LIVER-SPECIFIC TRANSCRIPTIONAL REGULATORY SEQUENCE AND APPLICATIONS THEREOF - RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE

Title:

LIVER-SPECIFIC TRANSCRIPTIONAL REGULATORY SEQUENCE AND APPLICATIONS THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/091457

Kind Code:

A1

Abstract:

Provided is a regulatory sequence for improving specific expression of a downstream gene in liver cells. The regulatory sequence comprises regulatory sequences of albumin and transthyretin, and can specifically express a therapeutic gene in liver cells.

Inventors:

ZHANG LIN (CN)
CHEN SAIJUAN (CN)
WANG QIANG (CN)

Application Number:

PCT/CN2018/114844

Publication Date:

May 16, 2019

Filing Date:

November 09, 2018

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Assignee:

RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE (CN)

International Classes:

C12N15/113; A61K48/00; A61P7/04; C12N15/864

Foreign References:

CN108239645A	2018-07-03
CN101550425A	2009-10-07
CN1670216A	2005-09-21
CN103421793A	2013-12-04

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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