Title:
ON-LINE SOLID-PHASE EXTRACTION COLUMN WITH MONO-DISPERSION AND HIGH SPECIFIC SURFACE AREA AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2015/139462
Kind Code:
A1
Abstract:
Disclosed are an on-line solid-phase extraction column with mono-dispersion and a high specific surface area, and a preparation method therefor, belonging to the field of solid-phase extractions. A membrane emulsification-suspension polymerization method is used to prepare a mono-dispersed styrene-divinylbenzene copolymer microsphere, which then undergoes a Friedel-Crafts reaction to prepare a hypercrosslinked microsphere, and finally the hypercrosslinked microspheres are packed into an on-line SPE microcolumn by an equidensity homogenation method. The membrane emulsification-suspension polymerization method is used in the present invention. The obtained microsphere has a homogeneous particle size and it is convenient to adjust the particle size, crosslinking degree, etc. It is convenient to adjust the specific surface area and surface polarity such that a microsphere having a high specific surface area and a certain polarity can be obtained. The equidensity homogenation method is used to fill the on-line SPE microcolumn, and the obtained microcolumn has an easily adjustable polarity and structure, a small sample amount and a good enrichment and separation effect, can be applied to the liquid-phase chromatographic analysis field, and greatly improves the automation degree of the analysis. The on-line SPE column obtained in the present invention can be applied in the fields of analytical chemistry etc.
Inventors:
LI AIMIN (CN)
TANG SONGLIN (CN)
ZHONG SHENG (CN)
ZHOU QING (CN)
ZHANG MANCHENG (CN)
TANG SONGLIN (CN)
ZHONG SHENG (CN)
ZHOU QING (CN)
ZHANG MANCHENG (CN)
Application Number:
PCT/CN2014/090304
Publication Date:
September 24, 2015
Filing Date:
November 05, 2014
Export Citation:
Assignee:
NANJING UNIVERSITY OF TECHNOLOGY (CN)
JIANGSU ENVIRONMENTAL MONITORING (CN)
JIANGSU ENVIRONMENTAL MONITORING (CN)
International Classes:
C08F212/08; B01D15/22; C08F8/24; C08F212/36
Foreign References:
| CN102294228A | 2011-12-28 | |||
| CN1772774A | 2006-05-17 | |||
| CN103387717A | 2013-11-13 | |||
| CN102580353A | 2012-07-18 | |||
| CZ13094A3 | 1996-12-11 |
Other References:
ZHONG, SHENG ET AL.: "Research of Uniform-sized Microspheres Used for HPLC Synthesized With Membrane Emulsification-Suspension Polymerization", CHI JIU XING YOU JI WU RAN WU LUN TAN 2008 JI DI SAN JIE CHI JIU XING YOU JI WU RAN WU QUAN GUO XUE SHU YAN TAO HUI LUN WEN JI, 1 May 2008 (2008-05-01)
Attorney, Agent or Firm:
ZHISHI LAW FIRM OF INTELLECTUAL PROPERTY (CN)
南京知识律师事务所 (CN)
南京知识律师事务所 (CN)
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