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Title:
LIVING RADICAL POLYMERIZATION INITIATOR COMPRISING A FUNCTIONAL GROUP CAPABLE OF REACTING WITH POLYPEPTIDES OR THE LIKE, COMB POLYMER OBTAINED THEREWITH, POLYPEPTIDE CONJUGATES AND DRUGS OBTAINED THEREFROM
Document Type and Number:
WIPO Patent Application WO2004113394
Kind Code:
A3
Abstract:
The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerisation of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

Inventors:
HADDLETON DAVID (GB)
LECOLLEY FRANCOIS (GB)
TAO LEI (GB)
MANTOVANI GIUSEPPE (GB)
CARMICHAEL ADRIAN (GB)
Application Number:
GB2004002608W
Publication Date:
May 06, 2005
Filing Date:
June 18, 2004
Export Citation:
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Assignee:
WARWICK EFFECT POLYMERS LIMITED
HADDLETON, DAVID
LECOLLEY, FRANCOIS
TAO, LEI
MANTOVANI, GIUSEPPE
CARMICHAEL, ADRIAN
International Classes:
C07D207/404; C07D207/452; C07D209/48; C07D213/70; C07D233/54; C07D249/18; C07D251/26; C07D251/42; C07D491/18; C08F2/38; C08F4/00; C08F290/06; C08F293/00; C08F299/02; C07D207/40; C07D207/44; (IPC1-7): C08F2/38; C08F293/00; C08F299/02; C08F290/06; A61K47/48
Domestic Patent References:
WO1997047661A11997-12-18
WO2003062290A12003-07-31
WO2004063237A12004-07-29
Other References:
HADDLETON, DAVID M. ET AL: "Phenolic ester-based initiators for transition metal mediated living polymerization", MACROMOLECULES , 32(26), 8732-8739 CODEN: MAMOBX; ISSN: 0024-9297, 1999, XP002314659
NARAIN, RAVIN ET AL: "Direct Synthesis and Aqueous Solution Properties of Well-Defined Cyclic Sugar Methacrylate Polymers", MACROMOLECULES , 36(13), 4675-4678 CODEN: MAMOBX; ISSN: 0024-9297, 31 May 2003 (2003-05-31), XP002314660
WANG, ARMES: "Facile atom transfer radical polymerization of methoxy capped oligo(ethylene glycol) methacrylate in aqueous media at ambiant temperature", MACROMOLECULES, vol. 33, 2000, pages 6640 - 6647, XP002315896
HADDLETON, PERRIER, BON: "Copper (I).mediated living radical polymerization in the presence pf oxyethylene groups: online 1H NMR spectroscopy to investigate solvents effects", MACROMOLECULES, vol. 33, 10 November 2000 (2000-11-10), pages 8246 - 8251, XP002295368
WANG X-S ET AL: "FACILE SYNTHESIS OF ACIDIC COPOLYMERS VIA ATOM TRANSFER RADICAL POLYMERIZATION IN AQUEOUS MEDIA AT AMBIENT TEMPERATURE", MACROMOLECULES, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 33, no. 2, 25 January 2000 (2000-01-25), pages 255 - 257, XP000898356, ISSN: 0024-9297
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