Title:
LNA-CPG CONJUGATES
Document Type and Number:
WIPO Patent Application WO2004052909
Kind Code:
A3
Abstract:
The present invention relates to compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA -CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.
More Like This:
| WO/2013/040552 | METHODS OF PROMOTING IMMUNE TOLERANCE |
| WO/2011/008541 | MOLECULAR MARKERS AND ASSAY METHODS FOR CHARACTERIZING CELLS |
| WO/2006/054177 | IMPROVED TREATMENT OF CANCER USING TLR3 AGONISTS |
Inventors:
CATCHPOLE IAN RICHARD (GB)
Application Number:
PCT/EP2003/013803
Publication Date:
September 10, 2004
Filing Date:
December 04, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
CATCHPOLE IAN RICHARD (GB)
CATCHPOLE IAN RICHARD (GB)
International Classes:
C12N15/117; (IPC1-7): C07H21/00
Domestic Patent References:
| WO2002102825A2 | 2002-12-27 |
Other References:
See also references of EP 1567537A2
Download PDF: