Title:
LIPOSOMAL VECTORS
Document Type and Number:
WIPO Patent Application WO2006031471
Kind Code:
A3
Abstract:
The present invention provides for liposomal vectors which inhibit inflammation and/or enhance expression of transferred genes. It is based, at least in part, of the discovery that vectors comprising a nucleic acid carrying a gene of interest and a cationic liposome containing an immunosuppressive agent induce lower levels of inflammatory cytokine relative to conventional lipoplex vectors, as well as on the discovery that a component may be incorporated into the liposome which enhances expression of the gene of interest.
Inventors:
HUANG LEAF (US)
LIU FENG (US)
LIU FENG (US)
Application Number:
PCT/US2005/031373
Publication Date:
June 22, 2006
Filing Date:
September 01, 2005
Export Citation:
Assignee:
M OF HIGHER EDUCATION UNIVERSI (US)
HUANG LEAF (US)
LIU FENG (US)
HUANG LEAF (US)
LIU FENG (US)
International Classes:
A61K31/70; A01N43/04; A61K36/37
Other References:
WHITMORE ET AL: "lipopolyplex initiates a potent cytokine response and inhibits tumor growth", GENE THERAPY, 1999, pages 1867 - 1875
TEGEDER ET AL: "Cyclooxygenase-independent actions of cyclooxygenase inhibitors", FASEB J., 2001, pages 2057 - 2072
KAGOSHIMA ET AL: "Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, 2003, pages 60 - 65
CHOI ET AL: "Anti-inflammatory effects of fangchinoline and tetrandrine", JOURNAL OF ETHNOPHARMACOLOGY, 2000, pages 173 - 179
TEGEDER ET AL: "Cyclooxygenase-independent actions of cyclooxygenase inhibitors", FASEB J., 2001, pages 2057 - 2072
KAGOSHIMA ET AL: "Glucocorticoid suppression of nuclear factor-kappa B: a role for histone modifications", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 31, 2003, pages 60 - 65
CHOI ET AL: "Anti-inflammatory effects of fangchinoline and tetrandrine", JOURNAL OF ETHNOPHARMACOLOGY, 2000, pages 173 - 179
Download PDF: