Title:
LISTERIA-BASED ADJUVANTS
Document Type and Number:
WIPO Patent Application WO/2016/126876
Kind Code:
A3
Abstract:
This disclosure provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject. In certain instances, methods of this disclosure may be useful for subjects receiving a transplant.
Inventors:
PETIT ROBERT (US)
Application Number:
PCT/US2016/016452
Publication Date:
October 27, 2016
Filing Date:
February 03, 2016
Export Citation:
Assignee:
ADVAXIS INC (US)
International Classes:
A61K39/39; A61K35/74; A61K39/02; A61K48/00; C07K14/195; C12N9/10; C12N9/16; C12N9/88; C12N15/74
Other References:
ROBACK, J. D.: "Vaccine-enhanced donor lymphocyte infusion (veDLI).", ASH EDUCATION PROGRAM BOOK, vol. 2006, no. 1, 2006, pages 486 - 491, XP055324970
ALPDOGAN, 0. ET AL.: "Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.", BLOOD, vol. 105, no. 2, 2005, pages 865 - 873, XP002604499
ZAKRZEWSKI, J. L. ET AL.: "Adoptive transfer of T- cell precursors enhances T- cell reconstitution after allogeneic hematopoietic stem cell transplantation.", NATURE MEDICINE, vol. 12, no. 9, 2006, pages 1039 - 1047, XP055324976
SEGGEWISS, R. ET AL.: "Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update.", vol. 115, no. 19, 2010, pages 3861 - 3868, XP055324979
MACIAG, P. C. ET AL.: "The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix.", VACCINE, vol. 27, no. 30, 2009, pages 3975 - 3983, XP026153147
ALPDOGAN, 0. ET AL.: "Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.", BLOOD, vol. 105, no. 2, 2005, pages 865 - 873, XP002604499
ZAKRZEWSKI, J. L. ET AL.: "Adoptive transfer of T- cell precursors enhances T- cell reconstitution after allogeneic hematopoietic stem cell transplantation.", NATURE MEDICINE, vol. 12, no. 9, 2006, pages 1039 - 1047, XP055324976
SEGGEWISS, R. ET AL.: "Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update.", vol. 115, no. 19, 2010, pages 3861 - 3868, XP055324979
MACIAG, P. C. ET AL.: "The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix.", VACCINE, vol. 27, no. 30, 2009, pages 3975 - 3983, XP026153147
Attorney, Agent or Firm:
SCHILLING, Stephen, H. et al. (Bank of America Plaza101 South Tryon Street, Suite 400, Charlotte NC, US)
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