Title:
LIGANDS OF INSULIN DEGRADING ENZYME AND THEIR USES
Document Type and Number:
WIPO Patent Application WO/2011/107948
Kind Code:
A3
Abstract:
The invention relates to ligands of insulin degrading enzyme and to their uses. The ligands of the invention are non peptidic and bind specifically to the exosite of insulin degrading enzyme. They are useful, in particular a use in the pharmaceutical field. Formula (I) (I) wherein: R is a (L) or (D) aminoacid derivative having the following formula (II): (II)
Inventors:
DEPREZ-POULAIN REBECCA FRANZISKA (FR)
CHARTON JULIE JEANNE MARINE (FR)
DEPREZ BENOÎT GASTON PIERRE (FR)
LEROUX FLORENCE CATHERINE GILBERTE (FR)
GAURIOT MARION (FR)
TANG WEI-JEN (US)
TOTOBENAZARA JANE (FR)
CHARTON JULIE JEANNE MARINE (FR)
DEPREZ BENOÎT GASTON PIERRE (FR)
LEROUX FLORENCE CATHERINE GILBERTE (FR)
GAURIOT MARION (FR)
TANG WEI-JEN (US)
TOTOBENAZARA JANE (FR)
Application Number:
PCT/IB2011/050886
Publication Date:
November 26, 2015
Filing Date:
March 02, 2011
Export Citation:
Assignee:
UNIV LILLE II DROIT & SANTE (FR)
DEPREZ-POULAIN REBECCA FRANZISKA (FR)
CHARTON JULIE JEANNE MARINE (FR)
DEPREZ BENOÎT GASTON PIERRE (FR)
LEROUX FLORENCE CATHERINE GILBERTE (FR)
GAURIOT MARION (FR)
TANG WEI-JEN (US)
TOTOBENAZARA JANE (FR)
DEPREZ-POULAIN REBECCA FRANZISKA (FR)
CHARTON JULIE JEANNE MARINE (FR)
DEPREZ BENOÎT GASTON PIERRE (FR)
LEROUX FLORENCE CATHERINE GILBERTE (FR)
GAURIOT MARION (FR)
TANG WEI-JEN (US)
TOTOBENAZARA JANE (FR)
International Classes:
A61P25/28; A61K31/404; A61K31/4164; A61K31/4178; C07D209/20; C07D233/64; C07D401/12; C07D403/12; C07D413/06; C07K5/02; C07K5/06
Domestic Patent References:
| WO1998022433A1 | 1998-05-28 | |||
| WO2004067520A1 | 2004-08-12 |
Other References:
MOORE ET AL.: "Inhibition of beta-amyloid formation as a therapeutic strategy", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 9, no. 2, 1 January 1999 (1999-01-01), pages 135 - 146, XP002582252
Attorney, Agent or Firm:
NOËL, Chantal et al. (36 rue de St Pétersbourg, Paris, FR)
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