Title:
LIPID COMPOUND, AND COMPOSITION, PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217237
Kind Code:
A1
Abstract:
Disclosed are a lipid compound having a general formula as shown, and a composition, preparation and use thereof. The lipid compound is a compound based on cholic acid or a derivative thereof, or a pharmaceutically acceptable salt thereof. The lipid compound and the composition thereof can provide more carrier options for the delivery of nucleic acid drugs, gene vaccines, polypeptides, proteins, antibodies, small molecule drugs etc.
Inventors:
CHEN ZHONG (CN)
ZHONG TIANYI (CN)
HUANG CONGBAO (CN)
HU HONGPENG (CN)
JIA KAN (CN)
WENG TIANWEI (CN)
LU QINGQING (CN)
GE YOUZHEN (CN)
LI XIAOMING (CN)
GENG YICHENG (CN)
ZHANG LIXIA (CN)
JIANG JIANHAO (CN)
ZHONG TIANYI (CN)
HUANG CONGBAO (CN)
HU HONGPENG (CN)
JIA KAN (CN)
WENG TIANWEI (CN)
LU QINGQING (CN)
GE YOUZHEN (CN)
LI XIAOMING (CN)
GENG YICHENG (CN)
ZHANG LIXIA (CN)
JIANG JIANHAO (CN)
Application Number:
PCT/CN2023/093558
Publication Date:
November 16, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
SUZHOU HEALIRNA BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07J9/00; A61K47/69
Domestic Patent References:
| WO2023048453A1 | 2023-03-30 | |||
| WO2021194298A1 | 2021-09-30 | |||
| WO2021231701A1 | 2021-11-18 |
Foreign References:
| CN101798332A | 2010-08-11 | |||
| CN110804082A | 2020-02-18 |
Other References:
DATABASE Registry 20 April 2022 (2022-04-20), ANONYMOUS: "Cholan-24-oic acid, 3,7,12-trihydroxy-, anhydride with methyl hydrogen carbonate, (3α,5β,7α,12α)-", XP009550506, Database accession no. 1063968-49-9
POONAM SINGLAA,: "Proficiency of nanostructured lipid carriers for the formulation of amphiphilic bile acid oligomers", COLLOIDS AND SURFACESA: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol. 611, no. 2021, 5 November 2020 (2020-11-05), XP086430558, DOI: 10.1016/j.colsurfa.2020.125841
POONAM SINGLAA,: "Proficiency of nanostructured lipid carriers for the formulation of amphiphilic bile acid oligomers", COLLOIDS AND SURFACESA: PHYSICOCHEMICAL AND ENGINEERING ASPECTS, vol. 611, no. 2021, 5 November 2020 (2020-11-05), XP086430558, DOI: 10.1016/j.colsurfa.2020.125841
Attorney, Agent or Firm:
SUZHOU JIANLI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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