Title:
LIPID NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2024/053648
Kind Code:
A1
Abstract:
The present invention provides candidate molecules for constituent components of various lipid nanoparticles. The present invention pertains to a C-glycoside glycolipid compound represented by formula (I) or formula (II), a lipid nanoparticle containing the same, and a pharmaceutical composition containing the lipid nanoparticles, particularly a vaccine.
Inventors:
HIRAI GO (JP)
MATSUNAGA NAOYA (JP)
YORITATE MAKOTO (JP)
OHDO SHIGEHIRO (JP)
KONDO HIROSATO (JP)
MATSUNAGA NAOYA (JP)
YORITATE MAKOTO (JP)
OHDO SHIGEHIRO (JP)
KONDO HIROSATO (JP)
Application Number:
PCT/JP2023/032416
Publication Date:
March 14, 2024
Filing Date:
September 05, 2023
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
C07D309/10; A61K9/16; A61K39/00; A61K47/10; A61K47/22; A61K47/26; A61P37/04; C07H17/04; C12N5/10; C12N15/11; C12N15/88
Foreign References:
| JP2001354666A | 2001-12-25 | |||
| US20050192248A1 | 2005-09-01 | |||
| US20130164325A1 | 2013-06-27 |
Other References:
GARG, H. ; FRANCELLA, N. ; TONY, K.A. ; AUGUSTINE, L.A. ; BARCHI, J.J. ; FANTINI, J. ; PURI, A. ; MOOTOO, D.R. ; BLUMENTHAL, R.: "Glycoside analogs of @b-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 80, no. 1, 1 October 2008 (2008-10-01), NL , pages 54 - 61, XP024339830, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2008.04.004
CIPOLLA, L. NICOTRA*, F. VISMARA, E. GUERRINI, M.: "Synthesis of Stable Analogues of Glyceroglycolipids", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 17, 1 April 1997 (1997-04-01), AMSTERDAM, NL , pages 6163 - 6170, XP004105839, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(97)00273-1
POSTEMA MAARTEN H. D., PIPER JARED L.: "Synthesis of Some Biologically Relevant β- C -Glycoconjugates", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 10, 1 May 2003 (2003-05-01), US , pages 1721 - 1723, XP093147976, ISSN: 1523-7060, DOI: 10.1021/ol034363q
AUGUSTIN, L.A. FANTINI, J. MOOTOO, D.R.: "C-Glycoside analogues of @b-galactosylceramide with a simple ceramide substitute: Synthesis and binding to HIV-1 gp120", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 4, 15 February 2006 (2006-02-15), AMSTERDAM, NL, pages 1182 - 1188, XP005237573, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2005.09.044
KOPEčNá MONIKA; MACHáčEK MILOSLAV; PRCHALOVá EVA; ŠTěPáNEK PETR; DRAšAR PAVEL; KOTORA: "Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery", ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 34, no. 10, 29 June 2017 (2017-06-29), Berlin/Heidelberg, pages 2097 - 2108, XP036310020, ISSN: 0724-8741, DOI: 10.1007/s11095-017-2214-3
CIPOLLA, L. NICOTRA*, F. VISMARA, E. GUERRINI, M.: "Synthesis of Stable Analogues of Glyceroglycolipids", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 53, no. 17, 1 April 1997 (1997-04-01), AMSTERDAM, NL , pages 6163 - 6170, XP004105839, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(97)00273-1
POSTEMA MAARTEN H. D., PIPER JARED L.: "Synthesis of Some Biologically Relevant β- C -Glycoconjugates", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 10, 1 May 2003 (2003-05-01), US , pages 1721 - 1723, XP093147976, ISSN: 1523-7060, DOI: 10.1021/ol034363q
AUGUSTIN, L.A. FANTINI, J. MOOTOO, D.R.: "C-Glycoside analogues of @b-galactosylceramide with a simple ceramide substitute: Synthesis and binding to HIV-1 gp120", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 14, no. 4, 15 February 2006 (2006-02-15), AMSTERDAM, NL, pages 1182 - 1188, XP005237573, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2005.09.044
KOPEčNá MONIKA; MACHáčEK MILOSLAV; PRCHALOVá EVA; ŠTěPáNEK PETR; DRAšAR PAVEL; KOTORA: "Galactosyl Pentadecene Reversibly Enhances Transdermal and Topical Drug Delivery", ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 34, no. 10, 29 June 2017 (2017-06-29), Berlin/Heidelberg, pages 2097 - 2108, XP036310020, ISSN: 0724-8741, DOI: 10.1007/s11095-017-2214-3
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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