Title:
LAYERED CELL SHEET INCORPORATING HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2014/192909
Kind Code:
A1
Abstract:
The present invention pertains to a layered cell sheet containing living cells and a method for producing the same. Specifically, the present invention provides: a method for layering a cell sheet including a step for layering a cell sheet using a hydrogel, preferably a gelatin hydrogel; a layered cell sheet produced by such a method; and a pharmaceutical composition or treatment agent including a layered cell sheet.
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Inventors:
YAMASHITA JUN (JP)
TABATA YASUHIKO (JP)
MATSUO TAKEHIKO (JP)
TABATA YASUHIKO (JP)
MATSUO TAKEHIKO (JP)
Application Number:
PCT/JP2014/064384
Publication Date:
December 04, 2014
Filing Date:
May 30, 2014
Export Citation:
Assignee:
IHEART JAPAN CORP (JP)
International Classes:
C12N5/0735; A61L27/00; A61P9/00; C12N5/07; C12N5/10
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Other References:
TAKEHIKO MATSUO ET AL.: "Shinzo Soshiki Sheet Taso Sekisoka ni Okeru Gelatin Hydrogel Biryushi no Yukosei", REGENERATIVE MEDICINE, vol. 13, 2014, pages 203
SHIMIZU T. ET AL.: "Cell sheet engineering for myocardial tissue reconstruction.", BIOMATERIALS, vol. 24, 2003, pages 2309 - 2316, XP004420022
KO SUGIBAYASHI ET AL.: "Sei Bunkaisei Hydrogel Sonyu ni yoru Sekisoka Saibo Sheet eno Kekkan'yo Kanku Kozo no Sakusei", REGENERATIVE MEDICINE, vol. 9, 2010, pages 176, XP008182689
HAYASHI K. ET AL.: "Preparation of stem cell aggregates with gelatin microspheres to enhance biological functions.", ACTA BIOMATERIALIA, vol. 7, 2011, pages 2797 - 2803, XP028222110
MASUMOTO H. ET AL.: "Pluripotent Stem Cell - Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte -Mediated Neovascularization.", STEM CELLS, vol. 30, no. 6, 2012, pages 1196 - 1205, XP055298190
HARAGUCHI Y. ET AL.: "Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro.", NATURE PROTOCOLS, vol. 7, no. 5, 2012, pages 850 - 858, XP055291922
SASAGAWA T. ET AL.: "Design of prevascularized three-dimensional cell -dense tissues using a cell sheet stacking manipulation technology.", BIOMATERIALS, vol. 31, 2010, pages 1646 - 1654, XP026827522
YAMASHITA J ET AL., NATURE, vol. 408, 2000, pages 92 - 6
YAMASHITA JK ET AL., FASEB J., vol. 19, 2005, pages 1534 - 6
MASUMOTO H ET AL., STEM CELLS, vol. 30, 2012, pages 1196 - 205
HAYASHI K; TABATA Y., ACTA BIOMATER., vol. 7, 2011, pages 2797 - 803
HUANGFU D ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 795 - 797
SHI Y ET AL., CELL STEM CELL, vol. 2, 2008, pages 525 - 528
EMINLI S ET AL., STEM CELLS, vol. 26, 2008, pages 2467 - 2474
HUANGFU D ET AL., NAT BIOTECHNOL., vol. 26, 2008, pages 1269 - 1275
SHI Y ET AL., CELL STEM CELL, vol. 3, 2008, pages 568 - 574
ZHAO Y ET AL., CELL STEM CELL, vol. 3, 2008, pages 475 - 479
MARSON A, CELL STEM CELL, vol. 3, 2008, pages 132 - 135
FENG B ET AL., NAT CELL BIOL., vol. 11, 2009, pages 197 - 203
R.L. JUDSON ET AL., NAT. BIOTECH., vol. 27, 2009, pages 459 - 461
LYSSIOTIS CA ET AL., PROC NATL ACAD SCI U S A., vol. 106, 2009, pages 8912 - 8917
KIM JB ET AL., NATURE, vol. 461, 2009, pages 649 - 643
ICHIDA JK ET AL., CELL STEM CELL, vol. 5, 2009, pages 491 - 503
HENG JC ET AL., CELL STEM CELL, vol. 6, 2010, pages 167 - 74
HAN J ET AL., NATURE, vol. 463, 2010, pages 1096 - 100
MALI P ET AL., STEM CELLS, vol. 28, 2010, pages 713 - 720
MAEKAWA M ET AL., NATURE, vol. 474, 2011, pages 225 - 9
LAFLAMME MA; MURRY CE, NATURE, 2011
CELL., vol. 122, no. 6, 23 September 2005 (2005-09-23), pages 947 - 56
STEM CELLS, vol. 22, no. 1, 2004, pages 51 - 64
MOL BIOL CELL, vol. 13, no. 4, April 2002 (2002-04-01), pages 1274 - 81
CHEN CH ET AL., BIOMACROMOLECULES, vol. 7, 2006, pages 736 - 43
TAKAMOTO Y ET AL., J. BIOMATER. SCI. POLYMER EDN, vol. 18, 2007, pages 1211 - 1222
YAMASHITA JK, FASEB J., vol. 19, 2005, pages 1534 - 6
ZAMBROWICZ BP, PROC NATL ACAD SCI USA, vol. 94, 1997, pages 3789 - 3794
YAMASHITA JK ET AL., FASEB J, vol. 19, 2005, pages 1534 - 6
YURUGI-KOBAYASHI T ET AL., ARTERIOSCLER THROMBVASC BIOL., vol. 26, 2006, pages 1977 - 84
YAN P ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 379, 2009, pages 115 - 20
MASUMOTO H ET AL., STEM CELLS, 2012, pages 301196 - 205
MASUMOTO H ET AL., STEM CELL, vol. 30, 2012, pages 1196 - 1205
MASUMOTO H ET AL.: "the same as above", STEM CELL, vol. 30, 2012, pages 1196 - 1205
NISHINA T ET AL., CIRCULATION, vol. 104, 2001, pages 1241 - 1245
SAKAKIBARA Y. ET AL., CIRCULATION, vol. 104, no. 106, 2002, pages 1193 - 1197
See also references of EP 3006559A4
SHIMIZU T. ET AL.: "Cell sheet engineering for myocardial tissue reconstruction.", BIOMATERIALS, vol. 24, 2003, pages 2309 - 2316, XP004420022
KO SUGIBAYASHI ET AL.: "Sei Bunkaisei Hydrogel Sonyu ni yoru Sekisoka Saibo Sheet eno Kekkan'yo Kanku Kozo no Sakusei", REGENERATIVE MEDICINE, vol. 9, 2010, pages 176, XP008182689
HAYASHI K. ET AL.: "Preparation of stem cell aggregates with gelatin microspheres to enhance biological functions.", ACTA BIOMATERIALIA, vol. 7, 2011, pages 2797 - 2803, XP028222110
MASUMOTO H. ET AL.: "Pluripotent Stem Cell - Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte -Mediated Neovascularization.", STEM CELLS, vol. 30, no. 6, 2012, pages 1196 - 1205, XP055298190
HARAGUCHI Y. ET AL.: "Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro.", NATURE PROTOCOLS, vol. 7, no. 5, 2012, pages 850 - 858, XP055291922
SASAGAWA T. ET AL.: "Design of prevascularized three-dimensional cell -dense tissues using a cell sheet stacking manipulation technology.", BIOMATERIALS, vol. 31, 2010, pages 1646 - 1654, XP026827522
YAMASHITA J ET AL., NATURE, vol. 408, 2000, pages 92 - 6
YAMASHITA JK ET AL., FASEB J., vol. 19, 2005, pages 1534 - 6
MASUMOTO H ET AL., STEM CELLS, vol. 30, 2012, pages 1196 - 205
HAYASHI K; TABATA Y., ACTA BIOMATER., vol. 7, 2011, pages 2797 - 803
HUANGFU D ET AL., NAT. BIOTECHNOL., vol. 26, 2008, pages 795 - 797
SHI Y ET AL., CELL STEM CELL, vol. 2, 2008, pages 525 - 528
EMINLI S ET AL., STEM CELLS, vol. 26, 2008, pages 2467 - 2474
HUANGFU D ET AL., NAT BIOTECHNOL., vol. 26, 2008, pages 1269 - 1275
SHI Y ET AL., CELL STEM CELL, vol. 3, 2008, pages 568 - 574
ZHAO Y ET AL., CELL STEM CELL, vol. 3, 2008, pages 475 - 479
MARSON A, CELL STEM CELL, vol. 3, 2008, pages 132 - 135
FENG B ET AL., NAT CELL BIOL., vol. 11, 2009, pages 197 - 203
R.L. JUDSON ET AL., NAT. BIOTECH., vol. 27, 2009, pages 459 - 461
LYSSIOTIS CA ET AL., PROC NATL ACAD SCI U S A., vol. 106, 2009, pages 8912 - 8917
KIM JB ET AL., NATURE, vol. 461, 2009, pages 649 - 643
ICHIDA JK ET AL., CELL STEM CELL, vol. 5, 2009, pages 491 - 503
HENG JC ET AL., CELL STEM CELL, vol. 6, 2010, pages 167 - 74
HAN J ET AL., NATURE, vol. 463, 2010, pages 1096 - 100
MALI P ET AL., STEM CELLS, vol. 28, 2010, pages 713 - 720
MAEKAWA M ET AL., NATURE, vol. 474, 2011, pages 225 - 9
LAFLAMME MA; MURRY CE, NATURE, 2011
CELL., vol. 122, no. 6, 23 September 2005 (2005-09-23), pages 947 - 56
STEM CELLS, vol. 22, no. 1, 2004, pages 51 - 64
MOL BIOL CELL, vol. 13, no. 4, April 2002 (2002-04-01), pages 1274 - 81
CHEN CH ET AL., BIOMACROMOLECULES, vol. 7, 2006, pages 736 - 43
TAKAMOTO Y ET AL., J. BIOMATER. SCI. POLYMER EDN, vol. 18, 2007, pages 1211 - 1222
YAMASHITA JK, FASEB J., vol. 19, 2005, pages 1534 - 6
ZAMBROWICZ BP, PROC NATL ACAD SCI USA, vol. 94, 1997, pages 3789 - 3794
YAMASHITA JK ET AL., FASEB J, vol. 19, 2005, pages 1534 - 6
YURUGI-KOBAYASHI T ET AL., ARTERIOSCLER THROMBVASC BIOL., vol. 26, 2006, pages 1977 - 84
YAN P ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 379, 2009, pages 115 - 20
MASUMOTO H ET AL., STEM CELLS, 2012, pages 301196 - 205
MASUMOTO H ET AL., STEM CELL, vol. 30, 2012, pages 1196 - 1205
MASUMOTO H ET AL.: "the same as above", STEM CELL, vol. 30, 2012, pages 1196 - 1205
NISHINA T ET AL., CIRCULATION, vol. 104, 2001, pages 1241 - 1245
SAKAKIBARA Y. ET AL., CIRCULATION, vol. 104, no. 106, 2002, pages 1193 - 1197
See also references of EP 3006559A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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