Title:
LIPID COMPOSITIONS AND THEIR USES FOR INTRATUMORAL POLYNUCLEOTIDE DELIVERY
Document Type and Number:
WIPO Patent Application WO/2017/180917
Kind Code:
A3
Abstract:
The present application provides a composition comprising (1) a lipid composition comprising an ionizable amino lipid and a quaternary amine compound and (2) a polynucleotide. The present application also provides a composition comprising (1) a lipid composition comprising an asymmetric phospholipid, an ionizable amino lipid, and optionally a quaternary amine compound and (2) a polynucleotide, wherein the composition is formulated for intratumoral delivery of the polynucleotide. The present application further provides pharmaceutical compositions for intratumoral delivery comprising (1) a lipid composition comprising a compound of formula (I) and (2) therapeutic agent or a polynucleotide encoding the therapeutic agent, e.g., an mRNA encoding a therapeutic protein or a fragment thereof. Further provided is a method of increasing retention of a polynucleotide in a tumor tissue by using such a composition.
Inventors:
BENENATO KERRY (US)
YING BO (US)
YING BO (US)
Application Number:
PCT/US2017/027492
Publication Date:
December 14, 2017
Filing Date:
April 13, 2017
Export Citation:
Assignee:
MODERNATX INC (US)
International Classes:
A61K47/44
Domestic Patent References:
| WO2013016058A1 | 2013-01-31 | |||
| WO2013052523A1 | 2013-04-11 | |||
| WO2015199952A1 | 2015-12-30 | |||
| WO2009086558A1 | 2009-07-09 |
Attorney, Agent or Firm:
KIM, Ji-Eun et al. (US)
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