Title:
A LIBRARY OF MODIFIED STRUCTURAL GENES OR CAPSID MODIFIED PARTICLES USEFUL FOR THE IDENTIFICATION OF VIRAL CLONES WITH DESIRED CELL TROPISM
Document Type and Number:
WIPO Patent Application WO2003054197
Kind Code:
A3
Abstract:
This invention relates to a library of nucleic acids comprising a multiplicity of expressible structural genes, preferably cap genes, from an eukaryotic virus, preferably of a parvovirus.
Inventors:
PERABO LUCA (DE)
BUENING HILDEGARD (DE)
ENSSLE JOERG (DE)
RIED MARTIN (DE)
HALLEK MICHAEL (DE)
HUTTNER NADJA (DE)
BUENING HILDEGARD (DE)
ENSSLE JOERG (DE)
RIED MARTIN (DE)
HALLEK MICHAEL (DE)
HUTTNER NADJA (DE)
Application Number:
PCT/EP2002/014750
Publication Date:
March 18, 2004
Filing Date:
December 23, 2002
Export Citation:
Assignee:
MEDIGENE AG (DE)
PERABO LUCA (DE)
BUENING HILDEGARD (DE)
ENSSLE JOERG (DE)
RIED MARTIN (DE)
HALLEK MICHAEL (DE)
HUTTNER NADJA (DE)
PERABO LUCA (DE)
BUENING HILDEGARD (DE)
ENSSLE JOERG (DE)
RIED MARTIN (DE)
HALLEK MICHAEL (DE)
HUTTNER NADJA (DE)
International Classes:
A61K38/00; A61K48/00; A61P31/12; A61P31/20; A61P35/00; C12N15/09; A61P37/00; C07K14/01; C07K14/015; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/33; C12N15/864; C12Q1/02; C12Q1/68; (IPC1-7): C12N15/33; C12N15/864; C07K14/015; A61K38/00; A61K48/00
Domestic Patent References:
| WO2000073478A2 | 2000-12-07 | |||
| WO1997038723A1 | 1997-10-23 |
Other References:
GRIFMAN M ET AL: "Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids.", MOLECULAR THERAPY: THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY. UNITED STATES JUN 2001, vol. 3, no. 6, June 2001 (2001-06-01), pages 964 - 975, XP002235294, ISSN: 1525-0016
GIROD A ET AL: "GENETIC CAPSID MODIFICATIONS ALLOW EFFICIENT RE-TARGETING OF ADENO-ASSOCIATED VIRUS TYPE 2", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 9, September 1999 (1999-09-01), pages 1052 - 1056, XP002128040, ISSN: 1078-8956
NICKLIN STUART A ET AL: "Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy.", CURRENT GENE THERAPY, vol. 2, no. 3, September 2002 (2002-09-01), September, 2002, pages 273 - 293, XP001121288, ISSN: 1566-5232
RABINOWITZ JOSEPH E ET AL: "Building a better vector: The manipulation of AAV virions.", VIROLOGY, vol. 278, no. 2, 20 December 2000 (2000-12-20), pages 301 - 308, XP002235295, ISSN: 0042-6822
GIROD A ET AL: "GENETIC CAPSID MODIFICATIONS ALLOW EFFICIENT RE-TARGETING OF ADENO-ASSOCIATED VIRUS TYPE 2", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 5, no. 9, September 1999 (1999-09-01), pages 1052 - 1056, XP002128040, ISSN: 1078-8956
NICKLIN STUART A ET AL: "Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy.", CURRENT GENE THERAPY, vol. 2, no. 3, September 2002 (2002-09-01), September, 2002, pages 273 - 293, XP001121288, ISSN: 1566-5232
RABINOWITZ JOSEPH E ET AL: "Building a better vector: The manipulation of AAV virions.", VIROLOGY, vol. 278, no. 2, 20 December 2000 (2000-12-20), pages 301 - 308, XP002235295, ISSN: 0042-6822
Download PDF:
Previous Patent: NOVEL GENE USEFUL IN DIAGNOSING CANCER AND USE THEREOF
Next Patent: PHYTASES AND METHOD FOR PRODUCING THESE PHYTASES
Next Patent: PHYTASES AND METHOD FOR PRODUCING THESE PHYTASES