Title:
LGR5+ SOMATIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2014/089268
Kind Code:
A3
Abstract:
Described is an isolated somatic stem cell that is 2 to less than 6 micrometer in size and Lgr5+. Methods of preparing and using the cell are also described.
Inventors:
WANG JAMES (US)
Application Number:
PCT/US2013/073253
Publication Date:
November 13, 2014
Filing Date:
December 05, 2013
Export Citation:
Assignee:
STEMBIOS TECHNOLOGIES INC (US)
International Classes:
C12N5/074; A61K35/12; A61K35/14; A61K35/28; A61K35/34; A61K35/35; A61P21/00
Domestic Patent References:
| WO2012019002A2 | 2012-02-09 |
Foreign References:
| US20120028355A1 | 2012-02-02 |
Other References:
BARKER, NICK ET AL.: "Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro", CELL STEM CELL, vol. 6, no. 1, 2010, pages 25 - 36, XP055210573
BARKER, NICK ET AL.: "Identification of stem cells in small intestine and colon by marker gene Lgr5", NATURE, vol. 449, no. 7165, 2007, pages 1003 - 1007, XP002457164
JAKS, VILJAR ET AL.: "Lgr5 marks cycling, yet long-lived, hair follicle stem cells", NATURE GENETICS, vol. 40, no. 11, 2008, pages 1291 - 1299, XP002525637
BARKER, NICK ET AL.: "Identification of stem cells in small intestine and colon by marker gene Lgr5", NATURE, vol. 449, no. 7165, 2007, pages 1003 - 1007, XP002457164
JAKS, VILJAR ET AL.: "Lgr5 marks cycling, yet long-lived, hair follicle stem cells", NATURE GENETICS, vol. 40, no. 11, 2008, pages 1291 - 1299, XP002525637
Attorney, Agent or Firm:
WU, Jeannie (LLP88 Black Falcon Avenu, Boston MA, US)
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