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Title:
LIVER SPECIFIC DELIVERY-BASED GEMCITABINE PRODRUG NUCLEOSIDE CYCLIC PHOSPHATE COMPOUND, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/120299
Kind Code:
A1
Abstract:
Provided are a liver specific delivery (LSD)-based anticancer prodrug nucleoside cyclic phosphate compound and an application thereof, and in particular, a compound represented by formula (I) as well as isomers, pharmaceutically acceptable salts, hydrates, and solvates thereof, and corresponding pharmaceutical compositions. Also provided is an application of the compound alone or in combination with other anticancer drugs in anticancer area, particularly the treatment of hepatocellular carcinoma (HHC).

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Inventors:
XI ZHIJIAN (CN)
XU HUAQIANG (CN)
LU CHUNPING (CN)
WU ZHONGSHAN (CN)
Application Number:
PCT/CN2018/122821
Publication Date:
June 27, 2019
Filing Date:
December 21, 2018
Export Citation:
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Assignee:
ZHEJIANG PALO ALTO PHARMACEUTICALS INC (CN)
International Classes:
C07H19/11; A61K31/7068; A61P35/00; C07F9/6574; C07H1/00
Domestic Patent References:
WO2009073506A22009-06-11
Foreign References:
CN104211742A2014-12-17
CN101475594A2009-07-08
CN1711278A2005-12-21
CN1733779A2006-02-15
Other References:
See also references of EP 3730508A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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