Title:
LIPOSOME ENCAPSULATING AMMINE-PLATINUM COMPLEX AT HIGH CONCENTRATION, AND METHOD FOR PRODUCTION OF THE LIPOSOME
Document Type and Number:
WIPO Patent Application WO/2008/072584
Kind Code:
A1
Abstract:
Disclosed is a method for producing a liposome encapsulating an ammine-platinum complex. The method comprises the steps of: A) providing a water-soluble ammine-platinum complex, a platinum complex raw material or a combination thereof; B) providing a liposome, a liposome raw material or a combination thereof; and C) preparing a mixture of the water-soluble ammine-platinum complex, the platinum complex raw material or the combination thereof and the liposome, the liposome raw material or the combination thereof and subjecting the mixture under the conditions where a liposome can be formed and maintained, wherein a salt formed by the platinum complex is in a water-soluble form at the time point where the liposome exists.
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Inventors:
HIRAI MASAHIKO (JP)
IGARASHI KOICHI (JP)
CHIKUMA MASAHIKO (JP)
OIE KAZUNORI (JP)
IGARASHI KOICHI (JP)
CHIKUMA MASAHIKO (JP)
OIE KAZUNORI (JP)
Application Number:
PCT/JP2007/073727
Publication Date:
June 19, 2008
Filing Date:
December 07, 2007
Export Citation:
Assignee:
KATAYAMA CHEMICAL IND CO LTD (JP)
HIRAI MASAHIKO (JP)
IGARASHI KOICHI (JP)
CHIKUMA MASAHIKO (JP)
OIE KAZUNORI (JP)
HIRAI MASAHIKO (JP)
IGARASHI KOICHI (JP)
CHIKUMA MASAHIKO (JP)
OIE KAZUNORI (JP)
International Classes:
A61K31/282; A61K9/127; A61K33/243; A61K47/02; A61K47/20; A61K47/22; A61K47/24; A61K47/28; A61P35/00
Domestic Patent References:
WO2005053643A1 | 2005-06-16 | |||
WO2005089448A2 | 2005-09-29 |
Foreign References:
JPH05255070A | 1993-10-05 | |||
JP2006502233A | 2006-01-19 | |||
JPH04346918A | 1992-12-02 | |||
JP2003226638A | 2003-08-12 | |||
US20050019755A1 | 2005-01-27 | |||
JPS5654233A | 1981-05-14 | |||
JPS57123198A | 1982-07-31 |
Other References:
NEWMAN M.S. ET AL.: "Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor-bearing mice", CANCER CHEMOTHER. PHARMACOL., vol. 43, no. 1, 1999, pages 1 - 7, XP001018172
MICHAEL J.C. ET AL.: "Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes", BIOORGANIC CHEMISTRY, vol. 2, no. 3, 1973, pages 187 - 210, XP009009169
H. KIKUCHI; N. SUZUKI ET AL., BIOPHARM. DRUG DISPOS., vol. 17, 1999, pages 589 - 605
N. YAMAZAKI; M. KODAMA; H-J. GABIUS, METHODS ENZYMOL., vol. 242, 1994, pages 56 - 65
N. YAMAZAKI, J. MEMBR. SCI., vol. 41, 1989, pages 249 - 267
M. HIRAI ET AL., BBRC, vol. 353, 2007, pages 553 - 558
S. G. DHARA, INDIAN J. CHEM., vol. 7, 1970, pages 335
A. A. GABIZON, CANCER RES., vol. 52, 1992, pages 891 - 896
S. K. HUANG; F. J. MARTIN; G. JAY ET AL., AM. J. PATHOL., vol. 143, 1993, pages 10 - 14
S. K. HUANG; E. MAYHEW; S. GILANI ET AL., CANCER RES., vol. 52, 1992, pages 6774 - 6781
N. Z. WU; D. DA; T. L. RUDOLL ET AL., CANCER RES., vol. 53, 1993, pages 3765 - 3770
J. D. ALMEIDA ET AL., LANCET, vol. 2, no. 7941, 1975, pages 899 - 901
Y. MATSUMURA; H. MAEDA, CANCER RES., vol. 46, 1986, pages 6387 - 6392
B. ROSENBERG, BIOCHIMIE, 1978, pages 60859
"NTS", 2005, article "New development in liposome Application -For development of an artificial cell", pages: 33 - 45
SHOSHICHI NOJIMA, LIPOSOMES, 1988, pages 21 - 40
R. FRAGGIANI ET AL., J. AM. CHEM. SOC., vol. 99, 1977, pages 777
F. D. ROCHON; A. MORNEAU; R. MELASON, INORG. CHEM., vol. 27, 1988, pages 10
YAMAZAKI, N.; KODAMA, M.; GABIUS, H.-J., METHODS ENZYMOL., vol. 242, 1994, pages 56 - 65
CANCER CHEMOTHER. PHARMACOL., vol. 43, 1999, pages 1 - 7
MARY S. NEWMAN; GAIL T. COLBERN; PETER K. WORKING ET AL.: "Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposome (SPI-077) in tumor-bearing mice", CANCER CHEMOTHER. PHARMACOL., vol. 43, 1999, pages 1 - 7, XP001018172, DOI: doi:10.1007/s002800050855
See also references of EP 2090305A4
MICHAEL J.C. ET AL.: "Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes", BIOORGANIC CHEMISTRY, vol. 2, no. 3, 1973, pages 187 - 210, XP009009169
H. KIKUCHI; N. SUZUKI ET AL., BIOPHARM. DRUG DISPOS., vol. 17, 1999, pages 589 - 605
N. YAMAZAKI; M. KODAMA; H-J. GABIUS, METHODS ENZYMOL., vol. 242, 1994, pages 56 - 65
N. YAMAZAKI, J. MEMBR. SCI., vol. 41, 1989, pages 249 - 267
M. HIRAI ET AL., BBRC, vol. 353, 2007, pages 553 - 558
S. G. DHARA, INDIAN J. CHEM., vol. 7, 1970, pages 335
A. A. GABIZON, CANCER RES., vol. 52, 1992, pages 891 - 896
S. K. HUANG; F. J. MARTIN; G. JAY ET AL., AM. J. PATHOL., vol. 143, 1993, pages 10 - 14
S. K. HUANG; E. MAYHEW; S. GILANI ET AL., CANCER RES., vol. 52, 1992, pages 6774 - 6781
N. Z. WU; D. DA; T. L. RUDOLL ET AL., CANCER RES., vol. 53, 1993, pages 3765 - 3770
J. D. ALMEIDA ET AL., LANCET, vol. 2, no. 7941, 1975, pages 899 - 901
Y. MATSUMURA; H. MAEDA, CANCER RES., vol. 46, 1986, pages 6387 - 6392
B. ROSENBERG, BIOCHIMIE, 1978, pages 60859
"NTS", 2005, article "New development in liposome Application -For development of an artificial cell", pages: 33 - 45
SHOSHICHI NOJIMA, LIPOSOMES, 1988, pages 21 - 40
R. FRAGGIANI ET AL., J. AM. CHEM. SOC., vol. 99, 1977, pages 777
F. D. ROCHON; A. MORNEAU; R. MELASON, INORG. CHEM., vol. 27, 1988, pages 10
YAMAZAKI, N.; KODAMA, M.; GABIUS, H.-J., METHODS ENZYMOL., vol. 242, 1994, pages 56 - 65
CANCER CHEMOTHER. PHARMACOL., vol. 43, 1999, pages 1 - 7
MARY S. NEWMAN; GAIL T. COLBERN; PETER K. WORKING ET AL.: "Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposome (SPI-077) in tumor-bearing mice", CANCER CHEMOTHER. PHARMACOL., vol. 43, 1999, pages 1 - 7, XP001018172, DOI: doi:10.1007/s002800050855
See also references of EP 2090305A4
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (Crystal Tower2-27, Shiromi 1-chome,Chuo-ku, Osaka-shi, Osaka 15, JP)
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