LIPOSOME MANUFACTURING DEVICE

WIPO Patent Application WO/2010/041727

A1

Provided is a liposome manufacturing device which is a relatively small, multipurpose liposome manufacturing device that uses a motor, and that can reliably manufacture various types of liposomes and reconfigured liposomes. The multipurpose liposome manufacturing device is provided with an eccentric motor (3) that generates a vortex flow in a solution held inside a reaction space (2A), a heater (15), an aqueous solution line (6A) that can introduce an aqueous solution into the reaction space, a first bottle (9) that holds the aqueous solution, a first pump (14A) that moves the aqueous solution, an inert gas line (7B) that can introduce nitrogen gas into the reaction space, a decompression line (7B) that decompresses the reaction space, a vacuum pump (21) that decompresses the decompression line, a lipid line (6B) that can introduce an organic solvent in which a lipid is dissolved into the reaction space, a second bottle (10) that holds the organic solvent, and a second pump (14B) that moves the organic solvent to the reaction space through the lipid line (6B). The inert gas is introduced into a reaction vessel (2), the motor (3) is driven, and inside the reaction space (2A), while a vortex flow is generated in the organic solvent in which the lipid held in the reaction space (2A) is dissolved, the vacuum pump (21) is driven, the reaction space (2A) is decompressed to gasify the organic solvent from the reaction space (2A), and a thin lipid film is prepared on the inside wall of the reaction vessel (2). The inert gas is then introduced into the reaction space (2A), and the aqueous solution is added to the thin lipid film, the motor (3) is driven to generate a vortex flow in the aqueous solution, and liposomes are produced.

YOSHIMURA TETSURO (JP)
TSUMOTO KANTA (JP)
HASHIMOTO MASATOSHI (JP)
YAMAGATA TOSHIHIKO (JP)
AOKI KUNITATE (JP)

PCT/JP2009/067596

April 15, 2010

October 09, 2009

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LIPOSOME ENGINEERING LAB INC (JP)
HASHIMOTO ELECTRONIC INDUSTRY (JP)
B E MARUBISHI CO LTD (JP)
ANABI ESU ESU CO LTD (JP)
YOSHIMURA TETSURO (JP)
TSUMOTO KANTA (JP)
HASHIMOTO MASATOSHI (JP)
YAMAGATA TOSHIHIKO (JP)
AOKI KUNITATE (JP)

B01J13/04; A61J3/07

JPS60502205A	1985-12-19
JP2007245148A	2007-09-27
JPH03504382A	1991-09-26
JP2006512102A	2006-04-13

KOBAYASHI, YOUHEI (JP)
Yohei Kobayashi (JP)

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