclic heterocyclic is a latent- fluoride moiety. 8. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: late nt-fluoride moiety , or salt thereof, wherein each instance of LX is independently a single bond, substituted or unsubstituted, C1-10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof. 9. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: . 10. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: or salt thereof. 11. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: , or salt thereof, wherein each instance of g is independently 0, 1, or 2. 12. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: , or salt thereof. 13. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of LX is a single bond or substituted or unsubstituted, C1-10 alkylene. 14. The copolymer or method of any one of the preceding claims, wherein at least one instance of the first monomer is of the formula: preferably 15. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: latent-fluoride moiety , or a salt thereof. 16. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or a salt thereof. 17. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or salt thereof. 18. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or salt thereof, wherein each instance of g is independently 0, 1, or 2. 19. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or salt thereof. 20. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or a salt thereof. 21. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: latent-fluoride moiety , or a salt thereof. 22. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of LK1 is a single bond or substituted or unsubstituted, C1-10 alkylene. 23. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , or a salt thereof, wherein: each instance of h is independently an integer between 0 and 10, inclusive; and each instance of RK2 is independently substituted or unsubstituted, C1-10 alkyl; preferably unsubstituted C1-10 alkyl. 24. The second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: . 25. The copolymer or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: , 26. The copolymer or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: 27. The copolymer or method of any one of the preceding claims, wherein at least one instance of the second monomer is of the formula: . 28. The copolymer or method of any one of the preceding claims, wherein at least one instance of the third monomer is of Formula (C): or salt thereof, wherein each instance of Z is independently C(RP)2 or O; each instance of RP is independently hydrogen, halogen, or substituted or unsubstituted, C1-6 alkyl; each instance of is independently a single bond or double bond; each instance of RG is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –ORa, –OCN, –OC(=O)Ra, –OC(=S)Ra, – OC(=O)ORa, –OC(=O)N(Ra)2,–OS(=O)Ra, –OS(=O)ORa, –OS(=O)N(Ra)2, –OS(=O)2Ra, – OS(=O)2ORa, –OS(=O)2N(Ra)2, –OSi(Ra)3, –OSi(Ra)2(ORa), –OSi(Ra)(ORa)2, –OSi(ORa)3, oxo, – N(Ra)2, –N=C(Ra)2, =NRa, –NC, –NCO, –N3, –NO2, –NRaC(=O)Ra, –NRaC(=O)ORa, – NRaC(=O)N(Ra)2, –NRaS(=O)Ra, –NRaS(=O)ORa, –NRaS(=O)N(Ra)2, –NRaS(=O)2Ra, – NRaS(=O)2ORa, –NRaS(=O)2N(Ra)2, –SRa, –SCN, –S(=O)Ra, –S(=O)ORa, –S(=O)N(Ra)2, – S(=O)2Ra, –S(=O)2ORa, –S(=O)2N(Ra)2, –SeRa, –CN, –C(=NRa)Ra, –C(=NRa)ORa, – C(=NRa)N(Ra)2, –C(=O)Ra, –C(=O)ORa, –C(=O)SRa, –C(=S)ORa, –C(=O)N(Ra)2, or a latent- fluoride moiety; or the two instances of RG of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent on the monocyclic, carbocyclic, heterocyclic, aryl, or heteroaryl ring is substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2- 1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, – C(=NRa)Ra, –C(=NRa)ORa, –C(=NRa)N(Ra)2, –C(=O)Ra, –C(=O)ORa, –C(=O)N(Ra)2, or a nitrogen protecting group when attached to a nitrogen atom; and each instance of Ra is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of Ra are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl. 29. The copolymer or method of any one of the preceding claims, wherein the two instances of RG of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent on the monocyclic, carbocyclic, heterocyclic, aryl, or heteroaryl ring is substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2-1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, –C(=NRa)Ra, –C(=NRa)ORa, – C(=NRa)N(Ra)2, –C(=O)Ra, –C(=O)ORa, –C(=O)N(Ra)2, or a nitrogen protecting group when attached to a nitrogen atom. 30. The copolymer or method of any one of the preceding claims, wherein the two instances of RG of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, or substituted or unsubstituted, monocyclic heterocyclic ring, optionally wherein at least one substituent on the monocyclic, carbocyclic or heterocyclic ring is substituted or unsubstituted, C1-1000 alkyl or substituted or unsubstituted, C1-1000 heteroalkyl. 31. The copolymer or method of the preceding claim, wherein at least one instance of the third monomer is of the formula: , or salt thereof, wherein each instance of RX is independently substituted or unsubstituted, C1-1000 alkyl, substituted or unsubstituted, C2-1000 alkenyl, substituted or unsubstituted, C2-1000 alkynyl, substituted or unsubstituted, C1-1000 heteroalkyl, substituted or unsubstituted, C2-1000 heteroalkenyl, substituted or unsubstituted, C2-1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, –C(=NRa)Ra, –C(=NRa)ORa, –C(=NRa)N(Ra)2, – C(=O)Ra, –C(=O)ORa, –C(=O)N(Ra)2, or a nitrogen protecting group. 32. The copolymer or method of the preceding claim, wherein at least one RX is substituted or unsubstituted, C1-1000 alkyl or substituted or unsubstituted, C1-1000 heteroalkyl. 33. The copolymer or method of any one of the preceding claims, wherein at least one RX is C1-1000 alkyl substituted with one or more fluoro. 34. The copolymer or method of any one of the preceding claims, wherein at least one RX is , wherein: n is an integer from 1 to 300, inclusive; and RF is hydrogen, substituted or unsubstituted, C1-6 alkyl, or an oxygen protecting group. 35. The copolymer or method of any one of the preceding claims, wherein at least one instance of RG is hydrogen. 36. The copolymer or method of any one of the preceding claims, wherein at least one instance of the third monomer is of the formula: . 37. The copolymer or method of any one of the preceding claims, wherein at least one instance of the third monomer is of Formula (D1): or a salt thereof. 38. The copolymer or method of any one of the preceding claims, wherein at least one instance of the third monomer is of Formula (D2): or a salt thereof, wherein: each instance of x is independently 0, 1, or 2; and each instance of y is independently 0, 1, or 2. 39. The copolymer or method of any one of the preceding claims, wherein at least one instance of the third monomer is of the formula: preferably 40. The first monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of Z is CH2. 41. The first monomer, copolymer, or method of any one of the preceding claims, wherein each instance of is a single bond. 42. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one covalent bond a is cleavable in the presence of the degradation composition through an intermolecular substitution reaction. 43. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the latent-fluoride moiety is –L–pentafluorophenyl, wherein each instance of L is independently a single bond, –O–, substituted or unsubstituted, C1- 10 alkylene, substituted or unsubstituted, C2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof. 44. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the latent-fluoride moiety is pentafluorophenyl. 45. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the latent-fluoride moiety is –C(=O)F, –S(=O)F, or – S(=O)2F. 46. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one covalent bond a is cleavable in the presence of the degradation composition through an intramolecular substitution reaction. 47. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the latent-fluoride moiety is of the formula: , wherein g is 0, 1, or 2. 48. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one covalent bond a is cleavable in the presence of the degradation composition through a Hofmann elimination reaction. 49. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the latent-fluoride moiety is –CHF–CH3. 50. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the first monomer comprises at least one instance of the latent-fluoride moiety. 51. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of the second monomer comprises at least one instance of the latent-fluoride moiety. 52. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one instance of RX comprises at least one instance of the latent-fluoride moiety. 53. A method of degrading a copolymer of any one of the preceding claims comprising contacting the copolymer with the degradation composition, wherein at least one covalent bond a is cleaved. 54. The copolymer or method of any one of the preceding claims, wherein the one or more nucleophiles, one or more bases, or combination thereof is the combination. 55. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one nucleophile is a thiol. 56. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one nucleophile is a thiol of the formula: RS–SH, and RS is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, cysteine, a peptide, or a protein, wherein the peptide and protein comprise at least one cysteine optionally protected at the C or N terminus. 57. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one nucleophile is C2-12 alkanethiol, e.g., 1-n-octanethiol. 58. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one nucleophile is C12-18 alkanethiol, e.g., 1-n-dodecanethiol. 59. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one nucleophile is cysteine, a peptide, or a protein, wherein the peptide and protein comprise at least one cysteine optionally protected at the C or N terminus. 60. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one base is an alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal carbonate, or alkaline earth metal bicarbonate, e.g., Cs2CO3. 61. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one base is a non-nucleophilic organic base. 62. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one base is a non-aromatic amine or aromatic amine. 63. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one base is 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU); 1,5- diazabicyclo[4.3.0]non-5-ene (DBN); triethylamine, N,N-diisopropylethylamine (DIPEA); or 2,6-di-tert-butylpyridine. 64. The copolymer or method of any one of the preceding claims, wherein the degradation composition further comprises a solvent. 65. The copolymer or method of any one of the preceding claims, wherein the solvent is an aprotic organic solvent comprising at least one heteroatom or a mixture of aprotic organic solvents independently comprising at least one heteroatom. 66. The copolymer or method of any one of the preceding claims, wherein the solvent is tetrahydrofuran, 2-methyltetrahydrofuran, 1,4-dioxane, cyclopentyl methyl ether, tert-butyl methyl ether, or a mixture thereof. 67. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one covalent bond a is cleavable in the presence of the degradation composition under physiological conditions. 68. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein the half life of at least one covalent bond a in the presence of at least one nucleophile at the concentration of about 1 molar and/or at least one base at the concentration of about 1 molar under physiological conditions is between 1 and 10 minutes, between 10 and 60 minutes, between 1 and 3 hours, between 3 and 8 hours, between 8 and 24 hours, between 1 and 3 days, or between 3 and 7 days, inclusive. 69. The first monomer, second monomer, copolymer, or method of any one of the preceding claims, wherein at least one covalent bond a is cleavable in the presence of the degradation composition at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm. 70. The copolymer or method of any one of the preceding claims, wherein the molar ratio of the one or more instances of the first monomer to the one or more instances of the second monomer is between 0.1:1 and 0.3:1, between 0.3:1 and 1:1, between 1:1 and 3:1, between 3:1 and 10:1, between 10:1 and 30:1, or between 30:1 and 100:1, inclusive; preferably between 0.3:1 and 10:1, inclusive. 71. The copolymer or method of any one of the preceding claims, wherein the step of polymerizing is ring-opening metathesis polymerization. 72. The copolymer or method of any one of the preceding claims, wherein the metathesis catalyst is a ruthenium metathesis catalyst. 73. The copolymer or method of any one of the preceding claims, wherein the metathesis catalyst is a Grubbs catalyst. 74. The copolymer or method of any one of the preceding claims, wherein the molar ratio of the one or more instances of the third monomer, if present, to the one or more instances of the second monomer is between 0.3:1 and 1:1, between 1:1 and 3:1, between 3:1 and 10:1, between 10:1 and 30:1, between 30:1 and 100:1, or between 100:1 and 300:1, inclusive; preferably between 3:1 and 30:1, inclusive. 75. The copolymer or method of any one of the preceding claims, wherein the molar ratio of the combined amounts of the first monomer, second monomer, and third monomer if present to the amount of the metathesis catalyst is between 3:1 and 10:1, between 10:1 and 100:1, between 100:1 and 1,000:1, between 1,000:1 and 10,000:1, or between 10,000:1 and 100,000:1, inclusive; preferably between 10:1 and 1,000:1, inclusive. 76. The copolymer or method of any one of the preceding claims, wherein the copolymer is crosslinked, and the crosslinking degree is between 0.1% and 0.3%, between 0.3% and 1%, between 1% and 3%, between 3% and 10%, between 10% and 20%, or between 20% and 50%, inclusive, mole:mole; preferably, between 1% and 10%, inclusive, mole:mole. 77. The copolymer or method of any one of the preceding claims, wherein the number- average molecular weight of the copolymer as determined by gel permeation chromatography is between 10 kDa and 100 kDa, between 100 kDa and 1,000 kDa, between 1,000 kDa and 10,000 kDa, or between 10,000 kDa and 100,000 kDa, inclusive. 78. The copolymer or method of any one of the preceding claims, wherein the copolymer is a block copolymer, preferably a block copolymer comprising at least four consecutive blocks, wherein: each of the first consecutive block and the third consecutive block independently comprises one or more repeating units formed from the first monomer or the third monomer if present; and each of the second consecutive block and the fourth consecutive block independently comprises one or more repeating units formed from the second monomer. 79. The copolymer or method of any one of the preceding claims, wherein the copolymer is a random copolymer. 80. The copolymer or method of any one of the preceding claims, wherein the step of polymerizing is substantially free of a chain transfer agent. 81. The copolymer or method of any one of the preceding claims, wherein the copolymer comprises one or more pharmaceutical agents, wherein the pharmaceutical agents are covalently attached to the copolymer. 82. The copolymer or method of claim 81, wherein at least one of the pharmaceutical agents is a therapeutic agent. 83. The copolymer or method of claim 81, wherein at least one of the pharmaceutical agents is an anti-cancer agent. 84. The copolymer or method of claim 81, wherein at least one of the pharmaceutical agents is a prophylactic agent. 85. The copolymer or method of claim 81, wherein at least one of the pharmaceutical agents is a diagnostic agent. 86. The copolymer or method of claim 81, wherein at least one of the pharmaceutical agents is a contrast agent. 87. A composition comprising: the copolymer of any one of the preceding claims; and optionally an excipient. 88. The composition of claim 87, wherein the composition is an adhesive composition. 89. The composition of claim 87, wherein the composition is a coating composition. 90. The composition of claim 87 comprising: the copolymer; and optionally a pharmaceutically acceptable excipient. 91. A kit comprising: the copolymer of any one of the preceding claims; and instructions for using the copolymer. 92. A method of delivering a pharmaceutical agent to a subject in need thereof comprising administering to the subject in need thereof an effective amount of the copolymer of claim 81 or . 93. A method of treating a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer of claim 82 or 83. 94. A method of preventing a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer of claim 84. 95. A method of diagnosing a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer of claim 85 or 86. 96. The method of any one of claims 93-95, wherein the disease is cancer. 97. The method of any one of claims 92-96, wherein the subject is a human. |
, or salt thereof, wherein each instance of g is independently 0, 1, or 2. In certain embodiments, at least one instance of the second monomer is of the formula: , or salt thereof. In certain embodiments, at least one instance of the second monomer is of the formula: , or a salt thereof. In certain embodiments, at least one instance of the second monomer is of the formula: latent-fluoride moiety , or a salt thereof. In certain embodiments, at least one instance of L K1 is a single bond or substituted or unsubstituted, C 1-10 alkylene. In certain embodiments, at least one instance of L K1 is a single bond. In certain embodiments, at least one instance of L K1 is substituted or unsubstituted, C 2-10 heteroalkylene. In certain embodiments, at least one instance of L K1 is –O– or substituted or unsubstituted, C 1-10 alkylene. In certain embodiments, at least one instance of L K1 is substituted or unsubstituted phenylene. In certain embodiments, Y is O. In certain embodiments, Y is CH 2 . In certain embodiments, at least one instance of R Y is hydrogen. In certain embodiments, at least one instance of R Y is unsubstituted C 1-6 alkyl (e.g., Me). In certain embodiments, at least one instance of R Z is hydrogen. In certain embodiments, at least one instance of R Z is unsubstituted C 1-6 alkyl (e.g., Me). In certain embodiments, the at least one C=C and/or the at least one C≡C is a non- aromatic bond. In certain embodiments, at least one instance of R K1 is substituted or unsubstituted, C 1-10 alkyl. In certain embodiments, at least one instance of R K1 is unsubstituted methyl, unsubstituted ethyl, unsubstituted propyl (e.g., unsubstituted n-propyl or unsubstituted isopropyl), or unsubstituted butyl (e.g., unsubstituted n-butyl). In certain embodiments, at least one instance of R K1 is substituted or unsubstituted, saturated carbocyclyl. In certain embodiments, at least one instance of R K1 is unsubstituted cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl, unsubstituted cyclohexyl, or unsubstituted cycloheptyl. In certain embodiments, at least one instance of R K1 is substituted or unsubstituted, partially unsaturated carbocyclyl. In certain embodiments, at least one instance of R K1 is substituted or unsubstituted carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system. In certain embodiments, at least one instance of R K1 is unsubstituted cyclobutenyl, unsubstituted cyclopentenyl, unsubstituted cyclohexenyl, or unsubstituted cycloheptenyl. In certain embodiments, at least one instance of R K1 is substituted or unsubstituted carbocyclyl that comprises only two unsaturated bonds in the carbocyclic ring system. In certain embodiments, at least one instance of R K1 is substituted or unsubstituted carbocyclyl that comprises no C≡C bonds in the carbocyclic ring system. In certain embodiments, at least one instance of R K1 is: wherein: Ring B’, wherein Ring B’ is a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring; Z’ is C(R P’ ) 2 or O; each instance of R P’ is independently hydrogen, halogen, or substituted or unsubstituted, C 1-6 alkyl; is a single bond or double bond; each instance of R H’ is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –OR a , –OCN, –OC(=O)R a , –OC(=S)R a , – OC(=O)OR a , –OC(=O)N(R a ) 2 ,–OS(=O)R a , –OS(=O)OR a , –OS(=O)N(R a ) 2 , –OS(=O) 2 R a , – OS(=O) 2 OR a , –OS(=O) 2 N(R a ) 2 , –OSi(R a ) 3 , –OSi(R a ) 2 (OR a ), –OSi(R a )(OR a ) 2 , –OSi(OR a ) 3 , oxo, – N(R a ) 2 , –N=C(R a ) 2 , =NR a , –NC, –NCO, –N 3 , –NO 2 , –NR a C(=O)R a , –NR a C(=O)OR a , – NR a C(=O)N(R a ) 2 , –NR a S(=O)R a , –NR a S(=O)OR a , –NR a S(=O)N(R a ) 2 , –NR a S(=O) 2 R a , – NR a S(=O) 2 OR a , –NR a S(=O) 2 N(R a ) 2 , –SR a , –SCN, –S(=O)R a , –S(=O)OR a , –S(=O)N(R a ) 2 , – S(=O) 2 R a , –S(=O) 2 OR a , –S(=O) 2 N(R a ) 2 , ,–SeR a , halogen, –CN, –C(=NR a )R a , –C(=NR a )OR a , – C(=NR a )N(R a ) 2 , –C(=O)R a , –C(=O)OR a , –C(=O)SR a , –C(=S)OR a , or –C(=O)N(R a ) 2 ; or the two instances of R H’ are joined with the intervening carbon atoms to form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring; and each instance of R a is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R a are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl. In certain embodiments, at least one instance of R K1 is: In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic carbocyclic ring. In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic, saturated carbocyclyl. In certain embodiments, Ring B’ is unsubstituted cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl, unsubstituted cyclohexyl, or unsubstituted cycloheptyl. In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic, partially unsaturated carbocyclyl. In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system. In certain embodiments, Ring B’ is unsubstituted cyclobutenyl, unsubstituted cyclopentenyl, unsubstituted cyclohexenyl, or unsubstituted cycloheptenyl. In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic carbocyclyl that comprises only two unsaturated bonds in the carbocyclic ring system. In certain embodiments, Ring B’ is substituted or unsubstituted, monocyclic carbocyclyl that comprises no C≡C bonds in the carbocyclic ring system. In certain embodiments, Z’ is CH 2 . In certain embodiments, each R H’ is hydrogen. In certain embodiments, two instances of R H’ are joined with the intervening carbon atoms to form an unsubstituted monocyclic carbocyclic ring. In certain embodiments, two instances of R H’ are joined with the intervening carbon atoms to form an unsubstituted monocylic heterocyclic ring. In certain embodiments, at least one instance of R K1 is . In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted, C 1- 10 alkylene)–(substituted or unsubstituted, partially unsaturated carbocyclyl). In certain embodiments, at least one instance of R K1 is –(unsubstituted C 1-10 alkylene)–(substituted or unsubstituted carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system). In certain embodiments, at least one instance of R K1 is substituted or unsubstituted heterocyclyl or –L K1 –(substituted or unsubstituted heterocyclyl). In certain embodiments, at least one instance of R K1 is substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system or –L K1 –(substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K1 is – (substituted or unsubstituted, C 1-10 alkylene)–(substituted or unsubstituted heterocyclyl). In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted, C 1-10 alkylene)–(substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted, partially unsaturated heterocyclyl). In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted phenylene)– (substituted or unsubstituted heterocyclyl that comprises only one unsaturated bond in the heterocyclic ring system). In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted, partially unsaturated heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K1 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted heterocyclyl that comprises O–Si and only one unsaturated bond in the heterocyclic ring system). In certain embodiments, at least one instance of R K1 is In certain embodiments, at least one instance of R K1 is In certain embodiments, at least one instance of R K1 is hydrogen. In certain embodiments, at least one instance of R K1 is –OR N1 (e.g., –O(substituted or unsubstituted, C 1-10 alkyl)). In certain embodiments, at least one first instance of R K of a second monomer is –OR N (e.g., –O(substituted or unsubstituted, C 1-10 alkyl)). In certain embodiments, at least one instance of R N1 is substituted or unsubstituted, C 1-10 alkyl. In certain embodiments, at least one instance of R N1 is unsubstituted C 1-6 alkyl. In certain embodiments, at least one instance of R K2 is substituted or unsubstituted, saturated carbocyclyl. In certain embodiments, at least one instance of R K2 is unsubstituted cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl, unsubstituted cyclohexyl, or unsubstituted cycloheptyl. In certain embodiments, at least one instance of R K2 is substituted or unsubstituted, partially unsaturated carbocyclyl. In certain embodiments, at least one instance of R K2 is substituted or unsubstituted carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system. In certain embodiments, at least one instance of R K2 is unsubstituted cyclobutenyl, unsubstituted cyclopentenyl, unsubstituted cyclohexenyl, or unsubstituted cycloheptenyl. In certain embodiments, at least one instance of R K2 is substituted or unsubstituted carbocyclyl that comprises only two unsaturated bonds in the carbocyclic ring system. In certain embodiments, at least one instance of R K2 is substituted or unsubstituted carbocyclyl that comprises no C≡C bonds in the carbocyclic ring system. In certain embodiments, at least one instance of R K2 is: wherein: is Ring B”, wherein Ring B” is a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring; Z” is C(R P” ) 2 or O; each instance of R P” is independently hydrogen, halogen, or substituted or unsubstituted, C 1-6 alkyl; is a single bond or double bond; each instance of R H” is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –OR a , –OCN, –OC(=O)R a , –OC(=S)R a , – OC(=O)OR a , –OC(=O)N(R a ) 2 ,–OS(=O)R a , –OS(=O)OR a , –OS(=O)N(R a ) 2 , –OS(=O) 2 R a , – OS(=O) 2 OR a , –OS(=O) 2 N(R a ) 2 , –OSi(R a ) 3 , –OSi(R a ) 2 (OR a ), –OSi(R a )(OR a ) 2 , –OSi(OR a ) 3 , oxo, – N(R a ) 2 , –N=C(R a ) 2 , =NR a , –NC, –NCO, –N 3 , –NO 2 , –NR a C(=O)R a , –NR a C(=O)OR a , – NR a C(=O)N(R a ) 2 , –NR a S(=O)R a , –NR a S(=O)OR a , –NR a S(=O)N(R a ) 2 , –NR a S(=O) 2 R a , – NR a S(=O) 2 OR a , –NR a S(=O) 2 N(R a ) 2 , –SR a , –SCN, –S(=O)R a , –S(=O)OR a , –S(=O)N(R a ) 2 , – S(=O) 2 R a , –S(=O) 2 OR a , –S(=O) 2 N(R a ) 2 , ,–SeR a , halogen, –CN, –C(=NR a )R a , –C(=NR a )OR a , – C(=NR a )N(R a ) 2 , –C(=O)R a , –C(=O)OR a , –C(=O)SR a , –C(=S)OR a , or –C(=O)N(R a ) 2 ; or the two instances of R H” are joined with the intervening carbon atoms to form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring; and each instance of R a is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R a are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl. In certain embodiments, at least one instance of R K2 is: In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic carbocyclic ring. In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic, saturated carbocyclyl. In certain embodiments, Ring B” is unsubstituted cyclopropyl, unsubstituted cyclobutyl, unsubstituted cyclopentyl, unsubstituted cyclohexyl, or unsubstituted cycloheptyl. In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic, partially unsaturated carbocyclyl. In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system. In certain embodiments, Ring B” is unsubstituted cyclobutenyl, unsubstituted cyclopentenyl, unsubstituted cyclohexenyl, or unsubstituted cycloheptenyl. In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic carbocyclyl that comprises only two unsaturated bonds in the carbocyclic ring system. In certain embodiments, Ring B” is substituted or unsubstituted, monocyclic carbocyclyl that comprises no C≡C bonds in the carbocyclic ring system. In certain embodiments, Z” is CH 2 . In certain embodiments, each R H” is hydrogen. In certain embodiments, two instances of R H” are joined with the intervening carbon atoms to form an unsubstituted monocyclic carbocyclic ring. In certain embodiments, two instances of R H” are joined with the intervening carbon atoms to form an unsubstituted monocylic heterocyclic ring. In certain embodiments, at least one instance of R K2 is In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted, C 1- 10 alkylene)–(substituted or unsubstituted, partially unsaturated carbocyclyl). In certain embodiments, at least one instance of R K2 is –(unsubstituted C 1-10 alkylene)–(substituted or unsubstituted carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system). In certain embodiments, at least one instance of R K2 is substituted or unsubstituted heterocyclyl or –L K2 –(substituted or unsubstituted heterocyclyl). In certain embodiments, at least one instance of R K2 is substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system or –L K2 –(substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K2 is – (substituted or unsubstituted, C 1-10 alkylene)–(substituted or unsubstituted heterocyclyl). In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted, C 1-10 alkylene)–(substituted or unsubstituted heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted, partially unsaturated heterocyclyl). In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted phenylene)– (substituted or unsubstituted heterocyclyl that comprises only one unsaturated bond in the heterocyclic ring system). In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted, partially unsaturated heterocyclyl that comprises O–Si in the heterocyclic ring system). In certain embodiments, at least one instance of R K2 is –(substituted or unsubstituted phenylene)–(substituted or unsubstituted heterocyclyl that comprises O–Si and only one unsaturated bond in the heterocyclic ring system). In certain embodiments, at least one instance of R K2 is In certain embodiments, at least one instance of R K2 is , , , In certain embodiments, at least one instance of R K2 is hydrogen. In certain embodiments, at least one instance of R K2 is –OR N2 (e.g., –O(substituted or unsubstituted, C 1-10 alkyl)). In certain embodiments, at least one instance of R N2 is substituted or unsubstituted, C 1-10 alkyl. In certain embodiments, at least one instance of R N2 is unsubstituted C 1-6 alkyl. In certain embodiments, at least one instance of L K2 is –O– or substituted or unsubstituted, C 1-10 alkylene. In certain embodiments, at least one instance of L K2 is unsubstituted C 1-6 alkylene. In certain embodiments, at least one instance of L K2 is substituted or unsubstituted phenylene. In certain embodiments, at least one second instance of R K of the second monomer is substituted or unsubstituted, C 1-10 alkyl. In certain embodiments, at least one second instance of R K of the second monomer is unsubstituted methyl, unsubstituted ethyl, unsubstituted propyl (e.g., unsubstituted n-propyl or unsubstituted isopropyl), or unsubstituted butyl (e.g., unsubstituted n-butyl). In certain embodiments, at least one second instance of R K of the second monomer is substituted or unsubstituted phenyl. In certain embodiments, at least one second instance of R K of the second monomer is –OR N (e.g., –O(substituted or unsubstituted, C 1-10 alkyl)). In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, partially unsaturated carbocyclyl. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, monocyclic carbocyclyl that comprises only one unsaturated bond in the carbocyclic ring system. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form unsubstituted cyclobutenyl, unsubstituted cyclopentenyl, unsubstituted cyclohexenyl, or unsubstituted cycloheptenyl. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, monocyclic carbocyclyl that comprises only two unsaturated bonds in the carbocyclic ring system. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted carbocyclyl that comprises no C≡C bonds in the carbocyclic ring system. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, partially unsaturated heterocyclyl. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, monocyclic heterocyclyl that comprises only one unsaturated bond in the heterocyclic ring system. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted, monocyclic heterocyclyl that comprises only two unsaturated bonds in the heterocyclic ring system. In certain embodiments, R K1 and R K2 of at least one instance of the second monomer are joined with the intervening atom to form substituted or unsubstituted heterocyclyl that comprises no C≡C bonds in the heterocyclic ring system. In certain embodiments, at least one instance of the second monomer comprises only one non-aromatic unsaturated bond. In certain embodiments, each instance of the second monomer comprises only one non-aromatic unsaturated bond. In certain embodiments, at least one instance of the second monomer comprises only two non-aromatic unsaturated bonds. In certain embodiments, the C=C bond in the heterocyclic ring that comprises O–Si–Y is of the (Z)-configuration. In certain embodiments, the C=C bond in the heterocyclic ring that comprises O–Si–Y is of the (E)-configuration. In certain embodiments, j is 1. In certain embodiments, j is 2. In certain embodiments, j is 3. In certain embodiments, k is 1. In certain embodiments, k is 2. In certain embodiments, k is 3. In certain embodiments, k is 0. In certain embodiments, j is 1, and k is 1. In certain embodiments, j is 1, and k is 2. In certain embodiments, j is 1, and k is 2 or 3. In certain embodiments, j is 2, and k is 1. In certain embodiments, at least one instance of the second monomer is of the formula: , or a salt thereof, wherein: each instance of h is independently an integer between 0 and 10, inclusive; and each instance of R K2 is independently substituted or unsubstituted, C 1-10 alkyl; preferably unsubstituted C 1-10 alkyl. In certain embodiments, at least one instance of the second monomer is of the formula: . In certain embodiments, at least one instance of the second monomer is of the formula: O , In certain embodiments, at least one instance of the second monomer is of the formula: In certain embodiments, at least one instance of the second monomer is of the formula: . In certain embodiments, at least one instance of the third monomer is of Formula (C): or salt thereof, wherein each instance of Z is independently C(R P ) 2 or O; each instance of R P is independently hydrogen, halogen, or substituted or unsubstituted, C 1-6 alkyl; each instance of is independently a single bond or double bond; each instance of R G is independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, –OR a , –OCN, –OC(=O)R a , –OC(=S)R a , – OC(=O)OR a , –OC(=O)N(R a ) 2 ,–OS(=O)R a , –OS(=O)OR a , –OS(=O)N(R a ) 2 , –OS(=O) 2 R a , – OS(=O) 2 OR a , –OS(=O) 2 N(R a ) 2 , –OSi(R a ) 3 , –OSi(R a ) 2 (OR a ), –OSi(R a )(OR a ) 2 , –OSi(OR a ) 3 , oxo, – N(R a ) 2 , –N=C(R a ) 2 , =NR a , –NC, –NCO, –N 3 , –NO 2 , –NR a C(=O)R a , –NR a C(=O)OR a , – NR a C(=O)N(R a ) 2 , –NR a S(=O)R a , –NR a S(=O)OR a , –NR a S(=O)N(R a ) 2 , –NR a S(=O) 2 R a , – NR a S(=O)2OR a , –NR a S(=O)2N(R a )2, –SR a , –SCN, –S(=O)R a , –S(=O)OR a , –S(=O)N(R a )2, – S(=O) 2 R a , –S(=O) 2 OR a , –S(=O) 2 N(R a ) 2 , –SeR a , –CN, –C(=NR a )R a , –C(=NR a )OR a , – C(=NR a )N(R a ) 2 , –C(=O)R a , –C(=O)OR a , –C(=O)SR a , –C(=S)OR a , –C(=O)N(R a ) 2 , or a latent- fluoride moiety; or the two instances of R G of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent on the monocyclic, carbocyclic, heterocyclic, aryl, or heteroaryl ring is substituted or unsubstituted, C 1 - 1000 alkyl, substituted or unsubstituted, C 2 - 1000 alkenyl, substituted or unsubstituted, C 2 - 1000 alkynyl, substituted or unsubstituted, C 1 - 1000 heteroalkyl, substituted or unsubstituted, C 2 - 1000 heteroalkenyl, substituted or unsubstituted, C 2 - 1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, – C(=NR a )R a , –C(=NR a )OR a , –C(=NR a )N(R a ) 2 , –C(=O)R a , –C(=O)OR a , –C(=O)N(R a ) 2 , or a nitrogen protecting group when attached to a nitrogen atom; and each instance of R a is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted, monocyclic carbocyclyl, substituted or unsubstituted, monocyclic heterocyclyl, substituted or unsubstituted, monocyclic aryl, substituted or unsubstituted, monocyclic heteroaryl, a nitrogen protecting group when attached to a nitrogen atom, an oxygen protecting group when attached to an oxygen atom, or a sulfur protecting group when attached to a sulfur atom, or two instances of R a are joined to form substituted or unsubstituted heterocyclyl or substituted or unsubstituted heteroaryl. In certain embodiments, the two instances of R G of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, substituted or unsubstituted, monocyclic heterocyclic ring, substituted or unsubstituted, monocyclic aryl ring, or substituted or unsubstituted, monocyclic heteroaryl ring, optionally wherein at least one substituent on the monocyclic, carbocyclic, heterocyclic, aryl, or heteroaryl ring is substituted or unsubstituted, C 1 - 1000 alkyl, substituted or unsubstituted, C 2 - 1000 alkenyl, substituted or unsubstituted, C 2 - 1000 alkynyl, substituted or unsubstituted, C 1 - 1000 heteroalkyl, substituted or unsubstituted, C 2 - 1000 heteroalkenyl, substituted or unsubstituted, C 2 - 1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, –C(=NR a )R a , –C(=NR a )OR a , –C(=NR a )N(R a ) 2 , – C(=O)R a , –C(=O)OR a , –C(=O)N(R a ) 2 , or a nitrogen protecting group when attached to a nitrogen atom. In certain embodiments, the two instances of R G of one or more instances of are joined with the intervening carbon atoms to independently form a substituted or unsubstituted, monocyclic carbocyclic ring, or substituted or unsubstituted, monocyclic heterocyclic ring, optionally wherein at least one substituent on the monocyclic, carbocyclic or heterocyclic ring is substituted or unsubstituted, C 1 - 1000 alkyl or substituted or unsubstituted, C 1 - 1000 heteroalkyl. In certain embodiments, at least one instance of the third monomer is of the formula: , or salt thereof, wherein each instance of R X is independently substituted or unsubstituted, C 1 - 1000 alkyl, substituted or unsubstituted, C 2 - 1000 alkenyl, substituted or unsubstituted, C 2 - 1000 alkynyl, substituted or unsubstituted, C 1 - 1000 heteroalkyl, substituted or unsubstituted, C 2 - 1000 heteroalkenyl, substituted or unsubstituted, C 2 - 1000 heteroalkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, –C(=NR a )R a , –C(=NR a )OR a , –C(=NR a )N(R a ) 2 , – C(=O)R a , –C(=O)OR a , –C(=O)N(R a ) 2 , or a nitrogen protecting group. In certain embodiments, at least one R X is substituted or unsubstituted, C 1 - 1000 alkyl or substituted or unsubstituted, C 1 - 1000 heteroalkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 1 - 10 alkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 11 - 18 alkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 19 - 100 alkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 101 - 1000 alkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 1 - 10 heteroalkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 2 - 10 heteroalkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 11 - 18 heteroalkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 19 - 100 heteroalkyl. In certain embodiments, at least one R X is substituted or unsubstituted, C 101 - 1000 heteroalkyl. In certain embodiments, at least one R X is C 1 - 1000 alkyl substituted with one or more fluoro. In certain embodiments, at least one R X is C 1 - 10 , C 11 - 18 , C 19 - 100 , or C 101 - 1000 , alkyl substituted with one or more fluoro. In certain embodiments, at least one R X is , wherein: n is an integer from 1 to 300, inclusive; and R F is hydrogen, substituted or unsubstituted, C 1-6 alkyl, or an oxygen protecting group. In certain embodiments, n is an integer between 1 and 3, between 3 and 10, between 10 and 30, between 30 and 100, or between 100 and 300, inclusive. In certain embodiments, R F is unsubstituted C 1-6 alkyl (e.g., Me). In certain embodiments, at least one instance of R G is hydrogen. In certain embodiments, at least one instance of R G is substituted or unsubstituted alkyl (e.g., –CF 3 ). In certain embodiments, at least one instance of R G is –CN. In certain embodiments, at least one instance of R G is –C(=O)OR a (e.g., –C(=O)OCH 3 ). In certain embodiments, at least one instance of R G is – C(=O)R a . In certain embodiments, at least one instance of R G is –C(=O)N(R a ) 2 . In certain embodiments, at least one instance of the third monomer is of the formula: Z Z R G G G G R or R R . In certain embodiments, at least one instance of the third monomer is of the formula: Z R G RG , or salt thereof. In certain embodiments, at least one instance of the third monomer is of Formula (D1): (D1), or a salt thereof. In certain embodiments, each instance of the third monomer is of Formula (D1), or a salt thereof. In certain embodiments, at least one instance of the third monomer is of the formula: . In certain embodiments, each instance of the third monomer is of the formula: . In certain embodiments, each instance of the third monomer is of the formula: . In certain embodiments, at least one instance of the third monomer is of Formula (D2): or a salt thereof, wherein: each instance of x is independently 0, 1, or 2; and each instance of y is independently 0, 1, or 2. In certain embodiments, each instance of the third monomer is of Formula (D2), or a salt thereof. In certain embodiments, at least one instance of the third monomer is of the formula: preferably In certain embodiments, each instance of the third monomer is of the formula: . In certain embodiments, each instance of the third monomer is of the formula: . In certain embodiments, each instance of the third monomer is of the formula: . In certain embodiments, at least one instance of the third monomer comprises one non- aromatic C=C or non-aromatic C≡C bond. In certain embodiments, at least one instance of the third monomer comprises two, three, or four non-aromatic C=C and/or non-aromatic C≡C bonds. In certain embodiments, at least one instance of the third monomer comprises two (i.e., only two) non-aromatic C=C and/or non-aromatic C≡C bonds. In certain embodiments, at least one instance of the third monomer comprises only three non-aromatic C=C and/or non-aromatic C≡C bonds (i.e., the combined number of non-aromatic C=C bonds and non-aromatic C≡C bonds is three). In certain embodiments, at least one instance of the third monomer comprises no C≡C bonds. In certain embodiments, at least one instance of Z is C(R P ) 2 . In certain embodiments, at least one instance of Z is CH 2 . In certain embodiments, at least one covalent bond a is cleavable in the presence of the degradation composition through an intermolecular substitution reaction. In certain embodiments, each instance of is a single bond. In another aspect, the present disclosure provides a method of degrading a copolymer of any one of the preceding claims comprising contacting the copolymer with the degradation composition, wherein at least one covalent bond a is cleaved. In certain embodiments, the one or more nucleophiles, one or more bases, or combination thereof is the combination. In certain embodiments, at least one instance of the latent-fluoride moiety is –L– pentafluorophenyl, wherein each instance of L is independently a single bond, –O–, substituted or unsubstituted, C 1-10 alkylene, substituted or unsubstituted, C 2-10 heteroalkylene, substituted or unsubstituted carbocyclylene, substituted or unsubstituted heterocyclylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, or a combination thereof. In certain embodiments, at least one instance of L is a single bond. In certain embodiments, at least one instance of L is substituted or unsubstituted, C 1-10 alkylene. In certain embodiments, at least one instance of L is substituted or unsubstituted, C 2-10 heteroalkylene. In certain embodiments, at least one instance of the latent-fluoride moiety is pentafluorophenyl. In certain embodiments, at least one instance of the latent-fluoride moiety is –C(=O)F, – S(=O)F, or –S(=O) 2 F. In certain embodiments, at least one covalent bond a is cleavable in the presence of the degradation composition through an intramolecular substitution reaction. In certain embodiments, at least one instance of the latent-fluoride moiety is of the formula: , wherein g is 0, 1, or 2. In certain embodiments, at least one instance of is . In certain embodiments, at least one instance of is In certain embodiments, at least one covalent bond a is cleavable in the presence of the degradation composition through a Hofmann elimination reaction. In certain embodiments, at least one instance of the latent-fluoride moiety is –CHF–CH 3 . In certain embodiments, at least one instance of the first monomer comprises at least one instance of the latent-fluoride moiety. In certain embodiments, no instance of the first monomer comprises at least one instance of the latent-fluoride moiety. In certain embodiments, at least one instance of the second monomer comprises at least one instance of the latent-fluoride moiety. In certain embodiments, no instance of the second monomer comprises at least one instance of the latent-fluoride moiety. In certain embodiments, no instance of the third monomer comprises at least one instance of the latent-fluoride moiety. In certain embodiments, at least one instance of R X comprises at least one instance of the latent-fluoride moiety. In certain embodiments, at least one nucleophile is a thiol. In certain embodiments, at least one nucleophile is a thiol of the formula: R S –SH, and R S is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, cysteine, a peptide, or a protein, wherein the peptide and protein comprise at least one cysteine optionally protected at the C or N terminus. In certain embodiments, at least one nucleophile is a thiol of the formula: R S –(substituted or unsubstituted alkyl). In certain embodiments, at least one nucleophile is C 2-12 alkanethiol, e.g., 1-n-octanethiol. In certain embodiments, at least one nucleophile is C 12-18 alkanethiol, e.g., 1-n- dodecanethiol. In certain embodiments, at least one nucleophile is C 2-4 n-alkanethiol. In certain embodiments, at least one nucleophile is C 5-7 n-alkanethiol. In certain embodiments, at least one nucleophile is C 8-12 n-alkanethiol. In certain embodiments, at least one nucleophile is C 13-18 n- alkanethiol. In certain embodiments, at least one nucleophile is cysteine, a peptide, or a protein, wherein the peptide and protein comprise at least one cysteine optionally protected at the C or N terminus. In certain embodiments, at least one base is an alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal carbonate, or alkaline earth metal bicarbonate, e.g., Cs 2 CO 3 . In certain embodiments, at least one base is Li 2 CO 3 , Na 2 CO 3 , K 2 CO 3 , (NH 4 ) 2 CO 3 , MgCO 3 , CaCO 3 , LiHCO 3 , NaHCO 3 , KHCO 3 , CsHCO 3 , (NH 4 )HCO 3 , Mg(HCO 3 ) 2 , or Ca(HCO 3 ) 2 . In certain embodiments, at least one base is a non-aromatic amine or aromatic amine. In certain embodiments, at least one base comprises no primary or secondary nitrogen atoms. In certain embodiments, at least one base is a non-aromatic tertiary amine comprising no primary or secondary nitrogen atoms. In certain embodiments, at least one base is of the formula: N(unsubstituted alkyl) 3 . In certain embodiments, at least one base is a non-aromatic tertiary amine comprising no primary or secondary nitrogen atoms, wherein at least one tertiary nitrogen atom is a ring atom of a monocyclic or polycyclic cycloalkyl ring. In certain embodiments, at least one base is a non-nucleophilic organic base. In certain embodiments, at least one base is 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU); 1,5-diazabicyclo[4.3.0]non-5-ene (DBN); triethylamine, N,N-diisopropylethylamine (DIPEA); or 2,6-di-tert-butylpyridine. In certain embodiments, at least one base is 1,5,7- triazabicyclo(4.4.0)dec-5-ene (TBD), 7-methyl-1,5,7-triazabicyclo(4.4.0)dec-5-ene (MTBD), 1,1,3,3-tetramethylguanidine (TMG), quinuclidine, 2,2,6,6-tetramethylpiperidine (TMP), pempidine, tri-n-butlyamine, 1,4-diazabicyclo[2.2.2]octan (TED), collidine, or 2,6-lutidine. In certain embodiments, the degradation composition further comprises a solvent. In certain embodiments, the solvent is substantially one single solvent. In certain embodiments, the solvent is a mixture of two or more (e.g., three) solvents (e.g., solvents described in this paragraph). In certain embodiments, the solvent is an organic solvent. In certain embodiments, the solvent is a non-aromatic organic solvent. In certain embodiments, the solvent is an aprotic organic solvent comprising at least one heteroatom or a mixture of aprotic organic solvents independently comprising at least one heteroatom. In certain embodiments, the solvent is tetrahydrofuran, 2-methyltetrahydrofuran, 1,4-dioxane, cyclopentyl methyl ether, tert-butyl methyl ether, or a mixture thereof. In certain embodiments, the solvent is acetone, methyl ethyl ketone, methyl isopropyl ketone, 2-pentanone, 3-pentanone, or a mixture thereof. In certain embodiments, the solvent is acetonitrile. In certain embodiments, the solvent is N,N- dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, or a mixture thereof. In certain embodiments, the boiling point of the solvent at 1 atm is between 50 and 60, between 60 and 80, between 80 and 100, between 100 and 130, between 130 and 160, or between 160 and 200 °C, inclusive. In certain embodiments, the copolymer swells in the solvent at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm. In certain embodiments, the copolymer is substantively insoluble in the solvent at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm. In certain embodiments, at least one covalent bond a is cleavable in the presence of the degradation composition under physiological conditions. In certain embodiments, at least one covalent bond a is cleavable in the presence of the degradation composition at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm. In certain embodiments, the half life of at least one covalent bond a in the presence of at least one nucleophile at the concentration of about 1 molar and/or at least one base at the concentration of about 1 molar under physiological conditions is between 1 and 10 minutes, between 10 and 60 minutes, between 1 and 3 hours, between 3 and 8 hours, between 8 and 24 hours, between 1 and 3 days, or between 3 and 7 days, inclusive. In certain embodiments, the half life of at least one covalent bond a in the presence of at least one nucleophile at the concentration of about 1 molar and at least one base at the concentration of about 1 molar under physiological conditions is between 10 minutes and 8 hours, inclusive. In certain embodiments, the half life of at least one covalent bond a in the presence of at least one nucleophile at the concentration of about 1 molar and/or at least one base at the concentration of about 1 molar at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm is between 1 and 10 minutes, between 10 and 60 minutes, between 1 and 3 hours, between 3 and 8 hours, between 8 and 24 hours, between 1 and 3 days, or between 3 and 7 days, inclusive. In certain embodiments, the half life of at least one covalent bond a in the presence of at least one nucleophile at the concentration of about 1 molar and at least one base at the concentration of about 1 molar at between 20 and 25 °C, inclusive, and 0.5 and 1.1 atm is between 10 minutes and 8 hours, inclusive. In certain embodiments, the molar ratio of the one or more instances of the first monomer to the one or more instances of the second monomer is between 0.1:1 and 0.3:1, between 0.3:1 and 1:1, between 1:1 and 3:1, between 3:1 and 10:1, between 10:1 and 30:1, or between 30:1 and 100:1, inclusive; preferably between 0.3:1 and 10:1, inclusive. In certain embodiments, the molar ratio of the one or more instances of the first monomer to the one or more instances of the second monomer is between 0.6:1 and 6:1, inclusive. In certain embodiments, the molar ratio of the one or more instances of the first monomer to the one or more instances of the second monomer is between 1:1 and 4:1, inclusive. In certain embodiments, the step of polymerizing is ring-opening metathesis polymerization (ROMP). Metathesis catalysts include catalysts as described herein and as described in Grubbs et al., Acc. Chem. Res.1995, 28, 446–452; U.S. Pat. No.5,811,515; Schrock et al., Organometallics (1982) 11645; Gallivan et al., Tetrahedron Letters (2005) 46:2577–2580; Furstner et al., J. Am. Chem. Soc. (1999) 121:9453; and Chem. Eur. J. (2001) 7:5299; the entire contents of each of which are incorporated herein by reference. In certain embodiments, the metathesis catalyst is ring-opening metathesis catalyst. In certain embodiments, the metathesis catalyst is a tungsten metathesis catalyst, molybdenum metathesis catalyst, or ruthenium metathesis catalyst. In certain embodiments, the metathesis catalyst is a ruthenium metathesis catalyst. In certain embodiments, the metathesis catalyst is a Grubbs catalyst. In certain embodiments, the Grubbs catalyst is selected from the group consisting of: X = Cl; Br; I C y = cyclohexyl ; Benzylidenebis– (tricyclohexylphosphine)–dichlororuthenium (X = Cl); Benzylidenebis– (tricyclohexylphosphine)–dibromoruthenium (X = Br); Benzylidenebis– (tricyclohexylphosphine)–diiodoruthenium (X = I); X = Cl; Br; I R = cyclohexyl (Cy); phenyl (Ph); benzyl (Bn) ; 1,3–(Bis(mesityl)–2–imidazolidinylidene)dichloro–(ph enylmethylene) (tricyclohexyl– phosphine)ruthenium (X = Cl; R = cyclohexyl); 1,3–(Bis(mesityl)–2– imidazolidinylidene)dibromo–(phenylmethylene) (tricyclohexyl–phosphine)ruthenium (X = Br; R = cyclohexyl); 1,3–(Bis(mesityl)–2–imidazolidinylidene)diiodo–(phen ylmethylene) (tricyclohexyl–phosphine)ruthenium (X = I; R = cyclohexyl); 1,3–(Bis(mesityl)–2– imidazolidinylidene)dichloro–(phenylmethylene) (triphenylphosphine)ruthenium (X = Cl; R = phenyl); 1,3–(Bis(mesityl)–2–imidazolidinylidene)dichloro–(ph enylmethylene) (tribenzylphosphine)ruthenium (X = Cl; R = benzyl);
In certain embodiments, the metathesis catalyst is a Grubbs-Hoveyda catalyst. In certain embodiments, the Grubbs-Hoveyda catalyst is selected from the group consisting of: In certain embodiments, the metathesis catalyst is selected from the group consisting of: Blechart Catalyst; Neolyst TM M1; and Furstner Catalyst. In certain embodiments, the metathesis catalyst is of the formula: . The ROMP can be conducted in one or more aprotic solvents. The term “aprotic solvent” means a non-nucleophilic solvent having a boiling point range above ambient temperature, preferably from about 25 ºC to about 190 ºC at atmospheric pressure. In certain embodiments, the aprotic solvent has a boiling point from about 80 ºC to about 160 ºC at atmospheric pressure. In certain embodiments, the aprotic solvent has a boiling point from about 80 ºC to about 150 ºC at atmospheric pressure. Examples of such solvents are methylene chloride, acetonitrile, toluene, DMF, diglyme, THF, and DMSO. The ROMP can be quenched with a vinyl ether of the formula . Each of R V1 , R V2 , R V3 , and R V4 is independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted phenyl, optionally substituted heterocyclyl, or optionally substituted heteroaryl. In certain embodiments, R V1 is optionally substituted alkyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is unsubstituted alkyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is substituted alkyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is methyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is ethyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is propyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is optionally substituted alkenyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is unsubstituted alkenyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, R V1 is vinyl, and R V2 , R V3 , and R V4 are hydrogen. In certain embodiments, at least one of R V1 , R V2 , R V3 , and R V4 is conjugated with a diagnostic agent as defined above. In certain embodiments, the ROMP is quenched by ethyl vinyl ether. Excess ethyl vinyl ether can be removed from the copolymer by vacuum. In certain embodiments, the molar ratio of the one or more instances of the third monomer, if present, to the one or more instances of the second monomer is between 0.3:1 and 1:1, between 1:1 and 3:1, between 3:1 and 10:1, between 10:1 and 30:1, between 30:1 and 100:1, or between 100:1 and 300:1, inclusive; preferably between 3:1 and 30:1, inclusive. In certain embodiments, the molar ratio of the one or more instances of the third monomer, if present, to the one or more instances of the second monomer is between 5:1 and 20:1, inclusive. In certain embodiments, the molar ratio of the combined amounts of the first monomer, second monomer, and third monomer if present to the amount of the metathesis catalyst is between 3:1 and 10:1, between 10:1 and 100:1, between 100:1 and 1,000:1, between 1,000:1 and 10,000:1, or between 10,000:1 and 100,000:1, inclusive; preferably between 10:1 and 1,000:1, inclusive. In certain embodiments, the molar ratio of the combined amounts of the first monomer, second monomer, and third monomer if present to the amount of the metathesis catalyst is between 30:1 and 100:1, between 100:1 and 300:1, between 300:1 and 1000:1, or between 1000:1 and 3000:1, inclusive. In certain embodiments, the copolymer is crosslinked, and the crosslinking degree is between 0.1% and 0.3%, between 0.3% and 1%, between 1% and 3%, between 3% and 10%, between 10% and 20%, or between 20% and 50%, inclusive, mole:mole; preferably, between 1% and 10%, inclusive, mole:mole. In certain embodiments, the copolymer is crosslinked, and the crosslinking degree is between 20% and 30%, between 30% and 40%, or between 40% and 50%, inclusive. In certain embodiments, the crosslinking degree is an average crosslinking degree determined by swelling measurements. In certain embodiments, the number-average molecular weight of the copolymer as determined by gel permeation chromatography is between 10 kDa and 100 kDa, between 100 kDa and 1,000 kDa, between 1,000 kDa and 10,000 kDa, or between 10,000 kDa and 100,000 kDa, inclusive. In certain embodiments, the copolymer is a block copolymer, preferably a block copolymer comprising at least four consecutive blocks, wherein: each of the first consecutive block and the third consecutive block independently comprises one or more repeating units formed from the first monomer or the third monomer if present; and each of the second consecutive block and the fourth consecutive block independently comprises one or more repeating units formed from the second monomer. In certain embodiments, the copolymer is a random copolymer. In certain embodiments, the step of polymerizing is substantially free of a chain transfer agent. In certain embodiments, the copolymer comprises one or more pharmaceutical agents, wherein the pharmaceutical agents are covalently attached to the copolymer. When the copolymer comprises one or more pharmaceutical agents, wherein the pharmaceutical agents are covalently attached to the copolymer, the copolymer, including the one or more pharmaceutical agents, may be referred to as a conjugate. The pharmaceutical agents include chemical compounds and mixtures of chemical compounds, e.g., small organic or inorganic molecules; saccharines; oligosaccharides; polysaccharides; biological macromolecules, e.g., peptides, proteins, and peptide analogs and derivatives; peptidomimetics; antibodies and antigen binding fragments thereof; nucleic acids; nucleic acid analogs and derivatives; an extract made from biological materials such as bacteria, plants, fungi, or animal cells; animal tissues; naturally occurring or synthetic compositions; and any combinations thereof. In certain embodiments, at least one of the pharmaceutical agents is a small molecule. In certain embodiments, at least one of the pharmaceutical agents is a protein or peptide. Exemplary pharmaceutical agents include, but are not limited to, those found in Harrison’s Principles of Internal Medicine , 13th Edition, Eds. T.R. Harrison et al. McGraw-Hill N.Y., NY; Physicians’ Desk Reference, 50th Edition, 1997, Oradell New Jersey, Medical Economics Co.; Pharmacological Basis of Therapeutics, 8th Edition, Goodman and Gilman, 1990; United States Pharmacopeia, The National Formulary, USP XII NF XVII, 1990; current edition of Goodman and Oilman’s The Pharmacological Basis of Therapeutics ; and current edition of The Merck Index , the complete contents of all of which are incorporated herein by reference. In certain embodiments, at least one of the pharmaceutical agents is a therapeutic agent. In certain embodiments, each instance of the pharmaceutical agent is a therapeutic agent. In some embodiments, exemplary therapeutic agents include, but are not limited to, one or more of the agents listed in Paragraph 0148 of U.S. Patent No.9,381,253, incorporated by reference herein. In other embodiments, exemplary therapeutic agents include, but are not limited to, one or more of the therapeutic agents listed in WO 2013/169739, including the anti-hypertensive and/or a collagen modifying agents (AHCM) disclosed, e.g., in Paragraphs 40-49, 283, 286-295; the microenviroment modulators disclosed, e.g., in Paragraphs 113-121, of WO 2013/169739, incorporated herein by reference. Examples of therapeutic agents also include, but are not limited to, antimicrobial agents, analgesics, antinflammatory agents, counterirritants, coagulation modifying agents, diuretics, sympathomimetics, anorexics, antacids and other gastrointestinal agents; antiparasitics, antidepressants, antihypertensives, anticholinergics, stimulants, antihormones, central and respiratory stimulants, drug antagonists, lipid-regulating agents, uricosurics, cardiac glycosides, electrolytes, ergot and derivatives thereof, expectorants, hypnotics and sedatives, antidiabetic agents, dopaminergic agents, antiemetics, muscle relaxants, para-sympathomimetics, anticonvulsants, antihistamines, beta-blockers, purgatives, antiarrhythmics, contrast materials, radiopharmaceuticals, antiallergic agents, tranquilizers, vasodilators, antiviral agents, and antineoplastic or cytostatic agents or other agents with anticancer properties, or a combination thereof. Other suitable therapeutic agents include contraceptives and vitamins as well as micro- and macronutrients. Still other examples include antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; anorexics; antiheimintics; antiarthritics; antiasthmatic agents; anticonvulsants; antidepressants; antidiuretic agents; antidiarrleals; antihistamines; antiinflammatory agents; antimigraine preparations; antinauseants; antineoplastics; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics, antispasmodics; anticholinergics; sympathomimetics; xanthine derivatives; cardiovascular preparations including calcium channel blockers and beta-blockers such as pindolol and antiarrhythmics; antihypertensives; diuretics; vasodilators including general coronary, peripheral and cerebral; central nervous system stimulants; cough and cold preparations, including decongestants; hormones such as estradiol and other steroids, including corticosteroids; hypnotics; immunosuppressives; muscle relaxants; parasympatholytics; psychostimulants; sedatives; and tranquilizers; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins. In certain embodiments, at least one of the pharmaceutical agents is an anti-cancer agent. Anti-cancer agents encompass biotherapeutic anti-cancer agents as well as chemotherapeutic agents. Exemplary biotherapeutic anti-cancer agents include, but are not limited to, interferons, cytokines (e.g., tumor necrosis factor, interferon α, interferon γ), vaccines, hematopoietic growth factors, monoclonal serotherapy, immunostimulants and/or immunodulatory agents (e.g., IL-1, 2, 4, 6, or 12), immune cell growth factors (e.g., GM-CSF) and antibodies (e.g., Herceptin (trastuzumab), T-DM1, AVASTIN (bevacizumab), ERBITUX (cetuximab), Vectibix (panitumumab), Rituxan (rituximab), Bexxar (tositumomab)). Exemplary chemotherapeutic agents include, but are not limited to, anti-estrogens (e.g., tamoxifen, raloxifene, and megestrol), LHRH agonists (e.g., goscrclin and leuprolide), anti-androgens (e.g., flutamide and bicalutamide), photodynamic therapies (e.g., vertoporfin (BPD-MA), phthalocyanine, photosensitizer Pc4, and demethoxy-hypocrellin A (2BA-2-DMHA)), nitrogen mustards (e.g., cyclophosphamide, ifosfamide, trofosfamide, chlorambucil, estramustine, and melphalan), nitrosoureas (e.g., carmustine (BCNU) and lomustine (CCNU)), alkylsulphonates (e.g., busulfan and treosulfan), triazenes (e.g., dacarbazine, temozolomide), platinum containing compounds (e.g., cisplatin, carboplatin, oxaliplatin), vinca alkaloids (e.g., vincristine, vinblastine, vindesine, and vinorelbine), taxoids (e.g., paclitaxel or a paclitaxel equivalent) docosahexaenoic acid bound-paclitaxel (DHA-paclitaxel, Taxoprexin), polyglutamate bound-paclitaxel (PG-paclitaxel, paclitaxel poliglumex, CT-2103, XYOTAX), the tumor-activated prodrug (TAP) ANG1005 (Angiopep-2 bound to three molecules of paclitaxel), paclitaxel-EC-1 (paclitaxel bound to the erbB2-recognizing peptide EC-1), and glucose-conjugated paclitaxel, e.g., 2'-paclitaxel methyl 2- glucopyranosyl succinate; docetaxel, taxol), epipodophyllins (e.g., etoposide, etoposide phosphate, teniposide, topotecan, 9-aminocamptothecin, camptoirinotecan, irinotecan, crisnatol, mytomycin C), anti-metabolites, DHFR inhibitors (e.g., methotrexate, dichloromethotrexate, trimetrexate, edatrexate), IMP dehydrogenase inhibitors (e.g., mycophenolic acid, tiazofurin, ribavirin, and EICAR), ribonuclotide reductase inhibitors (e.g., hydroxyurea and deferoxamine), uracil analogs (e.g., 5-fluorouracil (5-FU), floxuridine, doxifluridine, ratitrexed, tegafur-uracil, capecitabine), cytosine analogs (e.g., cytarabine (ara C), cytosine arabinoside, and fludarabine), purine analogs (e.g., mercaptopurine and Thioguanine), Vitamin D3 analogs (e.g., EB 1089, CB 1093, and KH 1060), isoprenylation inhibitors (e.g., lovastatin), dopaminergic neurotoxins (e.g., 1-methyl-4-phenylpyridinium ion), cell cycle inhibitors (e.g., staurosporine), actinomycin (e.g., actinomycin D, dactinomycin), bleomycin (e.g., bleomycin A2, bleomycin B2, peplomycin), anthracycline (e.g., daunorubicin, doxorubicin, pegylated liposomal doxorubicin, idarubicin, epirubicin, pirarubicin, zorubicin, mitoxantrone), MDR inhibitors (e.g., verapamil), Ca 2+ ATPase inhibitors (e.g., thapsigargin), imatinib, thalidomide, lenalidomide, tyrosine kinase inhibitors (e.g., axitinib (AG013736), bosutinib (SKI-606), cediranib (RECENTIN TM , AZD2171), dasatinib (SPRYCEL ® , BMS-354825), erlotinib (TARCEVA ® ), gefitinib (IRESSA ® ), imatinib (Gleevec ® , CGP57148B, STI-571), lapatinib (TYKERB ® , TYVERB ® ), lestaurtinib (CEP-701), neratinib (HKI-272), nilotinib (TASIGNA ® ), semaxanib (semaxinib, SU5416), sunitinib (SUTENT ® , SU11248), toceranib (PALLADIA ® ), vandetanib (ZACTIMA ® , ZD6474), vatalanib (PTK787, PTK/ZK), trastuzumab (HERCEPTIN ® ), bevacizumab (AVASTIN ® ), rituximab (RITUXAN ® ), cetuximab (ERBITUX ® ), panitumumab (VECTIBIX ® ), ranibizumab (Lucentis ® ), nilotinib (TASIGNA ® ), sorafenib (NEXAVAR ® ), everolimus (AFINITOR ® ), alemtuzumab (CAMPATH ® ), gemtuzumab ozogamicin (MYLOTARG ® ), temsirolimus (TORISEL ® ), ENMD- 2076, PCI-32765, AC220, dovitinib lactate (TKI258, CHIR-258), BIBW 2992 (TOVOK TM ), SGX523, PF-04217903, PF-02341066, PF-299804, BMS-777607, ABT-869, MP470, BIBF 1120 (VARGATEF ® ), AP24534, JNJ-26483327, MGCD265, DCC-2036, BMS-690154, CEP-11981, tivozanib (AV-951), OSI-930, MM-121, XL-184, XL-647, and/or XL228), proteasome inhibitors (e.g., bortezomib (Velcade)), mTOR inhibitors (e.g., rapamycin, temsirolimus (CCI-779), everolimus (RAD-001), ridaforolimus, AP23573 (Ariad), AZD8055 (AstraZeneca), BEZ235 (Novartis), BGT226 (Norvartis), XL765 (Sanofi Aventis), PF-4691502 (Pfizer), GDC0980 (Genetech), SF1126 (Semafoe), and OSI-027 (OSI)), oblimersen, gemcitabine, carminomycin, leucovorin, pemetrexed, cyclophosphamide, dacarbazine, procarbizine, prednisolone, dexamethasone, campathecin, plicamycin, asparaginase, aminopterin, methopterin, porfiromycin, melphalan, leurosidine, leurosine, chlorambucil, trabectedin, procarbazine, discodermolide, carminomycin, aminopterin, and hexamethyl melamine. In certain embodiments, the anti-cancer agent is JQ1, AZD5153, vincristine, abiraterone acetate (e.g., ZYTIGA), ABVD, ABVE, ABVE- PC, AC, AC-T, ADE, ado-trastuzumab emtansine (e.g., KADCYLA), afatinib dimaleate (e.g., GILOTRIF), aldesleukin (e.g., PROLEUKIN), alemtuzumab (e.g., CAMPATH), anastrozole (e.g., ARIMIDEX), arsenic trioxide (e.g., TRISENOX), asparaginase erwinia chrysanthemi (e.g., ERWINAZE), axitinib (e.g., INLYTA), azacitidine (e.g., MYLOSAR, VIDAZA), BEACOPP, belinostat (e.g., BELEODAQ), bendamustine hydrochloride (e.g., TREANDA), BEP, bevacizumab (e.g., AVASTIN), bicalutamide (e.g., CASODEX), bleomycin (e.g., BLENOXANE), blinatumomab (e.g., BLINCYTO), bortezomib (e.g., VELCADE), bosutinib (e.g., BOSULIF), brentuximab vedotin (e.g., ADCETRIS), busulfan (e.g., BUSULFEX, MYLERAN), cabazitaxel (e.g., JEVTANA), cabozantinib-s-malate (e.g., COMETRIQ), CAF, capecitabine (e.g., XELODA), CAPOX, carboplatin (e.g., PARAPLAT, PARAPLATIN), carboplatin-taxol, carfilzomib (e.g., KYPROLIS), carmustine (e.g., BECENUM, BICNU, CARMUBRIS), carmustine implant (e.g., GLIADEL WAFER, GLIADEL), ceritinib (e.g., ZYKADIA), cetuximab (e.g., ERBITUX), chlorambucil (e.g., AMBOCHLORIN, AMBOCLORIN, LEUKERAN, LINFOLIZIN), chlorambucil-prednisone, CHOP, cisplatin (e.g., PLATINOL, PLATINOL-AQ), clofarabine (e.g., CLOFAREX, CLOLAR), CMF, COPP, COPP- ABV, crizotinib (e.g., XALKORI), CVP, cyclophosphamide (e.g., CLAFEN, CYTOXAN, NEOSAR), cytarabine (e.g., CYTOSAR-U, TARABINE PFS), dabrafenib (e.g., TAFINLAR), dacarbazine (e.g., DTIC-DOME), dactinomycin (e.g., COSMEGEN), dasatinib (e.g., SPRYCEL), daunorubicin hydrochloride (e.g., CERUBIDINE), decitabine (e.g., DACOGEN), degarelix, denileukin diftitox (e.g., ONTAK), denosumab (e.g., PROLIA, XGEVA), Dinutuximab (e.g., UNITUXIN), docetaxel (e.g., TAXOTERE), doxorubicin hydrochloride (e.g., ADRIAMYCIN PFS, ADRIAMYCIN RDF), doxorubicin hydrochloride liposome (e.g., DOXIL, DOX-SL, EVACET, LIPODOX), enzalutamide (e.g., XTANDI), epirubicin hydrochloride (e.g., ELLENCE), EPOCH, erlotinib hydrochloride (e.g., TARCEVA), etoposide (e.g., TOPOSAR, VEPESID), etoposide phosphate (e.g., ETOPOPHOS), everolimus (e.g., AFINITOR DISPERZ, AFINITOR), exemestane (e.g., AROMASIN), FEC, fludarabine phosphate (e.g., FLUDARA), fluorouracil (e.g., ADRUCIL, EFUDEX, FLUOROPLEX), FOLFIRI , FOLFIRI- BEVACIZUMAB, FOLFIRI-CETUXIMAB, FOLFIRINOX, FOLFOX, FU-LV, fulvestrant (e.g., FASLODEX), gefitinib (e.g., IRESSA), gemcitabine hydrochloride (e.g., GEMZAR), gemcitabine-cisplatin, gemcitabine-oxaliplatin, goserelin acetate (e.g., ZOLADEX), Hyper- CVAD, ibritumomab tiuxetan (e.g., ZEVALIN), ibrutinib (e.g., IMBRUVICA), ICE, idelalisib (e.g., ZYDELIG), ifosfamide (e.g., CYFOS, IFEX, IFOSFAMIDUM), imatinib mesylate (e.g., GLEEVEC), imiquimod (e.g., ALDARA), ipilimumab (e.g., YERVOY), irinotecan hydrochloride (e.g., CAMPTOSAR), ixabepilone (e.g., IXEMPRA), lanreotide acetate (e.g., SOMATULINE DEPOT), lapatinib ditosylate (e.g., TYKERB), lenalidomide (e.g., REVLIMID), lenvatinib (e.g., LENVIMA), letrozole (e.g., FEMARA), leucovorin calcium (e.g., WELLCOVORIN), leuprolide acetate (e.g., LUPRON DEPOT, LUPRON DEPOT-3 MONTH, LUPRON DEPOT-4 MONTH, LUPRON DEPOT-PED, LUPRON, VIADUR), liposomal cytarabine (e.g., DEPOCYT), lomustine (e.g., CEENU), mechlorethamine hydrochloride (e.g., MUSTARGEN), megestrol acetate (e.g., MEGACE), mercaptopurine (e.g., PURINETHOL, PURIXAN), methotrexate (e.g., ABITREXATE, FOLEX PFS, FOLEX, METHOTREXATE LPF, MEXATE, MEXATE-AQ), mitomycin c (e.g., MITOZYTREX, MUTAMYCIN), mitoxantrone hydrochloride, MOPP, nelarabine (e.g., ARRANON), nilotinib (e.g., TASIGNA), nivolumab (e.g., OPDIVO), obinutuzumab (e.g., GAZYVA), OEPA, ofatumumab (e.g., ARZERRA), OFF, olaparib (e.g., LYNPARZA), omacetaxine mepesuccinate (e.g., SYNRIBO), OPPA, OTX-015, oxaliplatin (e.g., ELOXATIN), paclitaxel (e.g., TAXOL), paclitaxel albumin- stabilized nanoparticle formulation (e.g., ABRAXANE), PAD, palbociclib (e.g., IBRANCE), pamidronate disodium (e.g., AREDIA), panitumumab (e.g., VECTIBIX), panobinostat (e.g., FARYDAK), pazopanib hydrochloride (e.g., VOTRIENT), pegaspargase (e.g., ONCASPAR), peginterferon alfa-2b (e.g., PEG-INTRON), peginterferon alfa-2b (e.g., SYLATRON), pembrolizumab (e.g., KEYTRUDA), pemetrexed disodium (e.g., ALIMTA), pertuzumab (e.g., PERJETA), plerixafor (e.g., MOZOBIL), pomalidomide (e.g., POMALYST), ponatinib hydrochloride (e.g., ICLUSIG), pralatrexate (e.g., FOLOTYN), prednisone, procarbazine hydrochloride (e.g., MATULANE), radium 223 dichloride (e.g., XOFIGO), raloxifene hydrochloride (e.g., EVISTA, KEOXIFENE), ramucirumab (e.g., CYRAMZA), R-CHOP, recombinant HPV bivalent vaccine (e.g., CERVARIX), recombinant human papillomavirus (e.g., HPV) nonavalent vaccine (e.g., GARDASIL 9), recombinant human papillomavirus (e.g., HPV) quadrivalent vaccine (e.g., GARDASIL), recombinant interferon alfa-2b (e.g., INTRON A), regorafenib (e.g., STIVARGA), rituximab (e.g., RITUXAN), romidepsin (e.g., ISTODAX), ruxolitinib phosphate (e.g., JAKAFI), siltuximab (e.g., SYLVANT), sipuleucel-t (e.g., PROVENGE), sorafenib tosylate (e.g., NEXAVAR), STANFORD V, sunitinib malate (e.g., SUTENT), TAC, tamoxifen citrate (e.g., NOLVADEX, NOVALDEX), temozolomide (e.g., METHAZOLASTONE, TEMODAR), temsirolimus (e.g., TORISEL), thalidomide (e.g., SYNOVIR, THALOMID), thiotepa, topotecan hydrochloride (e.g., HYCAMTIN), toremifene (e.g., FARESTON), tositumomab and iodine I 131 tositumomab (e.g., BEXXAR), TPF, trametinib (e.g., MEKINIST), trastuzumab (e.g., HERCEPTIN), VAMP, vandetanib (e.g., CAPRELSA), VEIP, vemurafenib (e.g., ZELBORAF), vinblastine sulfate (e.g., VELBAN, VELSAR), vincristine sulfate (e.g., VINCASAR PFS), vincristine sulfate liposome (e.g., MARQIBO), vinorelbine tartrate (e.g., NAVELBINE), vismodegib (e.g., ERIVEDGE), vorinostat (e.g., ZOLINZA), XELIRI, XELOX, ziv-aflibercept (e.g., ZALTRAP), or zoledronic acid (e.g., ZOMETA), or a pharmaceutically acceptable salt thereof. In certain embodiments, at least one instance of the therapeutic agent is a bromodomain inhibitor. In certain embodiments, at least one instance of the therapeutic agent is a bromo and extra terminal protein (BET) inhibitor. In certain embodiments, at least one instance of the therapeutic agent is a bromodomain- containing protein 2 (BRD2) inhibitor, bromodomain-containing protein 3 (BRD3) inhibitor, bromodomain-containing protein 4 (BRD4) inhibitor, TBP (TATA box binding protein)- associated factor protein (TAF) (e.g., TAF1 or TAF1L) inhibitor, CREB-binding protein (CBP) inhibitor, or E1A binding protein p300 (EP300) inhibitor. In certain embodiments, at least one instance of the pharmaceutical agent is a PARP inhibitor, ALK inhibitor, or STING ligand. In certain embodiments, at least one of the pharmaceutical agents is a prophylactic agent. In certain embodiments, each instance of the pharmaceutical agent is a prophylactic agent. Prophylactic agents that can be included in the conjugates of the invention include, but are not limited to, antibiotics, nutritional supplements, and vaccines. Vaccines may comprise isolated proteins or peptides, inactivated organisms and viruses, dead organisms and viruses, genetically altered organisms or viruses, and cell extracts. Prophylactic agents may be combined with interleukins, interferon, cytokines, and adjuvants such as cholera toxin, alum, Freund's adjuvant. In certain embodiments, at least one of the pharmaceutical agents is a diagnostic agent. In certain embodiments, each instance of the pharmaceutical agent is a diagnostic agent. Exemplary diagnostic agents include, but are not limited to, fluorescent molecules; gases; metals; imaging agents, such as commercially available imaging agents used in positron emissions tomography (PET), computer assisted tomography (CAT), single photon emission computerized tomography, x-ray, fluoroscopy, and magnetic resonance imaging (MRI); and contrast agents. Examples of suitable materials for use as contrast agents in MRI include gadolinium chelates, as well as iron, magnesium, manganese, copper, and chromium. Examples of materials useful for CAT and x-ray imaging include iodine-based materials. In certain embodiments, the diagnostic agent is used in magnetic resonance imaging (MRI), such as iron oxide particles or gadolinium complexes. Gadolinium complexes that have been approved for clinical use include gadolinium chelates with DTPA, DTPA-BMA, DOTA and HP-DO3A which are reviewed in Aime, et al. (Chemical Society Reviews (1998), 27:19-29), the entire teachings of which are incorporated herein by reference. In certain embodiments, the diagnostic agent is a metal, inorganic compound, organometallic compound, organic compound, or salt thereof. In certain embodiments, the imaging agent contains a metal selected from the group consisting of scandium, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, niobium, molybdenum, technetium, ruthenium, rhodium, palladium, silver, cadmium, hafnium, tantalum, tungsten, rhenium, osmium, iridium, platinum, gold, mercury, rutherfordium, dubnium, seaborgium, bohrium, hassium, meitnerium, gadolinium, gallium, thallium, and barium. In certain embodiments, the diagnostic agent is an organic compound. In certain embodiments, the diagnostic agent is metal-free. In certain embodiments, the diagnostic agent is a metal-free organic compound. In certain embodiments, the imaging agent is a magnetic resonance imaging (MRI) agent. In certain embodiments, the MRI agent is gadolinium. In certain embodiments, the MRI agent is a nitroxide radical-containing compound. In certain embodiments, the imaging agent is a nuclear medicine imaging agent. In certain embodiments, the nuclear medicine imaging agent is selected from the group consisting of 64 Cu diacetyl-bis(N 4 -methylthiosemicarbazone) ( 64 Cu-ASTM), 18 F-fluorodeoxyglucose (FDG), 18 F- fluoride, 3'-deoxy-3'-[ 18 F]fluorothymidine (FLT), 18 F-fluoromisonidazole (FMISO), gallium, technetium-99m, and thallium. In certain embodiments, the imaging agent is radiographic imaging agent. In certain embodiments, the radiographic imaging agent is selected from the group consisting of barium, gastrografin, and iodine contrast agent. In certain embodiments, the imaging agent the diagnostic agent is a radical-containing compound. In certain embodiments, the imaging agent is a nitroxide radical-containing compound. In certain embodiments, the imaging agent the diagnostic agent is an organic compound. In certain embodiments, the imaging agent is a salt of an organic compound. In certain embodiments, the diagnostic agent may comprise a fluorescent molecule, a metal chelate, a contrast agent, a radionuclide, or a positron emission tomography (PET) imaging agent, an infrared imaging agent, a near-IR imaging agent, a computer assisted tomography (CAT) imaging agent, a photon emission computerized tomography imaging agent, an X-ray imaging agent, or a magnetic resonance imaging (MRI) agent. In some embodiments, the diagnostic agent is a fluorescent molecule. In some embodiments, the fluorescent molecule comprises an acridine dye, a cyanine dye, a rhodamine dye, a BODIPY dye, a fluorescein dye, a dansyl dye, an Alexa dye, an atto dye, a quantum dot, or a fluorescent protein. In some embodiments, the fluorescent molecule is a cyanine dye (e.g., Cy3, Cy 3.5, Cy5, Cy5.5, Cy7, or Cy7.5). In some embodiments, the diagnostic agent is an MRI agent (e.g., a contrast agent). Examples of suitable materials for use as MRI agents (e.g., contrast agents) include gadolinium chelates, as well as iron, magnesium, manganese, copper, and chromium. In some embodiments, the diagnostic agent is a CAT imaging agent or an X-ray imaging agent. Examples of materials useful for CAT and X-ray imaging include iodine-based materials. In some embodiments, the diagnostic agent is a PET imaging agent. Examples of suitable PET imaging agents include compounds and compositions comprising the positron emitting radioisotopoes 18 F, 15 O, 13 N, 11 C, 82 Rb, 64 Cu, and 68 Ga, e.g., fludeoxyglucose ( 18 F-FDG), 68 Ga- DOTA-psuedopeptides (e.g., 68 Ga-DOTA-TOC), 11 C-metomidate, 11 C-acetate, 11 C-methionine, 11 C-choline, 18 F-fluciclovine, 18 F-fluorocholine, 18 F-fluorodeoxysorbitol, 18 F-3’-fluoro-3’- deoxythymidine, 11 C-raclopride, and 18 F-desmethoxyfallypride. In some embodiments, the diagnostic agent is a near-IR imaging agent. Examples of near- IR imaging agents include Pz 247, DyLight 750, DyLight 800, cyanine dyes (e.g., Cy5, Cy5.5, Cy7), AlexaFluor 680, AlexaFluor 750, IRDye 680, IRDye 800CW, and Kodak X-SIGHT dyes. In some embodiments, the agent can be a radionuclide, e.g., for use as a therapeutic, diagnostic, or prognostic agents. Among the radionuclides used, gamma-emitters, positron- emitters, and X-ray emitters are suitable for diagnostic and/or therapy, while beta emitters and alpha-emitters may also be used for therapy. Suitable radionuclides for forming use with various embodiments of the present invention include, but are not limited to, 123 I, 125 I, 130 I, 131 I, 133 I, 135 I, 47 Sc, 72 As, 72 Sc, 90 Y, 88 Y, 97 Ru, 100 Pd, 101m Rh, 119 Sb, 128 Ba, 197 Hg, 211 At, 212 Bi, 212 Pb, 109 Pd, 111 In, 67 Ga, 68 Ga, 67 Cu, 75 Br, 77 Br, 99m Tc, 14 C, 13 N, 15 O, 32 P, 33 P, or 18 F. In certain embodiments, at least one instance of the diagnostic agent is a contrast agent. In certain embodiments, at least one instance of the contrast agent is a magnetic-resonance signal enhancing agent, X-ray attenuating agent, ultrasound scattering agent, or ultrasound frequency shifting agent. In certain embodiments, the pharmaceutical agent is a monovalent radical. In certain embodiments, the monovalent radical of the pharmaceutical agent is formed by removing a hydrogen atom from the moiety HV of the pharmaceutical agent. In certain embodiments, V is a carbon atom. In certain embodiments, V is a heteroatom. In certain embodiments, V is an oxygen atom. In certain embodiments, V is a sulfur atom. In certain embodiments, V is a nitrogen atom. In certain embodiments, the monovalent radical of the pharmaceutical agent is formed further by changing the atom V of the pharmaceutical agent to substituted or unsubstituted U, wherein each of V and U is a heteroatom, and V and U are different from each other. In another aspect, the present disclosure provides a composition comprising: the copolymer; and optionally an excipient. In certain embodiments, the composition is an adhesive composition. In certain embodiments, the composition is a coating composition. In certain embodiments, the composition comprises: the copolymer; and optionally a pharmaceutically acceptable excipient. In certain embodiments, the composition is a pharmaceutical composition. In certain embodiments, the pharmaceutical composition described herein comprises a copolymer described herein and a pharmaceutically acceptable excipient. In certain embodiments, the pharmaceutical composition described herein comprises a conjugate described herein and a pharmaceutically acceptable excipient. In certain embodiments, the pharmaceutical compositions are useful for delivering an agent (e.g., to a subject or cell). In certain embodiments, the pharmaceutical compositions are useful for treating a disease in a subject in need thereof. In certain embodiments, the pharmaceutical compositions are useful for preventing a disease in a subject. In certain embodiments, the copolymer or conjugate described herein is provided in an effective amount in the pharmaceutical composition. In certain embodiments, the effective amount is a therapeutically effective amount. In certain embodiments, the effective amount is a prophylactically effective amount. In certain embodiments, the effective amount is an amount effective for treating a proliferative disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a proliferative disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for treating a hematological disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a hematological disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for treating a neurological disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a neurological disease in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for treating a in a painful condition subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a painful condition in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for treating a psychiatric disorder in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a psychiatric disorder in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for treating a metabolic disorder in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for preventing a metabolic disorder in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for reducing the risk of developing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the effective amount is an amount effective for inhibiting the activity (e.g., aberrant activity, such as increased activity) of a protein kinase in a subject or cell. In certain embodiments, the cell is in vitro. In certain embodiments, the cell is in vivo. Pharmaceutical compositions described herein can be prepared by any method known in the art of pharmacology. In general, such preparatory methods include bringing the copolymer or conjugate described herein (which may includes a therapeutic agent (the “active ingredient”)) into association with a carrier or excipient, and/or one or more other accessory ingredients, and then, if necessary and/or desirable, shaping, and/or packaging the product into a desired single- or multi-dose unit. Pharmaceutical compositions can be prepared, packaged, and/or sold in bulk, as a single unit dose, and/or as a plurality of single unit doses. A “unit dose” is a discrete amount of the pharmaceutical composition comprising a predetermined amount of the active ingredient. The amount of the active ingredient is generally equal to the dosage of the active ingredient which would be administered to a subject and/or a convenient fraction of such a dosage, such as one- half or one-third of such a dosage. Relative amounts of the active ingredient, the pharmaceutically acceptable excipient, and/or any additional ingredients in a pharmaceutical composition described herein will vary, depending upon the identity, size, and/or condition of the subject treated and further depending upon the route by which the composition is to be administered. The composition may comprise between 0.1% and 100% (w/w) active ingredient. Pharmaceutically acceptable excipients used in the manufacture of provided pharmaceutical compositions include inert diluents, dispersing and/or granulating agents, surface active agents and/or emulsifiers, disintegrating agents, binding agents, preservatives, buffering agents, lubricating agents, and/or oils. Excipients such as cocoa butter and suppository waxes, coloring agents, coating agents, sweetening, flavoring, and perfuming agents may also be present in the composition. Exemplary diluents include calcium carbonate, sodium carbonate, calcium phosphate, dicalcium phosphate, calcium sulfate, calcium hydrogen phosphate, sodium phosphate lactose, sucrose, cellulose, microcrystalline cellulose, kaolin, mannitol, sorbitol, inositol, sodium chloride, dry starch, cornstarch, powdered sugar, and mixtures thereof. Exemplary granulating and/or dispersing agents include potato starch, corn starch, tapioca starch, sodium starch glycolate, clays, alginic acid, guar gum, citrus pulp, agar, bentonite, cellulose, and wood products, natural sponge, cation-exchange resins, calcium carbonate, silicates, sodium carbonate, cross-linked poly(vinyl-pyrrolidone) (crospovidone), sodium carboxymethyl starch (sodium starch glycolate), carboxymethyl cellulose, cross-linked sodium carboxymethyl cellulose (croscarmellose), methylcellulose, pregelatinized starch (starch 1500), microcrystalline starch, water insoluble starch, calcium carboxymethyl cellulose, magnesium aluminum silicate (Veegum), sodium lauryl sulfate, quaternary ammonium compounds, and mixtures thereof. Exemplary surface active agents and/or emulsifiers include natural emulsifiers (e.g., acacia, agar, alginic acid, sodium alginate, tragacanth, chondrux, cholesterol, xanthan, pectin, gelatin, egg yolk, casein, wool fat, cholesterol, wax, and lecithin), colloidal clays (e.g., bentonite (aluminum silicate) and Veegum (magnesium aluminum silicate)), long chain amino acid derivatives, high molecular weight alcohols (e.g., stearyl alcohol, cetyl alcohol, oleyl alcohol, triacetin monostearate, ethylene glycol distearate, glyceryl monostearate, and propylene glycol monostearate, polyvinyl alcohol), carbomers (e.g., carboxy polymethylene, polyacrylic acid, acrylic acid polymer, and carboxyvinyl polymer), carrageenan, cellulosic derivatives (e.g., carboxymethylcellulose sodium, powdered cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose), sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monolaurate (Tween ® 20), polyoxyethylene sorbitan monostearate (Tween ® 60), polyoxyethylene sorbitan monooleate (Tween ® 80), sorbitan monopalmitate (Span ® 40), sorbitan monostearate (Span ® 60), sorbitan tristearate (Span ® 65), glyceryl monooleate, sorbitan monooleate (Span ® 80), polyoxyethylene esters (e.g., polyoxyethylene monostearate (Myrj ® 45), polyoxyethylene hydrogenated castor oil, polyethoxylated castor oil, polyoxymethylene stearate, and Solutol ® ), sucrose fatty acid esters, polyethylene glycol fatty acid esters (e.g., Cremophor ® ), polyoxyethylene ethers, (e.g., polyoxyethylene lauryl ether (Brij ® 30)), poly(vinyl-pyrrolidone), diethylene glycol monolaurate, triethanolamine oleate, sodium oleate, potassium oleate, ethyl oleate, oleic acid, ethyl laurate, sodium lauryl sulfate, Pluronic ® F-68, poloxamer P-188, cetrimonium bromide, cetylpyridinium chloride, benzalkonium chloride, docusate sodium, and/or mixtures thereof. Exemplary binding agents include starch (e.g., cornstarch and starch paste), gelatin, sugars (e.g., sucrose, glucose, dextrose, dextrin, molasses, lactose, lactitol, mannitol, etc.), natural and synthetic gums (e.g., acacia, sodium alginate, extract of Irish moss, panwar gum, ghatti gum, mucilage of isapol husks, carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, cellulose acetate, poly(vinyl-pyrrolidone), magnesium aluminum silicate (Veegum ® ), and larch arabogalactan), alginates, polyethylene oxide, polyethylene glycol, inorganic calcium salts, silicic acid, polymethacrylates, waxes, water, alcohol, and/or mixtures thereof. Exemplary preservatives include antioxidants, chelating agents, antimicrobial preservatives, antifungal preservatives, antiprotozoan preservatives, alcohol preservatives, acidic preservatives, and other preservatives. In certain embodiments, the preservative is an antioxidant. In other embodiments, the preservative is a chelating agent. Exemplary antioxidants include alpha tocopherol, ascorbic acid, acorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, monothioglycerol, potassium metabisulfite, propionic acid, propyl gallate, sodium ascorbate, sodium bisulfite, sodium metabisulfite, and sodium sulfite. Exemplary chelating agents include ethylenediaminetetraacetic acid (EDTA) and salts and hydrates thereof (e.g., sodium edetate, disodium edetate, trisodium edetate, calcium disodium edetate, dipotassium edetate, and the like), citric acid and salts and hydrates thereof (e.g., citric acid monohydrate), fumaric acid and salts and hydrates thereof, malic acid and salts and hydrates thereof, phosphoric acid and salts and hydrates thereof, and tartaric acid and salts and hydrates thereof. Exemplary antimicrobial preservatives include benzalkonium chloride, benzethonium chloride, benzyl alcohol, bronopol, cetrimide, cetylpyridinium chloride, chlorhexidine, chlorobutanol, chlorocresol, chloroxylenol, cresol, ethyl alcohol, glycerin, hexetidine, imidurea, phenol, phenoxyethanol, phenylethyl alcohol, phenylmercuric nitrate, propylene glycol, and thimerosal. Exemplary antifungal preservatives include butyl paraben, methyl paraben, ethyl paraben, propyl paraben, benzoic acid, hydroxybenzoic acid, potassium benzoate, potassium sorbate, sodium benzoate, sodium propionate, and sorbic acid. Exemplary alcohol preservatives include ethanol, polyethylene glycol, phenol, phenolic compounds, bisphenol, chlorobutanol, hydroxybenzoate, and phenylethyl alcohol. Exemplary acidic preservatives include vitamin A, vitamin C, vitamin E, beta-carotene, citric acid, acetic acid, dehydroacetic acid, ascorbic acid, sorbic acid, and phytic acid. Other preservatives include tocopherol, tocopherol acetate, deteroxime mesylate, cetrimide, butylated hydroxyanisol (BHA), butylated hydroxytoluened (BHT), ethylenediamine, sodium lauryl sulfate (SLS), sodium lauryl ether sulfate (SLES), sodium bisulfite, sodium metabisulfite, potassium sulfite, potassium metabisulfite, Glydant ® Plus, Phenonip ® , methylparaben, Germall ® 115, Germaben ® II, Neolone ® , Kathon ® , and Euxyl ® . Exemplary buffering agents include citrate buffer solutions, acetate buffer solutions, phosphate buffer solutions, ammonium chloride, calcium carbonate, calcium chloride, calcium citrate, calcium glubionate, calcium gluceptate, calcium gluconate, D-gluconic acid, calcium glycerophosphate, calcium lactate, propanoic acid, calcium levulinate, pentanoic acid, dibasic calcium phosphate, phosphoric acid, tribasic calcium phosphate, calcium hydroxide phosphate, potassium acetate, potassium chloride, potassium gluconate, potassium mixtures, dibasic potassium phosphate, monobasic potassium phosphate, potassium phosphate mixtures, sodium acetate, sodium bicarbonate, sodium chloride, sodium citrate, sodium lactate, dibasic sodium phosphate, monobasic sodium phosphate, sodium phosphate mixtures, tromethamine, magnesium hydroxide, aluminum hydroxide, alginic acid, pyrogen-free water, isotonic saline, Ringer’s solution, ethyl alcohol, and mixtures thereof. Exemplary lubricating agents include magnesium stearate, calcium stearate, stearic acid, silica, talc, malt, glyceryl behanate, hydrogenated vegetable oils, polyethylene glycol, sodium benzoate, sodium acetate, sodium chloride, leucine, magnesium lauryl sulfate, sodium lauryl sulfate, and mixtures thereof. Exemplary natural oils include almond, apricot kernel, avocado, babassu, bergamot, black current seed, borage, cade, camomile, canola, caraway, carnauba, castor, cinnamon, cocoa butter, coconut, cod liver, coffee, corn, cotton seed, emu, eucalyptus, evening primrose, fish, flaxseed, geraniol, gourd, grape seed, hazel nut, hyssop, isopropyl myristate, jojoba, kukui nut, lavandin, lavender, lemon, litsea cubeba, macademia nut, mallow, mango seed, meadowfoam seed, mink, nutmeg, olive, orange, orange roughy, palm, palm kernel, peach kernel, peanut, poppy seed, pumpkin seed, rapeseed, rice bran, rosemary, safflower, sandalwood, sasquana, savoury, sea buckthorn, sesame, shea butter, silicone, soybean, sunflower, tea tree, thistle, tsubaki, vetiver, walnut, and wheat germ oils. Exemplary synthetic oils include butyl stearate, caprylic triglyceride, capric triglyceride, cyclomethicone, diethyl sebacate, dimethicone 360, isopropyl myristate, mineral oil, octyldodecanol, oleyl alcohol, silicone oil, and mixtures thereof. Liquid dosage forms for oral and parenteral administration include pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs. In addition to the active ingredients, the liquid dosage forms may comprise inert diluents commonly used in the art such as, for example, water or other solvents, solubilizing agents and emulsifiers such as ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butylene glycol, dimethylformamide, oils (e.g., cottonseed, groundnut, corn, germ, olive, castor, and sesame oils), glycerol, tetrahydrofurfuryl alcohol, polyethylene glycols and fatty acid esters of sorbitan, and mixtures thereof. Besides inert diluents, the oral compositions can include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, and perfuming agents. In certain embodiments for parenteral administration, the conjugates described herein are mixed with solubilizing agents such as Cremophor ® , alcohols, oils, modified oils, glycols, polysorbates, cyclodextrins, polymers, and mixtures thereof. Injectable preparations, for example, sterile injectable aqueous or oleaginous suspensions can be formulated according to the known art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation can be a sterile injectable solution, suspension, or emulsion in a nontoxic parenterally acceptable diluent or solvent, for example, as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that can be employed are water, Ringer’s solution, U.S.P., and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil can be employed including synthetic mono- or di-glycerides. In addition, fatty acids such as oleic acid are used in the preparation of injectables. The injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter, or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable medium prior to use. In order to prolong the effect of a drug, it is often desirable to slow the absorption of the drug from subcutaneous or intramuscular injection. This can be accomplished by the use of a liquid suspension of crystalline or amorphous material with poor water solubility. The rate of absorption of the drug then depends upon its rate of dissolution, which, in turn, may depend upon crystal size and crystalline form. Alternatively, delayed absorption of a parenterally administered drug form may be accomplished by dissolving or suspending the drug in an oil vehicle. Compositions for rectal or vaginal administration are typically suppositories which can be prepared by mixing the conjugates described herein with suitable non-irritating excipients or carriers such as cocoa butter, polyethylene glycol, or a suppository wax which are solid at ambient temperature but liquid at body temperature and therefore melt in the rectum or vaginal cavity and release the active ingredient. Solid dosage forms for oral administration include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active ingredient is mixed with at least one inert, pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or (a) fillers or extenders such as starches, lactose, sucrose, glucose, mannitol, and silicic acid, (b) binders such as, for example, carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidinone, sucrose, and acacia, (c) humectants such as glycerol, (d) disintegrating agents such as agar, calcium carbonate, potato or tapioca starch, alginic acid, certain silicates, and sodium carbonate, (e) solution retarding agents such as paraffin, (f) absorption accelerators such as quaternary ammonium compounds, (g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, (h) absorbents such as kaolin and bentonite clay, and (i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets, and pills, the dosage form may include a buffering agent. Solid compositions of a similar type can be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polyethylene glycols and the like. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings and other coatings well known in the art of pharmacology. They may optionally comprise opacifying agents and can be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of encapsulating compositions which can be used include polymeric substances and waxes. Solid compositions of a similar type can be employed as fillers in soft and hard-filled gelatin capsules using such excipients as lactose or milk sugar as well as high molecular weight polethylene glycols and the like. The active ingredient can be in a micro-encapsulated form with one or more excipients as noted above. The solid dosage forms of tablets, dragees, capsules, pills, and granules can be prepared with coatings and shells such as enteric coatings, release controlling coatings, and other coatings well known in the pharmaceutical formulating art. In such solid dosage forms the active ingredient can be admixed with at least one inert diluent such as sucrose, lactose, or starch. Such dosage forms may comprise, as is normal practice, additional substances other than inert diluents, e.g., tableting lubricants and other tableting aids such a magnesium stearate and microcrystalline cellulose. In the case of capsules, tablets and pills, the dosage forms may comprise buffering agents. They may optionally comprise opacifying agents and can be of a composition that they release the active ingredient(s) only, or preferentially, in a certain part of the intestinal tract, optionally, in a delayed manner. Examples of encapsulating agents which can be used include polymeric substances and waxes. Dosage forms for topical and/or transdermal administration of a copolymer or conjugate described herein may include ointments, pastes, creams, lotions, gels, powders, solutions, sprays, inhalants, and/or patches. Generally, the active ingredient is admixed under sterile conditions with a pharmaceutically acceptable carrier or excipient and/or any needed preservatives and/or buffers as can be required. Additionally, the present disclosure contemplates the use of transdermal patches, which often have the added advantage of providing controlled delivery of an active ingredient to the body. Such dosage forms can be prepared, for example, by dissolving and/or dispensing the active ingredient in the proper medium. Alternatively or additionally, the rate can be controlled by either providing a rate controlling membrane and/or by dispersing the active ingredient in a polymer matrix and/or gel. Suitable devices for use in delivering intradermal pharmaceutical compositions described herein include short needle devices. Intradermal compositions can be administered by devices which limit the effective penetration length of a needle into the skin. Alternatively or additionally, conventional syringes can be used in the classical mantoux method of intradermal administration. Jet injection devices which deliver liquid formulations to the dermis via a liquid jet injector and/or via a needle which pierces the stratum corneum and produces a jet which reaches the dermis are suitable. Ballistic powder/particle delivery devices which use compressed gas to accelerate the copolymer or conjugate in powder form through the outer layers of the skin to the dermis are suitable. Formulations suitable for topical administration include liquid and/or semi-liquid preparations such as liniments, lotions, oil-in-water and/or water-in-oil emulsions such as creams, ointments, and/or pastes, and/or solutions and/or suspensions. Topically administrable formulations may, for example, comprise from about 1% to about 10% (w/w) active ingredient, although the concentration of the active ingredient can be as high as the solubility limit of the active ingredient in the solvent. Formulations for topical administration may further comprise one or more of the additional ingredients described herein. A pharmaceutical composition described herein can be prepared, packaged, and/or sold in a formulation suitable for pulmonary administration via the buccal cavity. Such a formulation may comprise dry particles which comprise the active ingredient and which have a diameter in the range from about 0.5 to about 7 nanometers, or from about 1 to about 6 nanometers. Such compositions are conveniently in the form of dry powders for administration using a device comprising a dry powder reservoir to which a stream of propellant can be directed to disperse the powder and/or using a self-propelling solvent/powder dispensing container such as a device comprising the active ingredient dissolved and/or suspended in a low-boiling propellant in a sealed container. Such powders comprise particles wherein at least 98% of the particles by weight have a diameter greater than 0.5 nanometers and at least 95% of the particles by number have a diameter less than 7 nanometers. Alternatively, at least 95% of the particles by weight have a diameter greater than 1 nanometer and at least 90% of the particles by number have a diameter less than 6 nanometers. Dry powder compositions may include a solid fine powder diluent such as sugar and are conveniently provided in a unit dose form. Low boiling propellants generally include liquid propellants having a boiling point of below 65 °F at atmospheric pressure. Generally the propellant may constitute 50 to 99.9% (w/w) of the composition, and the active ingredient may constitute 0.1 to 20% (w/w) of the composition. The propellant may further comprise additional ingredients such as a liquid non- ionic and/or solid anionic surfactant and/or a solid diluent (which may have a particle size of the same order as particles comprising the active ingredient). Pharmaceutical compositions described herein formulated for pulmonary delivery may provide the active ingredient in the form of droplets of a solution and/or suspension. Such formulations can be prepared, packaged, and/or sold as aqueous and/or dilute alcoholic solutions and/or suspensions, optionally sterile, comprising the active ingredient, and may conveniently be administered using any nebulization and/or atomization device. Such formulations may further comprise one or more additional ingredients including a flavoring agent such as saccharin sodium, a volatile oil, a buffering agent, a surface active agent, and/or a preservative such as methylhydroxybenzoate. The droplets provided by this route of administration may have an average diameter in the range from about 0.1 to about 200 nanometers. Formulations described herein as being useful for pulmonary delivery are useful for intranasal delivery of a pharmaceutical composition described herein. Another formulation suitable for intranasal administration is a coarse powder comprising the active ingredient and having an average particle from about 0.2 to 500 micrometers. Such a formulation is administered by rapid inhalation through the nasal passage from a container of the powder held close to the nares. Formulations for nasal administration may, for example, comprise from about as little as 0.1% (w/w) to as much as 100% (w/w) of the active ingredient, and may comprise one or more of the additional ingredients described herein. A pharmaceutical composition described herein can be prepared, packaged, and/or sold in a formulation for buccal administration. Such formulations may, for example, be in the form of tablets and/or lozenges made using conventional methods, and may contain, for example, 0.1 to 20% (w/w) active ingredient, the balance comprising an orally dissolvable and/or degradable composition and, optionally, one or more of the additional ingredients described herein. Alternately, formulations for buccal administration may comprise a powder and/or an aerosolized and/or atomized solution and/or suspension comprising the active ingredient. Such powdered, aerosolized, and/or aerosolized formulations, when dispersed, may have an average particle and/or droplet size in the range from about 0.1 to about 200 nanometers, and may further comprise one or more of the additional ingredients described herein. A pharmaceutical composition described herein can be prepared, packaged, and/or sold in a formulation for ophthalmic administration. Such formulations may, for example, be in the form of eye drops including, for example, a 0.1-1.0% (w/w) solution and/or suspension of the active ingredient in an aqueous or oily liquid carrier or excipient. Such drops may further comprise buffering agents, salts, and/or one or more other of the additional ingredients described herein. Other opthalmically-administrable formulations which are useful include those which comprise the active ingredient in microcrystalline form and/or in a liposomal preparation. Ear drops and/or eye drops are also contemplated as being within the scope of this disclosure. Although the descriptions of pharmaceutical compositions provided herein are principally directed to pharmaceutical compositions which are suitable for administration to humans, it will be understood by the skilled artisan that such compositions are generally suitable for administration to animals of all sorts. Modification of pharmaceutical compositions suitable for administration to humans in order to render the compositions suitable for administration to various animals is well understood, and the ordinarily skilled veterinary pharmacologist can design and/or perform such modification with ordinary experimentation. Copolymers provided herein are typically formulated in dosage unit form for ease of administration and uniformity of dosage. It will be understood, however, that the total daily usage of the compositions described herein will be decided by a physician within the scope of sound medical judgment. The specific therapeutically effective dose level for any particular subject or organism will depend upon a variety of factors including the disease being treated and the severity of the disorder; the activity of the specific active ingredient employed; the specific composition employed; the age, body weight, general health, sex, and diet of the subject; the time of administration, route of administration, and rate of excretion of the specific active ingredient employed; the duration of the treatment; drugs used in combination or coincidental with the specific active ingredient employed; and like factors well known in the medical arts. The copolymers, conjugates, and compositions provided herein can be administered by any route, including enteral (e.g., oral), parenteral, intravenous, intramuscular, intra-arterial, intramedullary, intrathecal, subcutaneous, intraventricular, transdermal, interdermal, rectal, intravaginal, intraperitoneal, topical (as by powders, ointments, creams, and/or drops), mucosal, nasal, bucal, sublingual; by intratracheal instillation, bronchial instillation, and/or inhalation; and/or as an oral spray, nasal spray, and/or aerosol. Specifically contemplated routes are oral administration, intravenous administration (e.g., systemic intravenous injection), regional administration via blood and/or lymph supply, and/or direct administration to an affected site. In general, the most appropriate route of administration will depend upon a variety of factors including the nature of the agent (e.g., its stability in the environment of the gastrointestinal tract), and/or the condition of the subject (e.g., whether the subject is able to tolerate oral administration). In certain embodiments, the copolymer, conjugate, or pharmaceutical composition described herein is suitable for topical administration to the eye of a subject. The exact amount of a copolymer or conjugate required to achieve an effective amount will vary from subject to subject, depending, for example, on species, age, and general condition of a subject, severity of the side effects or disorder, identity of the particular copolymer or conjugate, mode of administration, and the like. An effective amount may be included in a single dose (e.g., single oral dose) or multiple doses (e.g., multiple oral doses). In certain embodiments, when multiple doses are administered to a subject or applied to a tissue or cell, any two doses of the multiple doses include different or substantially the same amounts of a copolymer or conjugate described herein. In certain embodiments, when multiple doses are administered to a subject or applied to a tissue or cell, the frequency of administering the multiple doses to the subject or applying the multiple doses to the tissue or cell is three doses a day, two doses a day, one dose a day, one dose every other day, one dose every third day, one dose every week, one dose every two weeks, one dose every three weeks, or one dose every four weeks. In certain embodiments, the frequency of administering the multiple doses to the subject or applying the multiple doses to the tissue or cell is one dose per day. In certain embodiments, the frequency of administering the multiple doses to the subject or applying the multiple doses to the tissue or cell is two doses per day. In certain embodiments, the frequency of administering the multiple doses to the subject or applying the multiple doses to the tissue or cell is three doses per day. In certain embodiments, when multiple doses are administered to a subject or applied to a tissue or cell, the duration between the first dose and last dose of the multiple doses is one day, two days, four days, one week, two weeks, three weeks, one month, two months, three months, four months, six months, nine months, one year, two years, three years, four years, five years, seven years, ten years, fifteen years, twenty years, or the lifetime of the subject, tissue, or cell. In certain embodiments, the duration between the first dose and last dose of the multiple doses is three months, six months, or one year. In certain embodiments, the duration between the first dose and last dose of the multiple doses is the lifetime of the subject, tissue, or cell. In certain embodiments, a dose (e.g., a single dose, or any dose of multiple doses) described herein includes independently between 0.1 µg and 1 µg, between 0.001 mg and 0.01 mg, between 0.01 mg and 0.1 mg, between 0.1 mg and 1 mg, between 1 mg and 3 mg, between 3 mg and 10 mg, between 10 mg and 30 mg, between 30 mg and 100 mg, between 100 mg and 300 mg, between 300 mg and 1,000 mg, or between 1 g and 10 g, inclusive, of a copolymer or conjugate described herein. In certain embodiments, a dose described herein includes independently between 1 mg and 3 mg, inclusive, of a copolymer or conjugate described herein. In certain embodiments, a dose described herein includes independently between 3 mg and 10 mg, inclusive, of a copolymer or conjugate described herein. In certain embodiments, a dose described herein includes independently between 10 mg and 30 mg, inclusive, of a copolymer or conjugate described herein. In certain embodiments, a dose described herein includes independently between 30 mg and 100 mg, inclusive, of a copolymer or conjugate described herein. Dose ranges as described herein provide guidance for the administration of provided pharmaceutical compositions to an adult. The amount to be administered to, for example, a child or an adolescent can be determined by a medical practitioner or person skilled in the art and can be lower or the same as that administered to an adult. In certain embodiments, a dose described herein is a dose to an adult human whose body weight is 70 kg. A copolymer, conjugate, or composition, as described herein, can be administered in combination with one or more additional pharmaceutical agents (e.g., therapeutically and/or prophylactically active agents). The copolymers, conjugates, or compositions can be administered in combination with additional pharmaceutical agents that improve their activity (e.g., activity (e.g., potency and/or efficacy) in treating a disease in a subject in need thereof, in preventing a disease in a subject in need thereof, in reducing the risk to develop a disease in a subject in need thereof, and/or in inhibiting the activity of a protein kinase in a subject or cell), improve bioavailability, improve safety, reduce drug resistance, reduce and/or modify metabolism, inhibit excretion, and/or modify distribution in a subject or cell. It will also be appreciated that the therapy employed may achieve a desired effect for the same disorder, and/or it may achieve different effects. In certain embodiments, a pharmaceutical composition described herein including a copolymer or conjugate described herein and an additional pharmaceutical agent shows a synergistic effect that is absent in a pharmaceutical composition including one of the copolymer/conjugate and the additional pharmaceutical agent, but not both. The copolymer, conjugate, or composition can be administered concurrently with, prior to, or subsequent to one or more additional pharmaceutical agents, which are different from the copolymer, conjugate, or composition and may be useful as, e.g., combination therapies. Pharmaceutical agents include therapeutically active agents. Pharmaceutical agents also include prophylactically active agents. Pharmaceutical agents include small organic molecules such as drug compounds (e.g., compounds approved for human or veterinary use by the U.S. Food and Drug Administration as provided in the Code of Federal Regulations (CFR)), peptides, proteins, carbohydrates, monosaccharides, oligosaccharides, polysaccharides, nucleoproteins, mucoproteins, lipoproteins, synthetic polypeptides or proteins, small molecules linked to proteins, glycoproteins, steroids, nucleic acids, DNAs, RNAs, nucleotides, nucleosides, oligonucleotides, antisense oligonucleotides, lipids, hormones, vitamins, and cells. In certain embodiments, the additional pharmaceutical agent is a pharmaceutical agent useful for treating and/or preventing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder). Each additional pharmaceutical agent may be administered at a dose and/or on a time schedule determined for that pharmaceutical agent. The additional pharmaceutical agents may also be administered together with each other and/or with the copolymer, conjugate, or composition described herein in a single dose or administered separately in different doses. The particular combination to employ in a regimen will take into account compatibility of the copolymer or conjugate described herein with the additional pharmaceutical agent(s) and/or the desired therapeutic and/or prophylactic effect to be achieved. In general, it is expected that the additional pharmaceutical agent(s) in combination be utilized at levels that do not exceed the levels at which they are utilized individually. In some embodiments, the levels utilized in combination will be lower than those utilized individually. The additional pharmaceutical agents include anti-proliferative agents, anti-cancer agents, cytotoxic agents, anti-angiogenesis agents, anti-inflammatory agents, immunosuppressants, anti- bacterial agents, anti-viral agents, cardiovascular agents, cholesterol-lowering agents, anti- diabetic agents, anti-allergic agents, contraceptive agents, and pain-relieving agents. In certain embodiments, the additional pharmaceutical agent is an anti-proliferative agent. In certain embodiments, the additional pharmaceutical agent is an anti-cancer agent. In certain embodiments, the additional pharmaceutical agent is an anti-viral agent. In certain embodiments, the additional pharmaceutical agent is a binder or inhibitor of a protein kinase. In certain embodiments, the additional pharmaceutical agent is selected from the group consisting of epigenetic or transcriptional modulators (e.g., DNA methyltransferase inhibitors, histone deacetylase inhibitors (HDAC inhibitors), lysine methyltransferase inhibitors), antimitotic drugs (e.g., taxanes and vinca alkaloids), hormone receptor modulators (e.g., estrogen receptor modulators and androgen receptor modulators), cell signaling pathway inhibitors (e.g., tyrosine protein kinase inhibitors), modulators of protein stability (e.g., proteasome inhibitors), Hsp90 inhibitors, glucocorticoids, all-trans retinoic acids, and other agents that promote differentiation. In certain embodiments, the copolymers or conjugates described herein or pharmaceutical compositions can be administered in combination with an anti-cancer therapy including surgery, radiation therapy, transplantation (e.g., stem cell transplantation, bone marrow transplantation), immunotherapy, and chemotherapy. In another aspect, the present disclosure provides a kit comprising: the copolymer; and instructions for using the copolymer. In certain embodiments, the kits are useful for delivering a pharmaceutical agent (e.g., to a subject or cell). In certain embodiments, the kits are useful for treating a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits are useful for preventing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits are useful for reducing the risk of developing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits are useful for inhibiting the activity (e.g., aberrant activity, such as increased activity) of a protein kinase in a subject or cell. In certain embodiments, a kit described herein further includes instructions for using the kit. A kit described herein may also include information as required by a regulatory agency such as the U.S. Food and Drug Administration (FDA). In certain embodiments, the information included in the kits is prescribing information. In certain embodiments, the kits and instructions provide for delivering a pharmaceutical agent. In certain embodiments, the kits and instructions provide for treating a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits and instructions provide for preventing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits and instructions provide for reducing the risk of developing a disease (e.g., proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. In certain embodiments, the kits and instructions provide for inhibiting the activity (e.g., aberrant activity, such as increased activity) of a protein kinase in a subject or cell. A kit described herein may include one or more additional pharmaceutical agents described herein as a separate composition. In another aspect, the present disclosure provides a method of delivering a pharmaceutical agent to a subject in need thereof comprising administering to the subject in need thereof an effective amount of the copolymer. In another aspect, the present disclosure provides a method of treating a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer. In another aspect, the present disclosure provides a method of preventing a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer. In another aspect, the present disclosure provides a method of diagnosing a disease in a subject in need thereof comprising administering to or implanting in the subject in need thereof an effective amount of the copolymer. In certain embodiments, the disease is a proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder. In certain embodiments, the disease is a cancer. In certain embodiments, the disease is a solid tumor. In certain embodiments, the disease is a hematologic malignancy. In certain embodiments, lung cancer, large bowel cancer, pancreas cancer, biliary tract cancer, or endometrial cancer. In certain embodiments, the disease is benign neoplasm, angiogenesis, inflammatory disease, autoinflammatory disease, or autoimmune disease. In certain embodiments, the copolymers are useful for the treatment or prevention of the disease in part because at least one instance of the pharmaceutical agents included in the copolymers are useful for the treatment or prevention of the disease. For example, when the disease is cancer, at least one of the pharmaceutical agents is an anti-cancer agent. In certain embodiments, the copolymers are advantageous over the at least one instance of the pharmaceutical agents for the treatment or prevention of the disease in part because the copolymers improve (e.g., increase) the delivery of the at least one instance of the pharmaceutical agents to the subject (e.g., to the target organ, tissue, or cell of the subject). In certain embodiments, the copolymers are useful for diagnosing the disease in part because at least one instance of the pharmaceutical agents included in the copolymers are useful for diagnosing the disease. In certain embodiments, the copolymers are advantageous over the at least one instance of the pharmaceutical agents for diagnosing the disease in part because the copolymers improve (e.g., increase) the delivery of the at least one instance of the pharmaceutical agents to the subject (e.g., to the target organ, tissue, or cell of the subject). In certain embodiments, the subject is a human. In certain embodiments, the subject is a human aged 18 years or above. In some embodiments, the subject is a human aged <2 years. In some embodiments, the subject is a human aged 2-6 years, inclusive. In some embodiments, the subject is a human aged 6-18 years, inclusive. EXAMPLES In order that the present disclosure may be more fully understood, the following examples are set forth. The synthetic and biological examples described in this application are offered to illustrate the compounds, pharmaceutical compositions, and methods provided herein and are not to be construed in any way as limiting their scope. Example 1. In the small molecule form, a silyl ether containing an internal pentafluorophenyl (Si- PFP) was cleaved when exposed to a nucleophile (such as a thiol) in the presence of base (such as Cs 2 CO 3 ). Following reaction, gas chromatography-mass spectrometry (GC-MS) showed a disappearance of the Si-PFP and appearance of decomposition/cleavage product cis-butenediol. See Figure 3. Example 2. Degradation in pDCPD thermoset materials A control gel and a Nb-PFP-doped gel were prepared as described in Figures 4A and 4B. For degradation studies, THF was used as the solvent over N,N-dimethylformamide (DMF), as THF was better at swelling the gels, thus allowing the reagents access to the PFP sites. DBU was used as the base. Para-fluoro-thiol reaction (PFTR) has been shown to occur in THF with DBU (Cavalli et al., Chemistry – A European Journal, 2019, 25, 10049-10053). The samples were subjected to the degradation conditions shown in Figures 4A and 4B. After 3 h, the control gel showed degradation in only TBAF, leaving behind a thin skin layer of low mass, consistent with iPrSi-doped thermoset materials (Figure 4A). The Nb-PFP- doped gel, however, showed degradation in TBAF, and also in the presence of 1-dodecanethiol and DBU, but not in the presence of 1-dodecanethiol alone or DBU alone (Figure 4B). EQUIVALENTS AND SCOPE In the claims articles such as “a,” “an,” and “the” may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include “or” between one or more members of a group are considered satisfied if one, more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process unless indicated to the contrary or otherwise evident from the context. The invention includes embodiments in which exactly one member of the group is present in, employed in, or otherwise relevant to a given product or process. The invention includes embodiments in which more than one, or all of the group members are present in, employed in, or otherwise relevant to a given product or process. Furthermore, the invention encompasses all variations, combinations, and permutations in which one or more limitations, elements, clauses, and descriptive terms from one or more of the listed claims is introduced into another claim. For example, any claim that is dependent on another claim can be modified to include one or more limitations found in any other claim that is dependent on the same base claim. Where elements are presented as lists, e.g., in Markush group format, each subgroup of the elements is also disclosed, and any element(s) can be removed from the group. It should it be understood that, in general, where the invention, or aspects of the invention, is/are referred to as comprising particular elements and/or features, certain embodiments of the invention or aspects of the invention consist, or consist essentially of, such elements and/or features. For purposes of simplicity, those embodiments have not been specifically set forth in haec verba herein. It is also noted that the terms “comprising” and “containing” are intended to be open and permits the inclusion of additional elements or steps. Where ranges are given, endpoints are included. Furthermore, unless otherwise indicated or otherwise evident from the context and understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value or sub-range within the stated ranges in different embodiments of the invention, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise. This application refers to various issued patents, published patent applications, journal articles, and other publications, all of which are incorporated herein by reference. The entire contents of U.S. Patent Application Publication Number US-2020-0055879; U.S. Provisional Patent Application Numbers 63/144437 and 63/111608; and international PCT Application Number PCT/US2020/050927 are incorporated herein by reference. If there is a conflict between any of the incorporated references and the instant specification, the specification shall control. In addition, any particular embodiment of the present invention that falls within the prior art may be explicitly excluded from any one or more of the claims. Because such embodiments are deemed to be known to one of ordinary skill in the art, they may be excluded even if the exclusion is not set forth explicitly herein. Any particular embodiment of the invention can be excluded from any claim, for any reason, whether or not related to the existence of prior art. Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation many equivalents to the specific embodiments described herein. The scope of the present embodiments described herein is not intended to be limited to the above Description, but rather is as set forth in the appended claims. Those of ordinary skill in the art will appreciate that various changes and modifications to this description may be made without departing from the spirit or scope of the present invention, as defined in the following claims.
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