Title:
LIVER FIBROSIS INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2002/098405
Kind Code:
A1
Abstract:
Liver fibrosis inhibitors containing cysteine (may be in the form of a salt) wherein cysteine is contained as a sole active ingredient for inhibiting liver fibrosis and the daily dose or intake of cysteine is at least 200 mg, expressed in terms of free compound, in case of oral administration or oral intake. These inhibitors can be taken in the form of drugs or foods or drinks. They are efficacious for liver diseases, in particular, cirrhosis such as compensated cirrhosis. These inhibitors are usable not only as drugs for liver diseases but also as foods and drinks for ameliorating and sustaining liver functions such as foods with health claims, food for patients, etc.
Inventors:
SONAKA ICHIRO (JP)
ISHIZAKI SONOKO (JP)
NAKAJOH MEGUMI (JP)
HORIE TAKASHI (JP)
ISHIZAKI SONOKO (JP)
NAKAJOH MEGUMI (JP)
HORIE TAKASHI (JP)
Application Number:
PCT/JP2002/005328
Publication Date:
December 12, 2002
Filing Date:
May 31, 2002
Export Citation:
Assignee:
AJINOMOTO KK (JP)
SONAKA ICHIRO (JP)
ISHIZAKI SONOKO (JP)
NAKAJOH MEGUMI (JP)
HORIE TAKASHI (JP)
SONAKA ICHIRO (JP)
ISHIZAKI SONOKO (JP)
NAKAJOH MEGUMI (JP)
HORIE TAKASHI (JP)
International Classes:
A61K31/198; A61P1/16; A61P43/00; (IPC1-7): A61K31/198; A61P1/16; A61P43/00
Foreign References:
| JPH02212424A | 1990-08-23 | |||
| JPS57209214A | 1982-12-22 | |||
| JPH09194360A | 1997-07-29 | |||
| JPH041130A | 1992-01-06 | |||
| JPS6354320A | 1988-03-08 | |||
| JP2001089412A | 2001-04-03 | |||
| JPH10330249A | 1998-12-15 | |||
| JPH10330256A | 1998-12-15 | |||
| EP0827742A1 | 1998-03-11 | |||
| JPH09227365A | 1997-09-02 | |||
| JPH0421630A | 1992-01-24 | |||
| EP0323855A2 | 1989-07-12 |
Other References:
CHEMICAL ABSTRACTS, vol. 90, no. 13, 1979, Columbus, Ohio, US; abstract no. 98154J, BACHMANN E. ET AL.: "Rat liver collagen in protracted thioacetamide intoxication. Part 3. Comparative quantitative biochemical and histological investigations (with and without drug influences)" page 102; column 2; XP002954196
Attorney, Agent or Firm:
Ishida, Yasumasa (Bohsei Bldg. 7th Floor, 20-12, Shin-Yokohama
3-chome, Kohoku-k, Yakohama-shi Kanagawa, JP)
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