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Title:
LIVER SPECIFIC DELIVERY-BASED GEMCITABINE PRODRUG NUCLEOSIDE CYCLIC PHOSPHATE COMPOUND, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/120299
Kind Code:
A1
Abstract:
Provided are a liver specific delivery (LSD)-based anticancer prodrug nucleoside cyclic phosphate compound and an application thereof, and in particular, a compound represented by formula (I) as well as isomers, pharmaceutically acceptable salts, hydrates, and solvates thereof, and corresponding pharmaceutical compositions. Also provided is an application of the compound alone or in combination with other anticancer drugs in anticancer area, particularly the treatment of hepatocellular carcinoma (HHC).

Inventors:
XI, Zhijian (Room 301 and 302, Building 1889 Century Avenue, Kecheng Distric, Quzhou Zhejiang 9, 324099, CN)
XU, Huaqiang (Room 301 and 302, Building 1889 Century Avenue, Kecheng Distric, Quzhou Zhejiang 9, 324099, CN)
LU, Chunping (Room 301 and 302, Building 1889 Century Avenue, Kecheng Distric, Quzhou Zhejiang 9, 324099, CN)
WU, Zhongshan (Room 301 and 302, Building 1889 Century Avenue, Kecheng Distric, Quzhou Zhejiang 9, 324099, CN)
Application Number:
CN2018/122821
Publication Date:
June 27, 2019
Filing Date:
December 21, 2018
Export Citation:
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Assignee:
ZHEJIANG PALO ALTO PHARMACEUTICALS, INC. (Room 301 and 302, Building 1889 Century Avenue, Kecheng Distric, Quzhou Zhejiang 9, 324099, CN)
International Classes:
C07H19/11; A61K31/7068; A61P35/00; C07F9/6574; C07H1/00
Domestic Patent References:
WO2009073506A22009-06-11
Foreign References:
CN104211742A2014-12-17
CN101475594A2009-07-08
CN1711278A2005-12-21
CN1733779A2006-02-15
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (Room 106, Building No. 1Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District, Shanghai 3, 200333, CN)
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