Title:
LIGHT-SENSITIVE ION-PASSING MOLECULES
Document Type and Number:
WIPO Patent Application WO/2011/116238
Kind Code:
A3
Abstract:
Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Inventors:
ZHANG FENG (US)
DEISSEROTH KARL (US)
DEISSEROTH KARL (US)
Application Number:
PCT/US2011/028893
Publication Date:
November 10, 2011
Filing Date:
March 17, 2011
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
ZHANG FENG (US)
DEISSEROTH KARL (US)
ZHANG FENG (US)
DEISSEROTH KARL (US)
International Classes:
C12N5/071; C07H21/00; C12N13/00
Foreign References:
| US20090093403A1 | 2009-04-09 | |||
| US20090054954A1 | 2009-02-26 |
Other References:
SWANSON: "Lights, Opsins, Action! Optogenetics brings complex neuronal circuits into sharper focus", 16 December 2009 (2009-12-16), Retrieved from the Internet [retrieved on 20110830]
DATABASE SWISS-PROT [online] 31 October 2006 (2006-10-31), retrieved from http://www.ncbi.nlm.nih.gov/protein/Q2QCJ4 Database accession no. Q2QCJ4
CARDIN ET AL.: "Driving fast-spiking cells induces gamma rhythm and controls sensory responses.", NATURE. 2009, vol. 459, no. 7247, 26 April 2009 (2009-04-26), pages 663 - 7
JEKELY: "Evolution of phototaxis.", PHIL. TRANS. R. SOC. B, vol. 364, 2009, pages 2795 - 2808
GRADINARU ET AL.: "eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications.", BRAIN CELL BIOL., vol. 36, no. 1-4, 2008, pages 129 - 139, XP002557433, DOI: doi:10.1007/s11068-008-9027-6
DATABASE SWISS-PROT [online] 31 October 2006 (2006-10-31), retrieved from http://www.ncbi.nlm.nih.gov/protein/Q2QCJ4 Database accession no. Q2QCJ4
CARDIN ET AL.: "Driving fast-spiking cells induces gamma rhythm and controls sensory responses.", NATURE. 2009, vol. 459, no. 7247, 26 April 2009 (2009-04-26), pages 663 - 7
JEKELY: "Evolution of phototaxis.", PHIL. TRANS. R. SOC. B, vol. 364, 2009, pages 2795 - 2808
GRADINARU ET AL.: "eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications.", BRAIN CELL BIOL., vol. 36, no. 1-4, 2008, pages 129 - 139, XP002557433, DOI: doi:10.1007/s11068-008-9027-6
Attorney, Agent or Firm:
CRAWFORD, Robert, J. (1150 Northland Drive Ste 10, St. Paul MN, US)
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