Title:
LONG-ACTING SINGLE-CHAIN INSULIN ANALOG AND CONJUGATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/066570
Kind Code:
A1
Abstract:
The present invention relates to a long-acting single-chain insulin analog, a conjugate thereof and uses of both. In addition, the present invention relates to a method for preparing a long-acting single-chain insulin analog and a conjugate thereof.
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Inventors:
HEO YONG HO (KR)
OH EUH LIM (KR)
OH EUH LIM (KR)
Application Number:
PCT/KR2018/011557
Publication Date:
April 04, 2019
Filing Date:
September 28, 2018
Export Citation:
Assignee:
HANMI PHARM IND CO LTD (KR)
International Classes:
A61K47/64; A61K38/28; A61K47/54; A61K47/60; A61K47/68; C07K14/62
Domestic Patent References:
| WO2008019368A2 | 2008-02-14 | |||
| WO1997034631A1 | 1997-09-25 | |||
| WO1996032478A1 | 1996-10-17 |
Foreign References:
| KR20110134209A | 2011-12-14 | |||
| KR20160101702A | 2016-08-25 | |||
| KR20170036643A | 2017-04-03 | |||
| EP0055945A2 | 1982-07-14 | |||
| EP1926749A1 | 2008-06-04 |
Other References:
WANG, Y.: "Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production", DIABETES, vol. 3, 6 May 2014 (2014-05-06), pages 1779 - 1788, XP055510624, DOI: doi:10.2337/db13-0973
See also references of EP 3689382A4
DEREWENDA, U. ET AL., J. MOL. BIOL., vol. 220, 1991, pages 425 - 433
WILLIAM F ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, 1992, pages 419 - 425
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
H. NEURATHR.L. HILL: "The Proteins", 1979, ACADEMIC PRESS
"NCBI", Database accession no. NM_000207.2
See also references of EP 3689382A4
DEREWENDA, U. ET AL., J. MOL. BIOL., vol. 220, 1991, pages 425 - 433
WILLIAM F ET AL., THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, 1992, pages 419 - 425
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
H. NEURATHR.L. HILL: "The Proteins", 1979, ACADEMIC PRESS
"NCBI", Database accession no. NM_000207.2
Attorney, Agent or Firm:
SON, Min (KR)
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