Title:
LIPOCALIN-TYPE PROSTAGLANDIN D2 SYNTHASE PRODUCTION ACCELERATING AGENT
Document Type and Number:
WIPO Patent Application WO/2019/131879
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a lipocalin-type prostaglandin D2 synthase (L-PGDS) production accelerating agent, more specifically, an L-PGDS production accelerating agent in pericytes or ischemia-induced multipotent stem cells (iSC) de-differentiated from pericytes. The present invention has verified that a substance having an L-PGDS production accelerating effect is contained in an extract of inflammatory tissues inoculated with vaccinia virus. The L-PGDS production accelerating agent according to the present invention is highly useful as a drug or the like for prevention, treatment, or relapse prevention of disorders on which the enhanced expression of L-PGDS is expected to be effective, more specifically, cerebral vascular disorders such as brain infarction, dementia such as Alzheimer's disease, or sleep disorder.
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Inventors:
MATSUYAMA TOMOHIRO (JP)
NAKAGOMI TAKAYUKI (JP)
FUKUDA YU (JP)
NAKAGOMI TAKAYUKI (JP)
FUKUDA YU (JP)
Application Number:
PCT/JP2018/048141
Publication Date:
July 04, 2019
Filing Date:
December 27, 2018
Export Citation:
Assignee:
HYOGO COLLEGE MEDICINE (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
International Classes:
A61K45/00; A61K35/36; A61P9/10; A61P25/20; A61P25/28; A61P43/00; C12Q1/6844; G01N33/15; G01N33/50
Domestic Patent References:
| WO2011162317A1 | 2011-12-29 |
Foreign References:
| JP2007284351A | 2007-11-01 | |||
| JP2000016942A | 2000-01-18 | |||
| JP2012508192A | 2012-04-05 | |||
| JPS6479657A | 1989-03-24 | |||
| JP2001103869A | 2001-04-17 | |||
| JP2014076961A | 2014-05-01 | |||
| JP2000016942A | 2000-01-18 | |||
| JP3818657B2 | 2006-09-06 | |||
| JP4883798B2 | 2012-02-22 |
Other References:
GARCIA-FERNANDEZ LF ET AL.: "Dexamethasone induces lipocalin-type prostaglandin D synthase gene expression in mouse neuronal cells", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 2, 2000, pages 460 - 470, XP55622513, ISSN: 0022-3042
KIMURA, HIROSHI ET AL.: "A pilot study for clinical application of Neurotropin to senile patients with dementia", JAPANESE PHARMACOLOGY & THERAPEUTICS, vol. 15, no. 10, October 1987 (1987-10-01), pages 4235 - 4251, XP009521902, ISSN: 0386-3603
SALEEM S ET AL.: "Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia", NEUROSCIENCE, vol. 160, no. 1, 2009, pages 248 - 254, XP026036090, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2009.02.039
KANEKIYO T ET AL.: "Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 15, 10 April 2007 (2007-04-10), pages 6412 - 6417, XP55622522, ISSN: 0027-8424
INUI T. ET AL., J. CEREB. BLOOD FLOW METAB., vol. 34, 2014, pages 1558 - 1567
KANEKIYO T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 104, 2007, pages 6412 - 6417
TANIGICHI H. ET AL., J. NEUROSCI., vol. 27, 2007, pages 4303 - 4312
SALEEM S. ET AL., NEUROSCIENCE, vol. 160, 2009, pages 248 - 254
TANIIKE M. ET AL., J. NEUROSCI., vol. 22, 2002, pages 4885 - 4896
TRIMARCO A. ET AL., NATURE NEUROSCI., vol. 17, 2014, pages 1682 - 1992
ABDO H. ET AL., J. PHYSIOL., vol. 590, 2012, pages 2739 - 2750
UENO R. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 109, 1982, pages 576 - 582
URADE Y.HAYAISHI O., BIOCHIM. BIOPHYS. ACTA, vol. 1482, 2000, pages 259 - 271
NAKAGOMI, T. ET AL., EUR. J. NEUROSCI., vol. 29, 2009, pages 1842 - 1852
URADE Y. ET AL., J LIPID MEDIAT. CELL SIGNAL., vol. 14, 1996, pages 71 - 82
TATEBAYASHI K. ET AL., STEM CELLS AND DEVELOP., vol. 26, 2017, pages 787 - 797
See also references of EP 3733205A4
KIMURA, HIROSHI ET AL.: "A pilot study for clinical application of Neurotropin to senile patients with dementia", JAPANESE PHARMACOLOGY & THERAPEUTICS, vol. 15, no. 10, October 1987 (1987-10-01), pages 4235 - 4251, XP009521902, ISSN: 0386-3603
SALEEM S ET AL.: "Lipocalin-prostaglandin D synthase is a critical beneficial factor in transient and permanent focal cerebral ischemia", NEUROSCIENCE, vol. 160, no. 1, 2009, pages 248 - 254, XP026036090, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2009.02.039
KANEKIYO T ET AL.: "Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 104, no. 15, 10 April 2007 (2007-04-10), pages 6412 - 6417, XP55622522, ISSN: 0027-8424
INUI T. ET AL., J. CEREB. BLOOD FLOW METAB., vol. 34, 2014, pages 1558 - 1567
KANEKIYO T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 104, 2007, pages 6412 - 6417
TANIGICHI H. ET AL., J. NEUROSCI., vol. 27, 2007, pages 4303 - 4312
SALEEM S. ET AL., NEUROSCIENCE, vol. 160, 2009, pages 248 - 254
TANIIKE M. ET AL., J. NEUROSCI., vol. 22, 2002, pages 4885 - 4896
TRIMARCO A. ET AL., NATURE NEUROSCI., vol. 17, 2014, pages 1682 - 1992
ABDO H. ET AL., J. PHYSIOL., vol. 590, 2012, pages 2739 - 2750
UENO R. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 109, 1982, pages 576 - 582
URADE Y.HAYAISHI O., BIOCHIM. BIOPHYS. ACTA, vol. 1482, 2000, pages 259 - 271
NAKAGOMI, T. ET AL., EUR. J. NEUROSCI., vol. 29, 2009, pages 1842 - 1852
URADE Y. ET AL., J LIPID MEDIAT. CELL SIGNAL., vol. 14, 1996, pages 71 - 82
TATEBAYASHI K. ET AL., STEM CELLS AND DEVELOP., vol. 26, 2017, pages 787 - 797
See also references of EP 3733205A4
Attorney, Agent or Firm:
FUJII, Ikuro (JP)
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