LIPID NANOPARTICLES USING CATIONIC CHOLESTEROL FOR LOCAL DELIVERY FOR NUCLEIC ACID DELIVERY

WIPO Patent Application WO/2024/010330

A1

The present invention is directed to lipid nanoparticles using cationic cholesterol for topical delivery for nucleic acid delivery, and when administered locally, side effects caused by systemic drug delivery can be minimized and protein expression can be confined to the site of administration. In addition, the duration of protein expression at the site of administration can be increased, and thus the lipid nanoparticles can be useful in the technical field related to nucleic acid therapeutics.

WO/2019/119170	BIODEGRADABLE BIOCOMPATIBLE NANOPARTICLES LOADED WITH AN ACTIVE DRUG SELECTED FROM ADENOSINE TRIPHOSPHATE (ATP), AND COATED WITH BIOLOGICAL MEMBRANES SELECTED FROM ERYTHROCYTE MEMBRANES AND COMPOSITION CONTAINING SAID NANOPARTICLES, WHICH ARE USEFUL IN CANCER TREATMENT
JP2001500109	INDUSTRIAL APPLICABILITY A composition suitable for delivery of a gene to epithelial cells.
JP2023168654	COMPOSITE POROUS MATERIAL OF ANTICANCER DRUG-CONTAINING LIPOSOME, PHOTOTHERMAL CONVERSION NANOPARTICLE AND BIOABSORBABLE POLYMER AND METHOD FOR PRODUCING THE SAME

PARK JOON YOUNG (KR)
SON JIYEON (KR)
NAM HYO JUNG (KR)
LEE JUNG-EUN (KR)

PCT/KR2023/009400

January 11, 2024

July 04, 2023

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GREEN CROSS CORP (KR)

A61K9/51; A61K9/00; A61K31/7088; A61K47/18; A61K47/22; A61K47/24; A61K47/28; A61K48/00; C12N15/88

WO2020219941A1	2020-10-29
WO2011140627A1	2011-11-17

OBERLI, M. A. ET AL.: "Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy", NANO LETTERS, vol. 17, 2017, pages 1326 - 1335, XP055614115, DOI: 10.1021/acs.nanolett.6b03329
YANG SHUO-YE, ZHENG YI, CHEN JIA-YIN, ZHANG QIU-YANG, ZHAO DI, HAN DE-EN, CHEN XI-JING: "Comprehensive study of cationic liposomes composed of DC-Chol and cholesterol with different mole ratios for gene transfection", COLLOIDS AND SURFACES B: BIOINTERFACES, ELSEVIER AMSTERDAM, NL, vol. 101, 1 January 2013 (2013-01-01), NL , pages 6 - 13, XP093126362, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2012.05.032
KIM M., JEONG M, HUR S, CHO Y, PARK J, JUNG H, SEO Y, WOO H A, NAM K T, LEE K, LEE H, : "Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver", SCIENCE ADVANCES, vol. 7, 26 February 2021 (2021-02-26), pages eabf4398, XP093126364

LEE, Cheo Young et al. (KR)

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