Title:
LIVE GENETICALLY ATTENUATED MALARIA VACCINE
Document Type and Number:
WIPO Patent Application WO2005063991
Kind Code:
A3
Abstract:
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
Inventors:
KAPPE STEFAN H I (US)
MATUSCHEWKI KAI-UWE C (DE)
MUELLER ANN-KRISTIN (DE)
MATUSCHEWKI KAI-UWE C (DE)
MUELLER ANN-KRISTIN (DE)
Application Number:
PCT/US2004/043023
Publication Date:
September 09, 2005
Filing Date:
December 20, 2004
Export Citation:
Assignee:
SEATTLE BIOMEDICAL RES INST (US)
RUPRECHT KARL UNI HEIDELBERG (DE)
KAPPE STEFAN H I (US)
MATUSCHEWKI KAI-UWE C (DE)
MUELLER ANN-KRISTIN (DE)
RUPRECHT KARL UNI HEIDELBERG (DE)
KAPPE STEFAN H I (US)
MATUSCHEWKI KAI-UWE C (DE)
MUELLER ANN-KRISTIN (DE)
International Classes:
A61K39/015; C07K14/445; (IPC1-7): C07K14/445; C12N15/30; A61K39/015
Domestic Patent References:
| WO1995007094A1 | 1995-03-16 |
Other References:
SULTAN ALI A ET AL: "TRAP is necessary for gliding motility and infectivity of Plasmodium sporozoites", CELL, vol. 90, no. 3, 1997, pages 511 - 522, XP002331398, ISSN: 0092-8674
MENARD ROBERT ET AL: "Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes", NATURE (LONDON), vol. 385, no. 6614, 1997, pages 336 - 340, XP002331399, ISSN: 0028-0836
MATUSCHEWSKI KAI ET AL: "Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 44, 1 November 2002 (2002-11-01), pages 41948 - 41953, XP002331400, ISSN: 0021-9258
MENARD R ET AL: "Gene Targeting in Malaria Parasites", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 13, no. 2, October 1997 (1997-10-01), pages 148 - 157, XP004466556, ISSN: 1046-2023
VAN DIJK MELISSA R ET AL: "A central role for P48/45 in malaria parasite male gamete fertility", CELL, vol. 104, no. 1, 12 January 2001 (2001-01-12), pages 153 - 164, XP002331401, ISSN: 0092-8674
MUELLER ANN-KRISTIN ET AL: "Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.", NATURE, vol. 433, no. 7022, 13 January 2005 (2005-01-13), pages 164 - 167, XP002331402, ISSN: 1476-4687
MENARD ROBERT ET AL: "Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes", NATURE (LONDON), vol. 385, no. 6614, 1997, pages 336 - 340, XP002331399, ISSN: 0028-0836
MATUSCHEWSKI KAI ET AL: "Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 44, 1 November 2002 (2002-11-01), pages 41948 - 41953, XP002331400, ISSN: 0021-9258
MENARD R ET AL: "Gene Targeting in Malaria Parasites", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 13, no. 2, October 1997 (1997-10-01), pages 148 - 157, XP004466556, ISSN: 1046-2023
VAN DIJK MELISSA R ET AL: "A central role for P48/45 in malaria parasite male gamete fertility", CELL, vol. 104, no. 1, 12 January 2001 (2001-01-12), pages 153 - 164, XP002331401, ISSN: 0092-8674
MUELLER ANN-KRISTIN ET AL: "Genetically modified Plasmodium parasites as a protective experimental malaria vaccine.", NATURE, vol. 433, no. 7022, 13 January 2005 (2005-01-13), pages 164 - 167, XP002331402, ISSN: 1476-4687
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