Title:
LIPOSOMES CONTAINING PHOSPHORYLATED TAU PEPTIDES FOR INDUCING SUSTAINED IMMUNE RESPONSES
Document Type and Number:
WIPO Patent Application WO/2023/019241
Kind Code:
A3
Abstract:
Methods for inducing a sustained immune response against phosphorylated Tau in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist, a helper T-cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain the sustained immune response.
Inventors:
PFEIFER ANDREA (CH)
MUHS ANDREAS (CH)
GALPERN WENDY (US)
MUHS ANDREAS (CH)
GALPERN WENDY (US)
Application Number:
PCT/US2022/074902
Publication Date:
March 23, 2023
Filing Date:
August 12, 2022
Export Citation:
Assignee:
JANSSEN PHARMACEUTICALS INC (US)
AC IMMUNE SA (CH)
AC IMMUNE SA (CH)
International Classes:
A61K39/39; A61P25/28
Foreign References:
| US20200253873A1 | 2020-08-13 | |||
| US8748386B2 | 2014-06-10 |
Attorney, Agent or Firm:
ICE MILLER LLP et al. (US)
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