LEFT-HANDED BICYCLIC MORPHOLINE AND SALT THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATION

WIPO Patent Application WO/2021/103749

A1

The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a left-handed bicyclic morpholine and a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition, and an application thereof in the preparation of drugs for preventing and/or treating liver diseases and the like.

JP2010132662	BENZAMIDE DERIVATIVE AS ANTAGONIST OF OREXIN RECEPTOR
JPH0761994	[Title of Invention] Diselenobis benzoic acid amide, a method for producing the same, and a pharmaceutical preparation containing the same.
JP2636013	[Title of Invention] Biphenyl compound (methylenedioxy)

WU SONG (CN)
SUN HUA (CN)
ZHANG JINLAN (CN)
ZHANG WENXUAN (CN)
WANG ZHE (CN)
YANG QINGYUN (CN)
JIANG LIN (CN)
CHEN ZIHAN (CN)
SHEN JING (CN)
ZHANG JIE (CN)
ZHANG CHI (CN)
HAN ZUNSHENG (CN)
QIN TONG (CN)
ZHANG YUANYUAN (CN)

PCT/CN2020/115410

June 03, 2021

September 15, 2020

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INST MATERIA MEDICA CAMS (CN)

C07D317/68; A61K31/5377; A61P1/16; A61P31/14; A61P31/20; A61P37/02

CN107488162A	2017-12-19
CN1506363A	2004-06-23
CN1837203A	2006-09-27

MIN LI , GENG-TAO LIU: "Inhibition of Fas/FasL mRNA Expression and TNF-α Release in Concanavalin A-Induced Liver Injury in Mice by Bicyclol", WORLD J GASTROENTEROL, vol. 10, no. 12, 15 June 2004 (2004-06-15), pages 1775 - 1779, XP055816661, ISSN: 1007-9327, DOI: 10.3748/wjg.v10.i12.1775
WU SONGSUN HUA ET AL., BICYCLOL DERIVATIVE AND PREPARATIONS AND APPLICATIONS THEREOF
See also references of EP 4050004A4

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