Title:
LATERAL FLOW DEVICE FOR DETECTION OF NEUTRALIZING ANTIBODIES AGAINST SARS-COV-2
Document Type and Number:
WIPO Patent Application WO/2021/217032
Kind Code:
A3
Abstract:
The present disclosure provides a lateral flow device, and methods of use of the device, for accurately and rapidly detecting a COVID-19 infection in a subject. The lateral flow device described herein detects in a liquid sample from the subject the presence or absence of neutralizing and non-neutralizing anti-S1 spike antibodies as IgM and IgG types. The anti-S1 antibodies neutralizing antibodies (e.g., both IgM and IgG) can block binding between ACE2 antigen and S1 spike protein which is the basis for the design of the lateral flow device.
Inventors:
JI HENRY HONGJUN (US)
Application Number:
PCT/US2021/028892
Publication Date:
December 16, 2021
Filing Date:
April 23, 2021
Export Citation:
Assignee:
SORRENTO THERAPEUTICS INC (US)
International Classes:
G01N33/543; G01N33/569; G01N33/68
Other References:
TAN CHEE WAH ET AL: "A SARS-CoV-2 surrogate virus neutralization test (sVNT) based on antibody-mediated blockage of ACE2-spike (RBD) protein-protein interaction", RESEARCH SQUARE, 23 April 2020 (2020-04-23), pages 1 - 15, XP055781210, Retrieved from the Internet [retrieved on 20210302], DOI: 10.21203/rs.3.rs-24574/v1
ZHENGTU LI ET AL: "Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis", JOURNAL OF MEDICAL VIROLOGY, vol. 92, no. 9, 13 April 2020 (2020-04-13), US, pages 1518 - 1524, XP055737277, ISSN: 0146-6615, DOI: 10.1002/jmv.25727
"Paper Based Sensors", vol. 89, 1 January 2020, ELSEVIER, NL, ISBN: 978-0-444-64345-2, ISSN: 0166-526X, article CALUCHO ENRIC ET AL: "Chapter 10: Nanoparticle-based lateral flow assays", pages: 313 - 359, XP055783265, DOI: 10.1016/bs.coac.2020.04.011
ZHANG NAN ET AL: "A lateral flow test detecting SARS-CoV-2 neutralizing antibodies", MEDRXIV, 10 November 2020 (2020-11-10), XP055809214, Retrieved from the Internet [retrieved on 20210531], DOI: 10.1101/2020.11.05.20222596
LAKE DOUGLAS F. ET AL: "Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2", MEDRXIV, 16 December 2020 (2020-12-16), XP055809181, Retrieved from the Internet [retrieved on 20210531], DOI: 10.1101/2020.12.15.20248264
FULFORD THOMAS S. ET AL: "A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2", MEDRXIV, 19 April 2021 (2021-04-19), pages 1 - 24, XP055834632, Retrieved from the Internet [retrieved on 20210824], DOI: 10.1101/2021.04.12.21255368
ZHENGTU LI ET AL: "Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis", JOURNAL OF MEDICAL VIROLOGY, vol. 92, no. 9, 13 April 2020 (2020-04-13), US, pages 1518 - 1524, XP055737277, ISSN: 0146-6615, DOI: 10.1002/jmv.25727
"Paper Based Sensors", vol. 89, 1 January 2020, ELSEVIER, NL, ISBN: 978-0-444-64345-2, ISSN: 0166-526X, article CALUCHO ENRIC ET AL: "Chapter 10: Nanoparticle-based lateral flow assays", pages: 313 - 359, XP055783265, DOI: 10.1016/bs.coac.2020.04.011
ZHANG NAN ET AL: "A lateral flow test detecting SARS-CoV-2 neutralizing antibodies", MEDRXIV, 10 November 2020 (2020-11-10), XP055809214, Retrieved from the Internet
LAKE DOUGLAS F. ET AL: "Development of a Rapid Point-Of-Care Test that Measures Neutralizing Antibodies to SARS-CoV-2", MEDRXIV, 16 December 2020 (2020-12-16), XP055809181, Retrieved from the Internet
FULFORD THOMAS S. ET AL: "A point-of-care lateral flow assay for neutralising antibodies against SARS-CoV-2", MEDRXIV, 19 April 2021 (2021-04-19), pages 1 - 24, XP055834632, Retrieved from the Internet
Attorney, Agent or Firm:
BREIER, Adam M. et al. (US)
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