Title:
LIVER ENGRAFTING CELLS, ASSAYS, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003000848
Kind Code:
A3
Abstract:
A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.
Inventors:
LAGASSE ERIC (US)
AUSTIN TIMOTHY (US)
AUSTIN TIMOTHY (US)
Application Number:
PCT/US2002/019646
Publication Date:
March 20, 2003
Filing Date:
June 21, 2002
Export Citation:
Assignee:
STEMCELLS INC (US)
LAGASSE ERIC (US)
AUSTIN TIMOTHY (US)
LAGASSE ERIC (US)
AUSTIN TIMOTHY (US)
International Classes:
A01K67/027; A61K35/407; A61P1/16; A61P31/04; A61P31/10; A61P31/14; A61P31/20; A61P33/02; A61P35/00; C12N5/074; C12N5/10; C12Q1/02; C12Q1/68; G01N33/50; A61K35/12; (IPC1-7): C12N5/00; C12N5/08; C12N15/63
Other References:
DATABASE MEDLINE [online] KIM ET AL.: "Differential expression and distribution of focal adhesion and cell adhesion molecules in rat hepatocytes differentiation", XP002958751, Database accession no. 1998:445274
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