Title:
LINEAR PEPTIDE ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2015/023898
Kind Code:
A8
Abstract:
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Inventors:
SMITH PETER ANDREW (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
CRAWFORD JAMES JOHN (US)
ROBERTS TUCKER CURRAN (US)
HIGUCHI ROBERT I (US)
PARASELLI PRASUNA (US)
KOEHLER MICHAEL F T (US)
CRAWFORD JAMES JOHN (US)
Application Number:
PCT/US2014/051151
Publication Date:
March 24, 2016
Filing Date:
August 14, 2014
Export Citation:
Assignee:
RQX PHARMACEUTICALS INC (US)
GENENTECH INC (US)
GENENTECH INC (US)
International Classes:
C07K7/08; A01N37/44; A01N63/00; A61K38/10; A61P31/00
Attorney, Agent or Firm:
HOSTETLER, Michael, J. (650 Page Mill RoadPalo Alto, CA, US)
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