Title:
LIGHT-EMITTING NANOPARTICLES, CELL DETECTION METHOD USING SAME, ANIMAL TREATMENT METHOD, MEDICAL DEVICE, CELL VISUALIZATION METHOD, AND METHOD FOR REDUCING INJURY TO CELL
Document Type and Number:
WIPO Patent Application WO/2017/170531
Kind Code:
A1
Abstract:
Provided are light-emitting nanoparticles that exhibit light emission stability and light resistance, and are less biologically toxic. The light-emitting nanoparticles contain a matrix material and a light-emitting substance included in the matrix material, wherein the matrix material contains a cationic element that is at least one member selected from the group consisting of Ti, Si, Ca, Al and Zr, and an anionic element that is at least one member selected from the group consisting of O and P; and the concentration of the light-emitting substance in the matrix material is set to a level that results in an average distance of 1.2 nm or more between pieces of the light-emitting substance.
Inventors:
INUI MASAHIKO (JP)
CHATANI SUNAO (JP)
TAGAYA MOTOHIRO (JP)
MOTOZUKA SATOSHI (JP)
CHATANI SUNAO (JP)
TAGAYA MOTOHIRO (JP)
MOTOZUKA SATOSHI (JP)
Application Number:
PCT/JP2017/012605
Publication Date:
October 05, 2017
Filing Date:
March 28, 2017
Export Citation:
Assignee:
OHARA QUARTZ CO LTD (JP)
NAT UNIV CORP NAGAOKA UNIV OF TECH (JP)
NAT INST OF TECH (JP)
NAT UNIV CORP NAGAOKA UNIV OF TECH (JP)
NAT INST OF TECH (JP)
International Classes:
C09K11/59; A61K9/51; A61K41/00; A61K47/02; A61P35/00; B82Y5/00; B82Y20/00; B82Y30/00; C09K11/06; C09K11/67; C09K11/71; G01N21/64; G01N21/78; G01N33/48
Other References:
TAGAYA, M. ET AL.: "Synthesis of Luminescent Nanoporous Silica Spheres Functionalized with Folic Acid for Targeting to Cancer Cells", INORGANIC CHEMISTRY, vol. 53, 2014, pages 6817 - 6827, XP055430105
TAGAYA, M. ET AL.: "In Vitro Targeting of Cancer Cells with Luminescent Nanoporous Silica Spheres", TRANSACTIONS ON GIGAKU, vol. 1, no. 01014, 2012, pages 1 - 8, XP009514948
TAGAYA, M. ET AL.: "Synthesis and Luminescence Properties of Eu(III)-doped Nanoporous Silica Spheres", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 363, no. 2, 2011, pages 456 - 464, XP028288398
TAGAYA, M. ET AL.: "Efficient Synthesis of Eu (III)-Containing Nanoporous Silicas", MATERIALS LETTERS, vol. 65, no. 14, 2011, pages 2287 - 2290, XP028387401
MOTOHIRO TAGAYA: "Koji Kozo Seigyo sareta Muki/ Yuki Nano Fukugotai no Sosei to Hikari Kinoka", DV-XA KENKYU KYOKAI KAIHO, vol. 26, no. 1 to 2, 2014, pages 22 - 26, XP009516000, ISSN: 1346-5015
SHIBA, K. ET AL.: "Synthesis of Cytocompatible Luminescent Titania/Fluorescein Hybrid Nanoparticles", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 9, 2014, pages 6825 - 6834, XP055430110
SHIBA, K. ET AL.: "Preparation of Luminescent Titania/Dye Hybrid Nanoparticles and Their Dissolution Properties for Controlling Cellular Environments", RSC ADVANCES, vol. 5, no. 5, 2015, pages 104343 - 104353, XP055430114
RYUHEI TAKEDA ET AL.: "Eu Tenka Apatite Ryushi no Gosei to Hakko Tokusei", DV-XQI KENKYUKAI KAIHO, vol. 24, no. 1-2, 2012, pages 243 - 246, XP009515994, ISSN: 1346-5015
TAGAYA, M. ET AL.: "In Vitro Targeting of Cancer Cells with Luminescent Nanoporous Silica Spheres", TRANSACTIONS ON GIGAKU, vol. 1, no. 01014, 2012, pages 1 - 8, XP009514948
TAGAYA, M. ET AL.: "Synthesis and Luminescence Properties of Eu(III)-doped Nanoporous Silica Spheres", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 363, no. 2, 2011, pages 456 - 464, XP028288398
TAGAYA, M. ET AL.: "Efficient Synthesis of Eu (III)-Containing Nanoporous Silicas", MATERIALS LETTERS, vol. 65, no. 14, 2011, pages 2287 - 2290, XP028387401
MOTOHIRO TAGAYA: "Koji Kozo Seigyo sareta Muki/ Yuki Nano Fukugotai no Sosei to Hikari Kinoka", DV-XA KENKYU KYOKAI KAIHO, vol. 26, no. 1 to 2, 2014, pages 22 - 26, XP009516000, ISSN: 1346-5015
SHIBA, K. ET AL.: "Synthesis of Cytocompatible Luminescent Titania/Fluorescein Hybrid Nanoparticles", ACS APPLIED MATERIALS & INTERFACES, vol. 6, no. 9, 2014, pages 6825 - 6834, XP055430110
SHIBA, K. ET AL.: "Preparation of Luminescent Titania/Dye Hybrid Nanoparticles and Their Dissolution Properties for Controlling Cellular Environments", RSC ADVANCES, vol. 5, no. 5, 2015, pages 104343 - 104353, XP055430114
RYUHEI TAKEDA ET AL.: "Eu Tenka Apatite Ryushi no Gosei to Hakko Tokusei", DV-XQI KENKYUKAI KAIHO, vol. 24, no. 1-2, 2012, pages 243 - 246, XP009515994, ISSN: 1346-5015
Attorney, Agent or Firm:
SHOBAYASHI, Masayuki et al. (JP)
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