Title:
LIPID COMPOUND, AND COMPOSITION, PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/216423
Kind Code:
A1
Abstract:
Disclosed in the present invention are a lipid compound as represented by a general formula and a composition, and the preparation and the use thereof. The lipid compound of the present invention is a compound based on cholic acid or a derivative thereof, or a pharmaceutically acceptable salt of the compound. The lipid compound and the composition thereof of the present invention can provide a greater choice of vectors for the delivery of nucleic acid drugs, gene vaccines, polypeptides, proteins, antibodies, small-molecule drugs, etc.
Inventors:
ZHAO FENGXIANG (CN)
LU QINGQING (CN)
HU HONGPENG (CN)
GENG YICHENG (CN)
JIANG JIANHAO (CN)
ZHONG TIANYI (CN)
LU QINGQING (CN)
HU HONGPENG (CN)
GENG YICHENG (CN)
JIANG JIANHAO (CN)
ZHONG TIANYI (CN)
Application Number:
PCT/CN2022/107846
Publication Date:
November 16, 2023
Filing Date:
July 26, 2022
Export Citation:
Assignee:
SUZHOU HEALIRNA BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07J9/00; A61K47/28
Foreign References:
| CN101891791A | 2010-11-24 | |||
| CN101798332B | 2011-12-14 | |||
| US5583239A | 1996-12-10 | |||
| US5250524A | 1993-10-05 | |||
| US10519192B2 | 2019-12-31 | |||
| US5780444A | 1998-07-14 |
Other References:
SHIV K. SHARMA ET AL.: "The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. 15, 13 July 2018 (2018-07-13), XP055830862, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00632
POONAM SINGLA ET AL.: "Bile Acid Oligomers and Their Combination with Antibiotics To Combat Bacterial Infections", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. volume 22, 2 November 2018 (2018-11-02), XP093079379, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01433
HENDRA M. WILLEMEN ET AL.: "Alkyl Derivatives of Cholic Acid as Organogelators:One-Component and Two-Component Gels", LANGMUIR, vol. 18, no. 19, 2 July 2002 (2002-07-02), XP055630790, ISSN: 0743-7463, DOI: 10.1021/la025514l
WALKER S, ET AL: "Cationic facial amphiphiles: A pomising class of transfection agents", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 93, no. 4, 1 February 1996 (1996-02-01), pages 1585 - 1590, XP002290328, ISSN: 0027-8424, DOI: 10.1073/pnas.93.4.1585
R. K. DELONG ET AL.: "Novel Cationic Amphiphiles as Delivery Agents for Antisense Oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 27, no. 16, 15 August 1999 (1999-08-15), XP093002241, ISSN: 0305-1048, DOI: 10.1093/nar/27.16.3334
POONAM SINGLA ET AL.: "Bile Acid Oligomers and Their Combination with Antibiotics To Combat Bacterial Infections", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, no. volume 22, 2 November 2018 (2018-11-02), XP093079379, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01433
HENDRA M. WILLEMEN ET AL.: "Alkyl Derivatives of Cholic Acid as Organogelators:One-Component and Two-Component Gels", LANGMUIR, vol. 18, no. 19, 2 July 2002 (2002-07-02), XP055630790, ISSN: 0743-7463, DOI: 10.1021/la025514l
WALKER S, ET AL: "Cationic facial amphiphiles: A pomising class of transfection agents", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 93, no. 4, 1 February 1996 (1996-02-01), pages 1585 - 1590, XP002290328, ISSN: 0027-8424, DOI: 10.1073/pnas.93.4.1585
R. K. DELONG ET AL.: "Novel Cationic Amphiphiles as Delivery Agents for Antisense Oligonucleotides", NUCLEIC ACIDS RESEARCH, vol. 27, no. 16, 15 August 1999 (1999-08-15), XP093002241, ISSN: 0305-1048, DOI: 10.1093/nar/27.16.3334
Attorney, Agent or Firm:
SUZHOU JIANLI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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