Title:
LIGHT CHAIN MUTANT OF BOTULINUM TOXIN
Document Type and Number:
WIPO Patent Application WO/2024/080682
Kind Code:
A1
Abstract:
The present invention provides a light chain mutant of botulinum toxin obtained by substituting a specific lysine with arginine in the light chain of botulinum toxin. The light chain mutant of botulinum toxin according to the present invention has a significantly increased in vivo half-life due to the suppression of degradation by the ubiquitin-proteasome system.
Inventors:
BAEK KWANG-HYUN (KR)
CHOI HAE-SEUL (KR)
LEE MYUNGHOON (KR)
CHOI HAE-SEUL (KR)
LEE MYUNGHOON (KR)
Application Number:
PCT/KR2023/015475
Publication Date:
April 18, 2024
Filing Date:
October 10, 2023
Export Citation:
Assignee:
ALKEMIER INC (KR)
International Classes:
C12N9/52; C07K14/33; C12N15/63
Foreign References:
| KR20180070563A | 2018-06-26 | |||
| KR20190025906A | 2019-03-12 | |||
| KR20180080205A | 2018-07-11 | |||
| KR20190010720A | 2019-01-30 | |||
| US7341843B2 | 2008-03-11 |
Attorney, Agent or Firm:
OH, Kook-Jin (KR)
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