Title:
LEUKOCYTE TRAPPING APPARATUS
Document Type and Number:
WIPO Patent Application WO/2022/070841
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a leukocyte trapping apparatus which does not require a large-size device such as a centrifuge separator and in which the amount of blood to be needed can be reduced to an amount as small as about 1 μl. The problem is solved by a leukocyte trapping apparatus (1) for trapping leukocytes by passing a blood-containing solution therethrough, the leukocyte trapping apparatus (1) being configured such that: a chip (10) has a flat part (12) and many protruding parts (14) arranged on the flat part (12), in which the blood-containing solution that enters through an inlet port (3) is allowed to pass through the surface of the flat part (12) and also allowed to pass through spaces between a protruding part (14) and another protruding part (14) adjacent to the aforementioned protruding part (14) in the chip (10) and is discharged through a discharge port (5); the protruding parts (14) are arranged so as to form layers on the flat part (12), in which each of the layers contains a plurality of the protruding parts (14), and the blood-containing solution that has passed through a layer located on the inlet port (3) side passes through another layer that is adjacent to the aforementioned layer on the discharge port (5) side; a trapping part and a bypass part are formed between a protruding part (14) and another adjacent protruding part (14) in each of the layers; and the trapping part is arranged on the discharge port (5) side of the bypass part in a specific layer as a portion of another layer adjacent to the specific layer.
Inventors:
NAKAMURA ASAKO (JP)
TAKAHASHI KENTA (JP)
KOMORI TAKAYUKI (JP)
TAKAHASHI KENTA (JP)
KOMORI TAKAYUKI (JP)
Application Number:
PCT/JP2021/033343
Publication Date:
April 07, 2022
Filing Date:
September 10, 2021
Export Citation:
Assignee:
NOK CORP (JP)
NATIONAL UNIV CORPORATION IBARAKI UNIV (JP)
NATIONAL UNIV CORPORATION IBARAKI UNIV (JP)
International Classes:
G01N37/00; C12M1/26; G01N1/04; G01N33/48
Foreign References:
| JP2012088055A | 2012-05-10 | |||
| JP2019508050A | 2019-03-28 | |||
| CN102360010A | 2012-02-22 | |||
| JP2009109232A | 2009-05-21 | |||
| JP2009509143A | 2009-03-05 | |||
| JP2009109232A | 2009-05-21 | |||
| JP2020163378A | 2020-10-08 |
Attorney, Agent or Firm:
MIGITA, Shunsuke et al. (JP)
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