Title:
LIGAND FOR ß2−GLYCOPROTEIN I AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/022866
Kind Code:
A1
Abstract:
A cholesterol derivative represented by the following general formula (1), which specifically bonds to ß2−glycoprotein. By using this derivative, ß2−glycoprotein or the like can be highly practically determined. Based on this determination, diseases can be highly practically detected. (1) In the formula, R represents an optionally substituted, C3−23, (un)saturated aliphatic hydrocarbon residue, and the cholesterol skeleton may have −OH, −CHO, −COOH, −OOH, or an epoxy group added thereto.
Inventors:
MATSUURA EIJI (JP)
KOBAYASHI KAZUKO (JP)
KOBAYASHI KAZUKO (JP)
Application Number:
PCT/JP2002/000723
Publication Date:
March 20, 2003
Filing Date:
January 30, 2002
Export Citation:
Assignee:
MATSUURA EIJI (JP)
KOBAYASHI KAZUKO (JP)
KOBAYASHI KAZUKO (JP)
International Classes:
C07J9/00; C07J17/00; G01N33/68; G01N33/92; (IPC1-7): C07J9/00; G01N33/53; G01N33/564
Domestic Patent References:
| WO1982003175A1 | 1982-09-30 | |||
| WO1995009363A1 | 1995-04-06 |
Foreign References:
| US4304726A | 1981-12-08 |
Other References:
J. LIPID RES., vol. 42, no. 5, 2001, pages 697 - 709, XP002951004
J. LIPID RES., vol. 41, no. 2, 2000, pages 226 - 236, XP002951005
BIOORG. KHIM., vol. 23, no. 8, 1997, pages 675 - 679, XP002951006
J. LIPID RES., vol. 37, no. 2, 1996, pages 320 - 325, XP002951007
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LIPIDS, vol. 28, no. 4, 1993, pages 331 - 336, XP002951009
FEBS LETT., vol. 304, no. 2-3, 1992, pages 269 - 272, XP002951010
J. CHEM. RES., SYNOP., no. 5, 1992, pages 168 - 169, XP002951011
ACTA CHIM. HUNG., vol. 127, no. 5, 1990, pages 705 - 710, XP002951012
J. CHEM. RES., SYNOP., no. 10, 1986, pages 384 - 385, XP002951013
J. STEROID BIOCHEM., vol. 14, no. 6, 1981, pages 569 - 573, XP002951014
J. LIPID RES., vol. 41, no. 2, 2000, pages 226 - 236, XP002951005
BIOORG. KHIM., vol. 23, no. 8, 1997, pages 675 - 679, XP002951006
J. LIPID RES., vol. 37, no. 2, 1996, pages 320 - 325, XP002951007
J. LIPID RES., vol. 36, no. 9, 1995, pages 1876 - 1886, XP002951008
LIPIDS, vol. 28, no. 4, 1993, pages 331 - 336, XP002951009
FEBS LETT., vol. 304, no. 2-3, 1992, pages 269 - 272, XP002951010
J. CHEM. RES., SYNOP., no. 5, 1992, pages 168 - 169, XP002951011
ACTA CHIM. HUNG., vol. 127, no. 5, 1990, pages 705 - 710, XP002951012
J. CHEM. RES., SYNOP., no. 10, 1986, pages 384 - 385, XP002951013
J. STEROID BIOCHEM., vol. 14, no. 6, 1981, pages 569 - 573, XP002951014
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)
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