Title:
LIPOSOME COMPOSITION AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2015/166986
Kind Code:
A1
Abstract:
The present invention addresses the issue of providing: a liposome composition having long-term storage stability as required for practical application that, by making the internal aqueous phase thereof hypertonic, is capable of suitably adjusting drug release properties and has a drug release speed in the order of several tens of hours; and a production method therefor. As a result of the present invention, a liposome composition is provided that has: a liposome having an internal aqueous phase; and an aqueous solution that disperses liposomes constituting an external aqueous phase. The liposome composition has a cholesterol content of 10-35 mol% relative to the total lipid component of the liposome composition; the liposome contains a drug in a dissolved state; and the osmotic pressure of the internal aqueous phase is 2-8 times the osmotic pressure of the external aqueous phase.
Inventors:
OHNO MAKOTO (JP)
ONO KOUHEI (JP)
MATSUMOTO TAKESHI (JP)
MORI MIKINAGA (JP)
ONO KOUHEI (JP)
MATSUMOTO TAKESHI (JP)
MORI MIKINAGA (JP)
Application Number:
PCT/JP2015/062983
Publication Date:
November 05, 2015
Filing Date:
April 30, 2015
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
A61K9/127; A61K47/24; A61K47/28; B01J13/02; B01J13/20
Foreign References:
| JP2005509000A | 2005-04-07 | |||
| JP2007536247A | 2007-12-13 | |||
| JP2013508315A | 2013-03-07 | |||
| JP2013126953A | 2013-06-27 |
Other References:
See also references of EP 3138555A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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