Title:
LIGAND-NUCLEIC ACID CONJUGATE BODY
Document Type and Number:
WIPO Patent Application WO/2022/215704
Kind Code:
A1
Abstract:
The present invention pertains to a conjugate body represented by Lg-Lk-NCA wherein Lk is a linker moiety, NCA is a nucleic acid moiety and Lg is a group represented by one of the formulae.
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Inventors:
OBIKA SATOSHI (JP)
OSAWA TAKASHI (JP)
OKUDA TAKUMI (JP)
KODAMA TETSUYA (JP)
MOAI YOSHIHIRO (JP)
MITSUMORI EIJI (JP)
OHISHI KAZUMA (JP)
NAKANO ATSUSHI (JP)
KASAHARA YUYA (JP)
KAMADA HARUHIKO (JP)
NAKAYAMA TAISUKE (JP)
OSAWA TAKASHI (JP)
OKUDA TAKUMI (JP)
KODAMA TETSUYA (JP)
MOAI YOSHIHIRO (JP)
MITSUMORI EIJI (JP)
OHISHI KAZUMA (JP)
NAKANO ATSUSHI (JP)
KASAHARA YUYA (JP)
KAMADA HARUHIKO (JP)
NAKAYAMA TAISUKE (JP)
Application Number:
PCT/JP2022/017160
Publication Date:
October 13, 2022
Filing Date:
April 06, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
A61K31/7088; A61K31/4523; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61K47/54; A61K47/55; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P25/00; C12N15/113; C12Q1/68
Foreign References:
| US20130066063A1 | 2013-03-14 | |||
| US20210038605A1 | 2021-02-11 |
Other References:
KAWAMATA, YUJI ET AL.: "Development of delivery technology by ligand-added nucleic acid drug DDS", JOURNAL OF NUCLEIC ACID THERAPEUTICS SOCIETY OF JAPAN, NUCLEIC ACID THERAPEUTICS SOCIETY OF JAPAN, JP, vol. 21, no. 1, 1 January 2017 (2017-01-01), JP, pages 22 - 51, XP009540241
YASUO KOMATSU: "Development of terminal or internal chemical modifications of nucleic acids", JOURNAL OF BIOCHEMISTRY, OXFORD UNIVERSITY PRESS, GB, vol. 82, no. 12, 1 December 2010 (2010-12-01), GB , pages 1141 - 1145, XP008173111, ISSN: 0021-924X
TAKAHASHI N, TOMINAGA M, KOSAKA R, KAMATA Y, UMEHARA Y, MATSUDA H, SAKAGUCHI A, OGAWA H, TAKAMORI K: "Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice", ACTA DERMATO-VENEREOLOGICA., TAYLOR & FRANCIS LTD., UNITED KINGDOM, vol. 97, no. 8, 1 January 2017 (2017-01-01), United Kingdom , pages 928 - 933, XP055974873, ISSN: 0001-5555, DOI: 10.2340/00015555-2704
YASUDA DAISUKE: "Requirement of atypical N-glycosylation motif for the surface expression and the intracellular signaling", RESEARCH REPORT OF GRANT-IN-AID FOR SCIENTIFIC RESEARCH, 1 January 2019 (2019-01-01), XP055974876, Retrieved from the Internet [retrieved on 20221026]
FONG PEDRO; TONG HENRY H Y; CHAO CHI M: "In silico prediction of tyrosinase and adenylyl cyclase inhibitors from natural compounds", NATURAL PRODUCT COMMUNICATIONS, vol. 9, 1 February 2014 (2014-02-01), pages 189 - 194, XP009194768, ISSN: 1934-578x
BAEZA GEMA, BACHMAIR EVA-MARIA, WOOD SHARON, MATEOS RAQUEL, BRAVO LAURA, DE ROOS BAUKJE: "The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 8, no. 3, 1 January 2017 (2017-01-01), GB , pages 1333 - 1342, XP055974878, ISSN: 2042-6496, DOI: 10.1039/C6FO01404F
INOUE, TAKAO: "Oligonucleotide therapeutics: past, present and future", DRUG DELIVERY SYSTEM., NIHON D D S GAKKAI, JAPAN, vol. 31, no. 1, 25 January 2016 (2016-01-25), Japan , pages 10 - 23, XP009540548, ISSN: 0913-5006, DOI: 10.2745/dds.31.10
YASUO KOMATSU: "Development of terminal or internal chemical modifications of nucleic acids", JOURNAL OF BIOCHEMISTRY, OXFORD UNIVERSITY PRESS, GB, vol. 82, no. 12, 1 December 2010 (2010-12-01), GB , pages 1141 - 1145, XP008173111, ISSN: 0021-924X
TAKAHASHI N, TOMINAGA M, KOSAKA R, KAMATA Y, UMEHARA Y, MATSUDA H, SAKAGUCHI A, OGAWA H, TAKAMORI K: "Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice", ACTA DERMATO-VENEREOLOGICA., TAYLOR & FRANCIS LTD., UNITED KINGDOM, vol. 97, no. 8, 1 January 2017 (2017-01-01), United Kingdom , pages 928 - 933, XP055974873, ISSN: 0001-5555, DOI: 10.2340/00015555-2704
YASUDA DAISUKE: "Requirement of atypical N-glycosylation motif for the surface expression and the intracellular signaling", RESEARCH REPORT OF GRANT-IN-AID FOR SCIENTIFIC RESEARCH, 1 January 2019 (2019-01-01), XP055974876, Retrieved from the Internet
FONG PEDRO; TONG HENRY H Y; CHAO CHI M: "In silico prediction of tyrosinase and adenylyl cyclase inhibitors from natural compounds", NATURAL PRODUCT COMMUNICATIONS, vol. 9, 1 February 2014 (2014-02-01), pages 189 - 194, XP009194768, ISSN: 1934-578x
BAEZA GEMA, BACHMAIR EVA-MARIA, WOOD SHARON, MATEOS RAQUEL, BRAVO LAURA, DE ROOS BAUKJE: "The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 8, no. 3, 1 January 2017 (2017-01-01), GB , pages 1333 - 1342, XP055974878, ISSN: 2042-6496, DOI: 10.1039/C6FO01404F
INOUE, TAKAO: "Oligonucleotide therapeutics: past, present and future", DRUG DELIVERY SYSTEM., NIHON D D S GAKKAI, JAPAN, vol. 31, no. 1, 25 January 2016 (2016-01-25), Japan , pages 10 - 23, XP009540548, ISSN: 0913-5006, DOI: 10.2745/dds.31.10
Attorney, Agent or Firm:
NAKAMICHI, Yoshihiro et al. (JP)
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