Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
LIPID COMPOUNDS AND LIPID NANOPARTICLE COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2023/056917
Kind Code:
A1
Abstract:
Provided herein are lipid compounds that can be used in combination with other lipid components, such as neutral lipids, cholesterol and polymer conjugated lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination. Also provided herein are lipid nanoparticle compositions comprising said lipid compounds.

Inventors:
YING BO (CN)
WANG XIULIAN (CN)
Application Number:
PCT/CN2022/123724
Publication Date:
April 13, 2023
Filing Date:
October 07, 2022
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SUZHOU ABOGEN BIOSCIENCES CO LTD (CN)
International Classes:
C07C219/16; A61K9/10; A61K9/127; A61K31/16; A61K47/18; A61P39/00; C07C229/10; C07C271/16
Domestic Patent References:
WO2021141969A12021-07-15
WO2020219876A12020-10-29
WO2015095340A12015-06-25
WO2022060871A12022-03-24
WO2022159472A12022-07-28
WO2022221697A12022-10-20
WO2012067378A22012-05-24
WO2015199952A12015-12-30
WO2016176330A12016-11-03
WO2015011633A12015-01-29
WO2017112865A12017-06-29
WO2008127688A12008-10-23
WO2008016473A22008-02-07
WO2011015347A12011-02-10
WO2007025008A22007-03-01
WO2001055369A12001-08-02
WO2009075886A12009-06-18
WO2012009644A22012-01-19
WO1999024595A11999-05-20
WO2001055371A12001-08-02
WO2013103659A12013-07-11
WO2012019780A12012-02-16
WO2015002667A12015-01-08
WO2021204175A12021-10-14
WO2013120497A12013-08-22
WO2013120629A12013-08-22
WO2013120500A12013-08-22
WO2013120627A12013-08-22
WO2013120498A12013-08-22
WO2013120626A12013-08-22
WO2013120499A12013-08-22
WO2013120628A12013-08-22
WO2002098443A22002-12-12
WO2003051401A22003-06-26
WO2008052770A22008-05-08
WO2009127230A12009-10-22
WO2006122828A22006-11-23
WO2008083949A22008-07-17
WO2010088927A12010-08-12
WO2010037539A12010-04-08
WO2004004743A12004-01-15
WO2005016376A12005-02-24
WO2006024518A12006-03-09
WO2007095976A22007-08-30
WO2008014979A22008-02-07
WO2008077592A12008-07-03
WO2009030481A12009-03-12
WO2009095226A22009-08-06
WO2011069586A12011-06-16
WO2011026641A12011-03-10
WO2011144358A12011-11-24
WO2012013326A12012-02-02
WO2012089338A12012-07-05
WO2012113513A12012-08-30
WO2012116811A12012-09-07
WO2012116810A12012-09-07
WO2013113502A12013-08-08
WO2013113501A12013-08-08
WO2013113736A12013-08-08
WO2013143698A12013-10-03
WO2013143699A12013-10-03
WO2013143700A22013-10-03
WO2013174409A12013-11-28
WO2014127917A12014-08-28
WO2015024669A12015-02-26
WO2015024668A22015-02-26
WO2015024667A12015-02-26
WO2015024665A12015-02-26
WO2015024666A12015-02-26
WO2015024664A12015-02-26
WO2015101415A12015-07-09
WO2015101414A22015-07-09
WO2015062738A12015-05-07
WO2015101416A12015-07-09
Foreign References:
CN113185421A2021-07-30
US8519110B22013-08-27
US7468275B22008-12-23
US20070048776A12007-03-01
US20110124100A12011-05-26
US6310197B12001-10-30
US6849405B22005-02-01
US7456273B22008-11-25
US7183395B22007-02-27
US20090226470A12009-09-10
US20130177581A12013-07-11
US20090093049A12009-04-09
EP2610341A12013-07-03
EP2610340A12013-07-03
Other References:
SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL, 2001
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, 2003
BUNDGARD, H.: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-24
HIGUCHI, T. ET AL.: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
WELLENSIEK ET AL.: "Genome-wide profiling of human cap-independent translation-enhancing elements", NATURE METHODS, vol. 10, no. 8, August 2013 (2013-08-01), pages 747 - 750, XP055658496, DOI: 10.1038/nmeth.2522
CHAPPELL ET AL., PNAS, vol. 101, no. 26, 29 June 2004 (2004-06-29), pages 9590 - 9594
PANEK ET AL., NUCLEIC ACIDS RESEARCH, vol. 41, 1 September 2013 (2013-09-01), pages 7625 - 7634
ANTIBODY ENGINEERING, 1995
KUBY, IMMUNOLOGY, 1997
HARLOWLANE, ANTIBODIES: A LABORATORY MANUAL, 1989
"Mol. Biology and Biotechnology: A Comprehensive Desk Reference", 1995
HUSTON ET AL., CELL BIOPHYSICS, vol. 22, 1993, pages 189 - 224
PLIICKTHUNSKERRA, METH. ENZYMOL., vol. 178, 1989, pages 497 - 515
DAY, ADVANCED IMMUNOCHEMISTRY, 1990
PHYSICIAN'S DESK REFERENCE, 2014
SABNIS ET AL.: "A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates", MOLECULAR THERAPY, vol. 26, no. 6, 2018, XP055644778, DOI: 10.1016/j.ymthe.2018.03.010
KORE ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 4570 - 4574
CHAPPELL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 9590 - 9594
ZHOU ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 6273 - 6278
KEDDE ET AL.: "A Pumilio-induced RNA structure switch in p27-3'UTR controls miR-221 and miR-222 accessibility", NAT CELL BIOL., vol. 12, no. 10, October 2010 (2010-10-01), pages 1014 - 20
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: ANTI-FGFR2 ADCC ENHANCED ANTIBODY AND USE THEREOF

Next Patent: FALSE NEGATIVE SAMPLE RECOGNITION-BASED PHYSICAL EXAMINATION ASSISTANT DECISION-MAKING SYSTEM