Title:
LIQUID PREPARATION FOR ORAL ADMINISTRATION FOR USE IN CT COLONOGRAPHY, AND COMPOSITION FOR IMAGING DIGESTIVE TRACT
Document Type and Number:
WIPO Patent Application WO/2014/073643
Kind Code:
A1
Abstract:
Provided are: a liquid preparation for oral administration, which contains barium that can be mixed with residues readily and is rarely precipitated in the intestinal tract; and a liquid preparation for oral administration and a composition for imaging the digestive tract, each of which contains barium and enables the reduction of the dosage of an intestinal tract washing solution in a pretreatment of the intestinal tract. That is, provided are: a liquid preparation for oral administration, which comprises barium and at least one thickening agent selected from the group consisting of a naturally-occurring polysaccharide and a cellulose-type polymer, and has a viscosity of 100 mPa·s or more at a shear rate of 21.54 s-1 and 5 to 90 mPa·s at a shear rate of 464.1 s-1, wherein barium has such a volume cumulative distribution that the particle diameter D10 is 0.30 to 0.80 μm and the particle diameter D90 is 1.0 to 10 μm; and a liquid preparation for oral administration for use in the imaging of the digestive tract by CT colonography, which comprises barium and a water-soluble polymer or a salt-type purgative agent and is to be administered in an amount of 50 to 2000 mL in a single dose or several divided doses on the day before carrying out the CT colonography.
Inventors:
TAKEDA DENNAI (JP)
FUJIWARA TAKAYUKI (JP)
ANDO NOBUO (JP)
WATANABE TOMOKO (JP)
YOSHINO AKIRA (JP)
FUJIWARA TAKAYUKI (JP)
ANDO NOBUO (JP)
WATANABE TOMOKO (JP)
YOSHINO AKIRA (JP)
Application Number:
PCT/JP2013/080254
Publication Date:
May 15, 2014
Filing Date:
November 08, 2013
Export Citation:
Assignee:
AJINOMOTO KK (JP)
FUSHIMI PHARMACEUTICAL CO LTD (JP)
FUSHIMI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K49/04
Domestic Patent References:
| WO2012046847A1 | 2012-04-12 |
Foreign References:
| JP2010077159A | 2010-04-08 | |||
| JP2002053496A | 2002-02-19 |
Other References:
LEFERE,F.A. ET AL.: "Dietary Fecal Tagging as a Cleansing Method before CT Colonography: Initial Results - Polyp Detection and Patient Acceptance", RADIOLOGY, no. 224, 2, August 2002 (2002-08-01), pages 393 - 403
KIM,M.J. ET AL.: "Efficacy of Barium-Based Fecal Tagging for CT Colonography: a Comparison between the Use of High and Low Density Barium Suspensions in a Korean Population - a Preliminary Study", KOR. J. RADIOL., vol. 10, no. 1, February 2009 (2009-02-01), pages 25 - 33
TAMAKI ICHIKAWA: "III CT Colonography ni Okeru Zenshochiho no Doko ''2. Tagging Zenshochiho - Barium o Shiyo shita fecal tagging o Chushin ni''", INNERVISION, vol. 25, no. 3, March 2010 (2010-03-01), pages 19 - 22
TAMAKI ICHIKAWA ET AL.: "Atarashii Shoka Gazo Shindan ''3 CT colonogeraphy no Aratana Shindan Gijutsu (1) - Zenshochi (fecal tagging & electronic cleansing)''", CLINICAL GASTROENTEROLOGY, vol. 25, no. 7, May 2010 (2010-05-01), pages 890 - 895
KIM,M.J. ET AL.: "Efficacy of Barium-Based Fecal Tagging for CT Colonography: a Comparison between the Use of High and Low Density Barium Suspensions in a Korean Population - a Preliminary Study", KOR. J. RADIOL., vol. 10, no. 1, February 2009 (2009-02-01), pages 25 - 33
TAMAKI ICHIKAWA: "III CT Colonography ni Okeru Zenshochiho no Doko ''2. Tagging Zenshochiho - Barium o Shiyo shita fecal tagging o Chushin ni''", INNERVISION, vol. 25, no. 3, March 2010 (2010-03-01), pages 19 - 22
TAMAKI ICHIKAWA ET AL.: "Atarashii Shoka Gazo Shindan ''3 CT colonogeraphy no Aratana Shindan Gijutsu (1) - Zenshochi (fecal tagging & electronic cleansing)''", CLINICAL GASTROENTEROLOGY, vol. 25, no. 7, May 2010 (2010-05-01), pages 890 - 895
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
Masatake Shiga (JP)
Masatake Shiga (JP)
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