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Title:
LIPID A ANALOGUES HAVING GLUCOSE AS THE RIGHT SUGAR
Document Type and Number:
WIPO Patent Application WO/2004/058788
Kind Code:
A1
Abstract:
Compounds represented by the general formula (&Verbar ) or pharmacologically acceptable salts thereof: (&Verbar ) wherein Q is oxygen, C1-3 alkylene, -O-Alk-, or -O-Alk-O- (wherein Alk is C1-3 alkylene); R1, R2, and R4 are each independently hydrogen, optionally substituted C1-20 alkyl, optionally substituted C2-20 alkenyl, optionally substituted C2-20 alkynyl, optionally substituted C1-20 alkanoyl, optionally substituted C3-20 alkenoyl, or optionally substituted C3-20 alkynoyl; R3 is optionally substituted C1-20 alkanoyl, optionally substituted C3-20 alkenoyl, or optionally substituted C3-20 alkynoyl; and R5 is hydrogen, halogeno, hydroxyl, optionally substituted C1-6 alkoxy, optionally substituted C2-6 alkenyloxy, or optionally substituted C2-6 alkynyloxy.

Inventors:
Shiozaki, Masao (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
Shimozato, Takaichi (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
Application Number:
PCT/JP2003/016483
Publication Date:
July 15, 2004
Filing Date:
December 22, 2003
Export Citation:
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Assignee:
SANKYO COMPANY, LIMITED (5-1 Nihonbashi Honcho 3-chome, Chuo-ku, Tokyo, 103-8426, JP)
Watanabe, Yukiko (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
Mochizuki, Takashi (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
Shiozaki, Masao (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
Shimozato, Takaichi (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
International Classes:
A61K31/7028; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P43/00; C07H15/18; (IPC1-7): C07H15/18; A61K31/7028; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
2001-10-18
1998-10-01
1991-02-21
Foreign References:
US5935938A1999-08-10
EP0536969A21993-04-14
EP0192296A11986-08-27
Other References:
HOMMA, Y ET AL: 'Structural Requirements of Lipid A Responsible for the Functions : A Study with Chemically Synthezed Lipid A and Its Analogues' JOURNAL OF THE BIOCHEMISTRY vol. 98, no. 2, 1985, pages 395 - 406, XP002975864
Attorney, Agent or Firm:
Ohno, Akio (Sankyo Company, Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, 140-8710, JP)
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